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Development of Novel "Nonamphiphilic" Polymeric Micelles

Research Project

Project/Area Number 16510086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nanomaterials/Nanobioscience
Research InstitutionToyohashi University of Technology

Principal Investigator

YOSHIDA Eri  Toyohashi University of Technology, Department of Materials Science, Associate Professor, 工学部, 准教授 (60263175)

Co-Investigator(Kenkyū-buntansha) TAKATA Tosikazu  Tokyo Institute of Technology, Department of Organic and Polymeric Materials, Professor, 大学院・理工学研究科, 教授 (40179445)
ITSUNO Shinichi  Toyohashi University of Technology, Department of Materials Science, Professor, 工学部, 教授 (50158755)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords"Nonamphiphilic" polymers / Polymeric micelles / Spherical nanoparticles / Noncovalent bond cross-linking / Block copolymers / Random copolymers / Critical micelle concentration / Functional nanoparticles / 非両親媒性"高分子 / ミセル形成 / 超微粒子 / ナノ染料分子 / ナノ粒子化 / 紫外線吸収剤 / 高耐光性ナノ染料 / ミセル / 光散乱解析 / 水素結合 / 単量体 / 流体力学的半径 / 会合数 / 塩形成
Research Abstract

We found novel micelle formation of "nonamphiphilic" polymers consisting entirely of solvophilic segments and developed new polymeric materials using the micelle formation. We prepared nonamphiphilic block copolymers and random copolymers having electron-donating groups at the side chains. The copolymers showed no self-assembly by themselves. The light scattering studies demonstrated that the copolymers formed spherical micelles with a nanoscale in the presence of additives which have an interaction or promote salt formation with the side groups of the copolymers. The size and aggregation numbers of the micelles were dependent on the molecular weight of the polymers, the functionality and structure of the additives, indicating that the size and aggregation numbers of the micelles could be controlled by these factors. We also explored the thermodynamics and kinetics of the micellization and determined the enthalpy and entropy of the micelle formation. Furthermore, we succeeded in preparing functional nanoparticles through the micelle formation of block copolymers with functional groups. The micellization of block copolymers with dye molecules and UV absorbents produced highly light-stable nanodyes.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (55 results)

All 2007 2006 2005 2004 Other

All Journal Article (44 results) Patent(Industrial Property Rights) (11 results)

  • [Journal Article] Preparation of micelles with azo dye and UV absorbent at their cores or coronas using nonamphiphilic block copolymers2007

    • Author(s)
      Eri Yoshida, Masayo Ohta
    • Journal Title

      Colloid Polym. Sci. 285

      Pages: 431-439

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Convenient synthesis of microspheres by self-assembly of random copolymers in supercritical carbon dioxide2007

    • Author(s)
      E.Yoshida, A.Nagakubo
    • Journal Title

      Colloid Polym. Sci 285

      Pages: 441-447

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation of micelles with azo dye and UV absorbent at their cores or coronas using nonamphiphilic block copolymers2007

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Colloid Polym. Sci. 285

      Pages: 431-439

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Convenient synthesis of microspheres by self-assembly of random copolymers in supercritical carbon dioxide2007

    • Author(s)
      E.Yoshida, A.Nagakubo
    • Journal Title

      Colloid Polym. Sci. 285

      Pages: 441-447

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Micelle Formation of a Diblock Copolymer Having Pyridine as Pendant Groups by Car boxylic Acids in Nonselective Solvents2006

    • Author(s)
      Eri Yoshida, Masayo Ohta
    • Journal Title

      Colloid Polym. Sci 284

      Pages: 718-724

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oxidation-Induced Micellization of a Diblock Copolymer Containing Stable Nitroxyl Radicals2006

    • Author(s)
      Eri Yoshida, Toshikazu Tanaka
    • Journal Title

      Colloid Polym. Sci 285

      Pages: 135-144

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle Formation of a Diblock Copolymer Having Pyridine as Pendant Groups by Carboxylic Acids in Nonselective Solvents2006

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Colloid Polym. Sci. 284

      Pages: 718-724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Oxidation-Induced Micellization of a Diblock Copolymer Containing Stable Nitroxyl Radicals2006

    • Author(s)
      E.Yoshida, T.Tanaka
    • Journal Title

      Colloid Polym. Sci. 285

      Pages: 135-144

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle Formation of a Diblock Copolymer Having Pyridine as Pendant Groups by Carboxylic Acids in Nonselective Solvents2006

