| Project/Area Number |
16550125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional materials chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
TAKAGI Yumiko Kagawa University, Faculty of Education, Assistant Professor, 教育学部, 助教授 (50263413)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIHARA Hiroshi Kagawa University, Faculty of Education, Professor, 教育学部, 教授 (80036029)
ITOH Toshiyuki Tottori University, Faculty of Engineering, Professor, 工学部, 教授 (50193503)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Ferroelectric liquid crystal compounds / Anti-ferroelectric liquid crystal compounds / Lipase / Fluoro Alkanol / Optically Pure |
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| Research Abstract |
Ant ferroelectric liquid crystal compounds(AFCLs), which possess a chiral 1,1,1-trifluoromethyl-2-alkanol moiety, are known to be important high-speed switching devices. Kusumoto and his colleagues recently the synthesis of unique dimeric AFLCs molecules which contain optically active bis(trifluoromethyl)alkanediols as chiral core units. The reported means for preparing optically pure bis(trifluoromethyl)alkanediols, however, required a nuisance resolution process using HPLC on chiral phase. We previously reported that Candida antarctica lipase catalyzed trans-esterification of racemic 1,1,1-trifluoro-2-alkanols with perfect enantioselectivity. We also achieved the hydrolysis of acetate more effectively. We next attempted trans-sterification of diol 1 in organic solvent using vinyl acetate as an acyl donor. Trans-esterification, however, did not take place. Fortunately, hydrolysis reaction of (±)-1 proceeded smoothly to provide monoacetate and diol with efficient enantioselectivity. We report the results of lipase-catalyzed hydrolysis reaction of bis(trifluoromethyl)alkanediols. Using optically active bis(trifluormethyl)-alkanediols obtained in this reaction as starting materials, synthesis of novel dimer type AFCLs has been demonstrated.
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