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Hippocampal-amygdalar-prefrontal circuits in the relationship between memory and emotion

Research Project

Project/Area Number 16530484
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental psychology
Research InstitutionNational Institute of Advanced Industrial Science and Technology (AIST)

Principal Investigator

TAKITA Masatoshi  National Institute of Advanced Industrial Science and Technology (AIST), Research Institute for Human Science and Biomedical Engineering, Senior Research Scientist, 人間福祉医工学研究部門, 主任研究員 (40344204)

Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsLearning / Memory / Emotion / Hippocampus / Amygdala / Prefrontal cortex / Neuroplasticity / 桃体 / 作業記憶 / 恐怖条件づけ / イボテン酸 / 寡動
Research Abstract

The hippocampal-medial prefrontal cortex (mPFC) pathway provides highly convergent input to the mPFC in rats and shows two types of short-term plasticity in terms of paired-pulse facilitation (PPF) of the field potential under urethane anesthesia. We now report that stimulating either the dorsal or ventral subregions of the posterior hippocampus elicited PPF (by about 335 and 120 %, respectively) of field potentials recorded in the mPFC at 100 ms interpulse interval. This PPF-like interaction occurred when projections were stimulated in the ventral-dorsal order (by about 200% of the single-pulsed response), but not vice versa. When weak long-term potentiation (LTP) of the dorsal projection was evoked simultaneously with strong LTP of the ventral projection, an associative effect was revealed (about +55 %), although the magnitudes of LTP in each projection were not correlated. Even when the impermutable PPF-like facilitation was further enhanced (by about +120 %), the enhancement was no … More t correlated with either form of LTP, but exhibited the interaction of changes in the dorsal PPF, rather than in the heterotopic priming effect through the ventral projection. Moreover, this change was correlated with the associated LTP ratio of dorsal to ventral projection LTP (i.e., LTP associativity). Larger increases in LTP associativity correlated with greater impermutable PPF-like facilitation; in addition, there was hardly attenuation of the response to the dorsal projection by subsequent electrolytic lesions of the ventral subregion. // After conditioning rats to a 1-min auditory tone paired with pulsed footshock, an intensity of 1.0 mA caused more consolidated and inextinguishable freezing in response to both context and tone on consecutive test days 7-8 when the co-monitored activities were lower, than those on days 1-2 of another version (incubation effect). The two indexes showed a mutual negative correlation at 0.5 but not at 1.0 mA regardless of test retention days (resource-loss of activity). Ibotenate lesions of the bilateral amygdala on the post-conditioning day reduced freezing and restored the hypoactivity evident on days 7-8 (0-35 and 150-300 % of sham, respectively) to a greater extent than lesions of the hippocampus, unlike lesions of the medial prefrontal cortex. Unexpectedly, three disconnection versions to intrahemispheric interactions among these, one unilateral and another contralateral lesions out of three regions, reproduced freezing reduction consistent with bilateral amygdala lesions, whereas consistent restoration of hypoactivity appeared in the amygdala-hippocampal rather than the amygdala-or hippocampal-prefrontal version. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (36 results)

All 2007 2006 2005 2004

All Journal Article (36 results)

  • [Journal Article] In vivo temporal property of GABAergic neural transmission in collateral feed-forward inhibition system of hippocampal-prefrontal pathway2007

    • Author(s)
      Masatoshi Takita
    • Journal Title

      Brain Research 1150

      Pages: 69-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Causality between brain chemical element and behavioral response concerning learning, memory, and emotion in an open field test.2007

    • Author(s)
      Takita M
    • Journal Title

      Journal of Physiological Sciences 57・S

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vivo temporal property of GABAergic neural transmission in collateral feed-forward inhibition system of hippocampal-prefrontal pathway.2007

    • Author(s)
      Takita M, Kuramochi M, Izaki Y, Ohtomi M.
    • Journal Title

      Brain Research 1150

      Pages: 69-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Causality between brain chemical element and behavioral response concerning learning, memory, and emotion in an open field test.2007

    • Author(s)
      Takita M, Inagaki K.
    • Journal Title

      Journal of Physiological Sciences 57-S

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] n vivo temporal property of GABAergic neural transmission in collateral feed-forward inhibition system of hippocampal-prefrontal pathway2007