    • Author(s)
      Eri Yoshida, Masayo Ohta
    • Journal Title

      Colloid Polym. Sci. 284

      Pages: 718-724

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Oxidation-Induced Micellization of a Diblock Copolymer Containing Stable Nitroxyl Radicals2006

    • Author(s)
      Eri Yoshida, Toru Tanaka
    • Journal Title

      Colloid Polym. Sci. 285

      Pages: 135-144

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reversible Control of Micellization Induced by Hydrogen Bond Crosslinking for a Nonamphiphilic Diblock Copolymer with an α, ω-Diamine2005

    • Author(s)
      Eri Yoshida, Masayo Ohta, Yoshikazu Terada
    • Journal Title

      Polym. Adv. Technol 16

      Pages: 183-188

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thermodynamics and kinetics on micelle formation of a nonamphiphilic poly(vinylphenol)-block-polystyrene by α, ω-Dia mine2005

    • Author(s)
      Eri Yoshida, Shinichi Itsuno
    • Journal Title

      Colloid Polym. Sci 284

      Pages: 19-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle formation of a nonamphiphilic poly (vinylphenol)-block-polystyrene diblock cop olymer in ethyl acetate2005

    • Author(s)
      Eri Yoshida, Yoshikazu Terada
    • Journal Title

      Colloid Polym. Sci 283

      Pages: 1190-1196

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation of Micelles with Azobenzene at Their Coronas or Cores from 'Nona mphiphilic' Diblock Cop Copolymers2005

    • Author(s)
      Eri Yoshida, Masayo Ohta
    • Journal Title

      Colloid Polym. Sci 283

      Pages: 521-531

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation of light-stable micelles with azo dyes from a nonamphiphilic random block copolymer2005

    • Author(s)
      Eri Yoshida, Masayo Ohta
    • Journal Title

      Colloid Polym. Sci 283

      Pages: 872-879

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation of micelles having a UV absorbent at their coronas using a 'nonamphiphilic diblock copolymer2005

    • Author(s)
      Eri Yoshida, Masayo Ohta
    • Journal Title

      Designed Monomers and Polymer 8

      Pages: 501-513

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Direct preparation of core cross-linked micelles in a nonselective solvent2005

    • Author(s)
      Eri Yoshida, Motonari Tanaka, Toshikazu Takata
    • Journal Title

      Colloid Polym. Sci 284

      Pages: 51-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Self-assembly control of a pyridine-containing diblock copolymer by perfluorinated counter anions during salt-induced micellization2005

    • Author(s)
      Eri Yoshida, Motonari Tanaka, Toshikazu Takata
    • Journal Title

      Colloid Polym. Sci 283

      Pages: 1100-1107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Reversible Control of Micellization Induced by Hydrogen Bond Crosslinking for a Nonamphiphilic Diblock Copolymer with an a,ω-Diamine2005

    • Author(s)
      E.Yoshida, M.Ohta, Y.Terada
    • Journal Title

      Polym. Adv. Technol. 16

      Pages: 183-188

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thermodynamics and kinetics on micelle formation of a nonamphiphilic poly(vinylphenol)-block-polystyrene by a, w- Diamine2005

    • Author(s)
      E.Yoshida, S.Itsuno
    • Journal Title

      Colloid Polym. Sci. 284

      Pages: 19-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle formation of a nonamphiphilic poly(vinylphenol)-block-polystyrene diblock copolymer in ethyl acetate2005

    • Author(s)
      E.Yoshida, Y.Terada
    • Journal Title

      Colloid Polym. Sci. 283

      Pages: 1190-1196

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation of Micelles with Azobenzene at Their Coronas or Cores from 'Nonamphiphilic' Diblock Copolymers2005

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Colloid Polym. Sci. 283

      Pages: 521-531

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation of light-stable micelles with azo dyes from a nonamphiphilic random block copolymer2005

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Colloid Polym. Sci. 283

      Pages: 872-879

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preparation of micelles having a UV absorbent at their coronas using a 'nonamphiphilic' diblock copolymer2005

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Designed Monomers and Polymers 8(5)

      Pages: 501-513

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Direct preparation of core cross-linked micelles in a nonselective solvent2005

