| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Research Abstract |
The unique electronic, chemical and mechanical properties of carbon nanotubes (CNTs) make them extremely attractive for chemical and biochemical sensors. Preliminary studies demonstrated that CNTs have fast electron-transfer kinetics and concentration function suggesting that they may serve as excellent transducers for biosensors.
Low molecular weight enzymes such as horseradish peroxidase (HRP) and microperoxidase (MP-11) were physically adsorbed onto the nanotube electrode. As a result, HRP-based nanotube biosensor responded to hydrogen peroxide with high sensitivity, while MP-11-based nanotube biosensor was very stable for its repeated use. Also, glucose sensor prepared by covalent bonding of glucose oxidase into the nanotube responded sensitively to glucose in the presence of benzoquinone as an electrochemical mediator. Furthermore, nanotube electrodes modified with crown, cyclodextrine, and cyclic polyamine responded sensitively to catecholamine, bisphenol A, dicarbonic acid compounds, respectively, with some concentration functions based on the host-gest interactions.
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