    • Author(s)
      Masatoshi Takita, Masahito Kuramochi, Yoshinori Izaki, Michiko Ohtomi
    • Journal Title

      BRAIN RESEARCH (http://dx.doi.org/10.1016/j.brainres.2007.02.063) (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cooperativity between hippocampal-prefrontal short-term plasticity through associative long-term potentiation2006

    • Author(s)
      Hitoshi Kawashima
    • Journal Title

      Brain Research 1109

      Pages: 37-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cooperativity between heterosynaptic short-term interaction and associative long-term potentiation in the dorsal and ventral hippocampal-prefrontal pathways.2006

    • Author(s)
      Takita M
    • Journal Title

      FAOPS 2006 abstract

      Pages: 278-278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of locomotor activity influenced by learning, memory, and emotion : Involvement of dopamine transmission in the prefrontal cortex.2006

    • Author(s)
      Takita M
    • Journal Title

      Journal of Physiological Sciences 56・S

    • NAID

      130005448507

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 細胞外分子モニクリング : ラット前頭前野ドーパミン動態と学習・記憶・情動2006

    • Author(s)
      岡田夏美
    • Journal Title

      化学工学会つくば化学技術懇話会要旨集

      Pages: 33-33

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cooperativity between hippocampal-prefrontal short-term plasticity through associative long-term potentiation.2006

    • Author(s)
      Kawashima H, Izaki Y, Grace AA, Takita M.
    • Journal Title

      Brain Research 1109

      Pages: 37-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cooperativity between heterosynaptic short-term interaction and associative long-term potentiation in the dorsal and ventral hippocampal-prefrontal pathways.2006

    • Author(s)
      Takita M.
    • Journal Title

      FAOPS 2006 abstract

      Pages: 278-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of locomotor activity influenced by learning, memory, and emotion : Involvement of dopamine transmission in the prefrontal cortex.2006

    • Author(s)
      Takita M.
    • Journal Title

      Journal of Physiological Sciences 56-S

    • NAID

      130005448507

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cooperativity between hippocampal-prefrontal short-term plasticity through associative long-term potentiation2006

    • Author(s)
      Hitoshi Kawashima, Yoshinori Izaki, Anthony A. Grace, Masatoshi Takita
    • Journal Title

      BRAIN RESEARCH 1109

      Pages: 37-44

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neuroplastic cooperativity between the thalamo-prefrontal and hippocampo-prefrontal pathways in rats2006

    • Author(s)
      Masatoshi Takita, Michiko Ohtomi
    • Journal Title

      NEUROSCIENCE RESEARCH 55

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cooperativity between heterosynaptic short-term interaction and associative long-term potentiation in the dorsal and ventral hippocampal-prefrontal pathways2006

    • Author(s)
      Masatoshi Takita
    • Journal Title

      FAOPS 2006 abstract

      Pages: 278-278

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Causality between brain chemical element and open-field behaviors concerning learning, memory, and emotion2006

    • Author(s)
      Masatoshi Takita, Kazumi Inagaki
    • Journal Title

      JOURNAL OF PHYSIOLOGICAL SCIENCES 57

    • NAID

      130005449114

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Analysis of locomotor activity influenced by learning, memory, and emotion : Involvement of dopamine transmission in the prefrontal cortex2006

    • Author(s)
      瀧田 正寿
    • Journal Title

      Journal of Physiological Sciences 56巻・S号

    • NAID

      130005448507

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neuroplastic cooperativity between the thalamo-prefrontal and hippocampo- prefrontal pathways in rats2005

    • Author(s)
      Watanabe Y
    • Journal Title

      Society for Neuroscience Abstract 2005

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] マイクロダイアリシスを用いた前頭前野シナプス可塑性の研究2005

    • Author(s)
      瀧田 正寿
    • Journal Title

      第10回 神経科学領域における分子モニタリングシンポジウムproceedings

      Pages: 6-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparison of neuroplastic cooperativity to the thalamo-prefrontal pathway between the posterior dorsal and the ventral hippocampal afferents2005

    • Author(s)
      Watanabe Y
    • Journal Title

      Neuroscience Research 52・S

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of locomotor activity influenced by learning, memory, and emotion : a comparison of lesions among prefrontal cortex, hippocampus, and amygdala, and their functional connections2005