    • Author(s)
      E.Yoshida, M.Tanaka, T.Takata
    • Journal Title

      Colloid Polym. Sci. 284

      Pages: 51-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Self-assembly control of a pyridine-containing diblock copolymer by perfluorinated counter anions during salt-induced micellization2005

    • Author(s)
      E.Yoshida, M.Tanaka, T.Takata
    • Journal Title

      Colloid Polym. Sci. 283

      Pages: 1100-1107

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Direct preparation of core cross-linked micelles in a nonselective solvent2005

    • Author(s)
      E.Yoshida, M.Tanaka, T.Takata
    • Journal Title

      Colloid Polym.Sci. 284

      Pages: 51-57

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Thermodynamics and kinetics on micelle formation of a nonamphiphilic poly(vinylphenol)-block-polystyrene by α,ω-Diamine2005

    • Author(s)
      E.Yoshida, S.Istuno
    • Journal Title

      Colloid Polym.Sci. 284

      Pages: 19-25

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Micelle formation of a nonamphiphilic poly(vinylphenol)-block-polystyrene diblock copolymer in ethyl acetate2005

    • Author(s)
      E.Yoshida, Y.Terada
    • Journal Title

      Colloid Polym.Sci. 283

      Pages: 1190-1196

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Self-assembly control of a pyridine-containing diblock copolymer by perfluorinated counter anions during salt-induced micellization2005

    • Author(s)
      E.Yoshida, M.Tanaka, T.Takata
    • Journal Title

      Colloid Polym.Sci. 283

      Pages: 1100-1107

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Preparation of light-stable micelles with azo dyes from a nonamphiphilic random block copolymer2005

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Colloid Polym.Sci. 283

      Pages: 872-879

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Reversible Control of Micellization Induced by Hydrogen Bond Crosslinking for a Nonamphiphilic Diblock Copolymer with an α,ω-Diamine2005

    • Author(s)
      E.Yoshida, M.Ohta, Y.Terada
    • Journal Title

      Polym.Adv.Technol. 16

      Pages: 183-188

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Preparation of Micelles with Azobenzene at Their Coronas or Cores from ‘Nonamphiphilic' Diblock Copolymers2005

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Colloid Polymer Science 283

      Pages: 521-521

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Micelle Formation of 'Nonamphiphilic' Poly (vinylphenol-co-styrene) Random Copolymers by Hydrogen B ond Cross-linking by α,ω-Diamine2004

    • Author(s)
      Eri Yoshida, Akiko Hironaka
    • Journal Title

      Polym. J. 36

      Pages: 248-254

    • NAID

      10012681403

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle Formation of 'Nonamphiphilic' Poly(vinylphenol-co-styrene) Random Copolymers by Hydrogen Bond Cross- linking by a,ω-Diamine2004

    • Author(s)
      E.Yoshida, A.Hironaka
    • Journal Title

      Polym. J. 36

      Pages: 248-254

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle Formation of ‘Nonamphiphilic' Poly(vinylphenol-co-styrene) Random Copolymers by Hydrogen Bond Cross-linking by α,ω-Diamine2004

    • Author(s)
      E.Yoshida, A.Hironaka
    • Journal Title

      Polymer Journal 36

      Pages: 248-248

    • NAID

      10012681403

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Control of Self-Assembly by Perfluorinated Counter Anions in Salt-Induced Micellization of a Pyridine-Containing Diblock Copolymer2004

    • Author(s)
      E.Yoshida, M.Tanaka, T.Takata
    • Journal Title

      Am.Chem.Soc., Polymer Preprint 45(1)

      Pages: 832-832

    • Related Report
      2004 Annual Research Report
  • [Journal Article] TEM observation of nonamphiphilic copolymer micelles

    • Author(s)
      Eri Yoshida
    • Journal Title

      Colloid Polym. Sci (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle Formation Induced by Disproportionation of Stable Nitroxyl Radicals Supported on a Diblock Copolymer

    • Author(s)
      Eri Yoshida, Hiromitsu Ogawa
    • Journal Title

      J Oleo Sci (印刷中)

    • NAID

      130000055476

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] TEM observation of nonamphiphilic copolymer micelles

    • Author(s)
      E.Yoshida
    • Journal Title

      Colloid Polym. ScL (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Micelle Formation Induced by Disproportionation of Stable Nitroxyl Radicals Supported on a Diblock Copolymer

    • Author(s)
      E.Yoshida, H.Ogawa
    • Journal Title

      J. Oleo ScL (in press)

    • NAID

      130000055476

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Reversible Control of Miceillization Induced by Hydrogen Bond Cross-Linking for a Nonamphiphilic Diblock Copolymer with an α,ω-Diamine

    • Author(s)
      E.Yoshida, M.Ohta, Y.Terada
    • Journal Title

      Polym.Adv.Technol. 印刷中

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Preparation of light-stable micelles with azo dyes from a nonamphiphilic random block copolymer

    • Author(s)
      E.Yoshida, M.Ohta
    • Journal Title

      Colloid Polymer Science 印刷中

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Self-assembly control of a pyridine-containing diblock copolymer by perfluorinated counter anions during salt-induced micellization

    • Author(s)
      E.Yoshida, M.Tanaka, T.Takata
    • Journal Title

      Colloid Polymer Science 印刷中

    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] 高分子集合体からなる共重合体、その微粒子及びその微粒子の製造方法2007

    • Inventor(s)
      吉田絵里, 長久保商人
    • Industrial Property Rights Holder
      吉田絵里, 長久保商人
    • Filing Date
      2007-03-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 超臨界ないしは亜臨界流体中で機能する高分子界面活性剤およびその製造方法2006

    • Inventor(s)
      吉田絵里, 今村ひろ子
    • Industrial Property Rights Holder
      吉田絵里, 今村ひろ子
    • Industrial Property Number
      2006-242889
    • Filing Date
      2006-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 不均化反応を利用した高分子超微粒子の製造方法2006

    • Inventor(s)
      吉田絵里, 小川裕充
    • Industrial Property Rights Holder
      吉田絵里, 小川裕充
    • Industrial Property Number
      2006-242986
    • Filing Date
      2006-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 高分子集合体からなる球状微粒子及びその微粒子の製造方法2006

    • Inventor(s)
      吉田絵里, 峰山亜希子
    • Industrial Property Rights Holder
      吉田絵里, 峰山亜希子
    • Industrial Property Number
      2006-242547
    • Filing Date
      2006-09-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 自己凝集力を利用する球状の高分子微粒子の製造方法2006

    • Inventor(s)
      吉田絵里, 峰山亜希子
    • Industrial Property Rights Holder
      吉田絵里, 峰山亜希子
    • Filing Date
      2006-12-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 高分子集合体からなる共重合体、その微粒子及びその微粒子の製造方法2006

    • Inventor(s)
      吉田絵里, 長久保商人
    • Industrial Property Rights Holder
      豊橋技術科学大学
    • Filing Date
      2006-09-08
    • Related Report
      2006 Annual Research Report
  • [Patent(Industrial Property Rights)] 機能性高分子超微粒子とそれを用いるカルボニル化合物の製造方法2005

    • Inventor(s)
      吉田絵里, 田中徹
    • Industrial Property Rights Holder
      吉田絵里, 田中徹
    • Industrial Property Number
      2005-354242
    • Filing Date
      2005-12-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 自己組織化により生成する機能性高分子超微粒子とその製法2005

    • Inventor(s)
      吉田絵里, 田中徹
    • Industrial Property Rights Holder
      吉田絵里, 田中徹
    • Industrial Property Number
      2005-275837
    • Filing Date
      2005-09-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 高分子集合体からなる球状超微粒子およびその製造2005

    • Inventor(s)
      吉田 絵里, 長久保 商人
    • Industrial Property Rights Holder
      豊橋技術科学大学
    • Industrial Property Number
      2005-274599
    • Filing Date
      2005-09-21
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 自己組織化により生成する機能性高分子超微粒子とその製法2005

    • Inventor(s)
      吉田 絵里, 田中 徹
    • Industrial Property Rights Holder
      豊橋技術科学大学
    • Industrial Property Number
      2005-275837
    • Filing Date
      2005-09-22
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 機能性高分子超微粒子とそれを用いるカルボニル化合物の製造方法2005

    • Inventor(s)
      吉田 絵里, 田中 徹
    • Industrial Property Rights Holder
      豊橋技術科学大学
    • Industrial Property Number
      2005-354242
    • Filing Date
      2005-12-07
    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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