    • Author(s)
      Takita M
    • Journal Title

      Japanese Journal of Physiology 55・S

    • NAID

      130005447685

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Interaction of synaptic plasticity in the prefrontal cortex between the thalamic and hippocampal efferents in rats2005

    • Author(s)
      Watanabe Y
    • Journal Title

      Japanese Journal of Physiology 55・S

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Comparison of neuroplastic cooperativity to the thalamo-prefrontal pathway between the posterior dorsal and the ventral hippocampal afferents.2005

    • Author(s)
      Watanabe Y, Takita M.
    • Journal Title

      Neuroscience Research 52-S

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of locomotor activity influenced by learning, memory, and emotion : a comparison of lesions among prefrontal cortex, hippocampus, and amygdala, and their functional connections2005

    • Author(s)
      Takita M.
    • Journal Title

      Japanese Journal of Physiology 55-S

      Pages: 5182-5182

    • NAID

      130005447685

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Interaction of synaptic plasticity in the prefrontal cortex between the thalamic and hippocampal efferents in rats2005

    • Author(s)
      Watanabe Y, Takita M.
    • Journal Title

      Japanese Journal of Physiology 55-S

    • NAID

      130007039101

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Analysis of locomotor activity influenced by learning, memory, and emotion : a comparison of lesions among prefrontal cortex, hippocampus, and amygdala, and their functional connections2005

    • Author(s)
      瀧田 正寿
    • Journal Title

      JAPANESE JOURNAL OF PHYSIOLOGY 55巻・S号

    • NAID

      130005447685

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Interaction of synaptic plasticity in the prefrontal cortex between the thalamic and hippocampal efferents in rats2005

    • Author(s)
      渡辺 由美子
    • Journal Title

      JAPANESE JOURNAL OF PHYSIOLOGY 55巻・S号

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparison of neuroplastic cooperativity to the thalamo-prefrontal pathway between the posterior dorsal and the ventral hippocampal afferents2005

    • Author(s)
      渡辺 由美子
    • Journal Title

      NEUROSCIENCE RESEARCH 52巻・S号

    • Related Report
      2005 Annual Research Report
  • [Journal Article] NEUROPLASTIC COOPERATIVITY BETWEEN THE THALAMO-PREFRONTAL AND HIPPOCAMPO-PREFRONTAL PATHWAYS IN RATS2005

    • Author(s)
      渡辺 由美子
    • Journal Title

      Society for Neuroscience Abstract 2005

    • Related Report
      2005 Annual Research Report
  • [Journal Article] マイクロダイアリシスを用いた前頭前野シナプス可塑性の研究2005

    • Author(s)
      瀧田 正寿
    • Journal Title

      第10回神経科学領域における分子モニタリングシンポジウムproceedings

      Pages: 6-7

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Extracellular level of basolateral amygdalar dopamine responding to reversal of appetitive-conditioned discrimination in young and old rats2004

    • Author(s)
      Masahiko Nomura
    • Journal Title

      Brain Research 1018(2)

      Pages: 241-246

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Difference in dynamical property to paired-pulse facilitation of two LTP-inducible hippocampal-prefrontal cortex pathways of rats2004

    • Author(s)
      Kuramochi M
    • Journal Title

      Neuroscience Research 50・S

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Extracellular level of basolateral amygdalar dopamine responding to reversal of appetitive-conditioned discrimination in young and old rats.2004

    • Author(s)
      Nomura M, Izaki Y, Takita M, Tanaka J, Hori K.
    • Journal Title

      Brain Research 1018

      Pages: 241-246

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Difference in dynamical property to paired-pulse facilitation of two LTP-inducible hippocampal-prefrontal cortex pathways of rats2004

    • Author(s)
      Kuramochi M, Izaki Y, Ohtomi M, Takita M.
    • Journal Title

      Neuroscience Research 50-S

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of ventral hippocampal long-term potentiation and depression on the gamma-band local field potential in anesthetized rats.2004

    • Author(s)
      Izaki Y, Takita M, Nomura M, Akema T.
    • Journal Title

      Exp Brain Research 157(2)

      Pages: 147-151

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Extracellular level of basolateral amygdalar dopamine responding to reversal of appetitive-conditioned discrimination in young and o2004

    • Author(s)
      Nomura M, Izaki Y, Takita M, Tanaka I, Hori K.
    • Journal Title

      Brain Research 1018(2)

      Pages: 241-246

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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