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Study of the signaling network via mutifundtional receptor, RAGE.

Research Project

Project/Area Number 16570113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionKANAZAWA UNIVERSITY

Principal Investigator

WATANABE Takuo  Kanazawa University, Graduate School of Medical Science, Associate Professor, 医学系研究科, 助教授 (40303268)

Co-Investigator(Kenkyū-buntansha) YONEKURA Hideto  Kanazawa University, Graduate School of Medical Science, Associate Professor, 医学系研究科, 助教授 (80240373)
YAMAMOTO Yasuhiko  Kanazawa University, Graduate School of Medical Science, Instructor, 医学系研究科, 助手 (20313637)
YAMAMOTO Hiroshi  Kanazawa University, Graduate School of Medical Science, Professor, 医学系研究科, 教授 (00115198)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsRAGE / AGE / signaling / tyrosine phosphorylation / co-receptor / FRET
Research Abstract

RAGE (receptor for advanced glycation endproducts) is a cell surface receptor that bind several ligands, such as AGE (advanced glycation endproducts), HMGB-1 (high molecular group box-1 protein), amyloid beta. The intracellular signals evoked by RAGE-ligand interaction were thought to play pivotal roles in development of various diseases. However, the mechanism of generation of intracellular signals by RAGE was poorly understood.
In this research we revealed the presence of novel signaling pathway that is activated by the association of RAGE (receptor for advanced glycation endproducts) with its ligands. The pathway appears to involve tyrosine phosphorylation. We also found tyrosine-phosphorylated proteins that associate with RAGE on cell surface.
(1) We found increased tyrosine-phosphorylation of several proteins after ligand stimulation. Their phosphorylation requires cytoplasmic domain of RAGE because the increase of tyrosine-phosphorylation was not observed in a cell line that expres … More s cytoplasmic domain-deleted RAGE. We identified several candidates of those proteins by mass-spectrometry.
(2) We revealed that the stimulation-dependent tyrosine phosphorylation event was located upstream of ERK activation or on ERK-independent signaling pathway, using kinase inhibitors. Furthermore, tyrosine phosphorylation of a few proteins was regulated by tyrosine phosphatase.
(3) We found that several tyrosine-phosphorylated proteins associated with RAGE on cell surface using cross-linking followed by immunoprecipitation.
(4) We found that the tyrosine phosphorylation of the RAGE associated proteins was enhanced by ligand stimulation in dose-dependent and time-dependent manner. These proteins might be co-receptors of RAGE.
(5) We identified a known whose tyrosine-phosphorylation was enhanced by RAGE ligands using antibody array that evaluate tyrosine phosphorylation of known receptor tyrosine. A few known receptor tyrosine kinases were constitutively activated by full-length RAGE or cytoplasmic domain-deleted RAGE. These receptors might be involved in RAGE dependent-signaling pathways Less

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (73 results)

All 2006 2005 2004 Other

All Journal Article (46 results) Book (17 results) Patent(Industrial Property Rights) (10 results)

  • [Journal Article] A severe diabetic nephropathy model with early development of nodule-like lesions induced by megsin overexpression in the RAGE/iNOS transgenic mice.2006

    • Author(s)
      Inagi, R. et al.
    • Journal Title

      Diabetes 55(2)

      Pages: 356-366

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Isoflavones Inhibit Nicotine C-Oxidation Catalyzed by Human CYP2A6.2006

    • Author(s)
      Nakajima, M., et al.
    • Journal Title

      J.Clin.Pharmacol. 46(3)

      Pages: 337-344

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Isolation and expression analysis of mouse endogenous secretory receptor for advanced glycation endproducts (esRAGE).2006

    • Author(s)
      Harashima, A., et al.
    • Journal Title

      Biochem.J. 396(1)

      Pages: 109-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of an ELISA system for a circulating decoy receptor for AGE and its application to type I diabetic patients.2006

    • Author(s)
      Sakurai, S., et al.
    • Journal Title

      Diabetes Res.Clin.Pract. in press 2006 Feb 17;[Epub ahead of print]

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Development of an ELISA system for a circulating decoy receptor for AGE and its application to type I diabetic patients.2006

    • Author(s)
      Sakurai, S., et al.
    • Journal Title

      Diabetes Res.Clin.Pract. (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Isolation and expression analysis of mouse endogenous secretory receptor for advanced glycation endproducts(esRAGE).2006

    • Author(s)
      Harashima, A., et al.
    • Journal Title

      Biochem.J. (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high mobility group-B1.2005

    • Author(s)
      Abeyama, K. et al.
    • Journal Title

      J.Clin.Invest. 115(5)

      Pages: 1267-1274

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs.2005

    • Author(s)
      Cheng, C. et al.
    • Journal Title

      Mod.Pathol. 18(10)

      Pages: 1385-1396

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasma level of endogenous secretory receptor for advanced glycation endproducts (esRAGE) is associated with components of the metabolic syndrome and atherosclerotic arterial wall thickness.2005

    • Author(s)
      Koyama, H., et al.
    • Journal Title

      Arterioscler.Thromb.Vasc.Biol. 25(12)

      Pages: 2587-2593

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury.2005

    • Author(s)
      Yonekura, H. et al.
    • Journal Title

      J.Pharmacol.Sci. 97(3)

      Pages: 305-311

    • NAID

      10025726330

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Blockage of diabetic vascular injury by controlling of AGE-RAGE system.2005

    • Author(s)
      Mynt, K.M.et al.
    • Journal Title

      Current Drug Targets 6(4)

      Pages: 447-452

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Receptor for advanced glycation end products is a promising target of diabetic nephropathy.2005

    • Author(s)
      Yamamoto, Y., et al.
    • Journal Title

      Ann.N.Y.Acad.Sci. 1043

      Pages: 562-566

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Atherosclerosis and restenosis : is there a role for RAGE?2005

    • Author(s)
      Nawroth P., et al.
    • Journal Title

      Curr.Diab.Rep. 5(1)

      Pages: 11-16

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] AGE-RAGE系2005

    • Author(s)
      原島 愛, 他
    • Journal Title

      日本臨床 63(Suppl.6)

      Pages: 62-66

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 糖尿病腎症におけるAGE-RAGE相互作用2005

    • Author(s)
      山本 靖彦, 他
    • Journal Title

      内分泌・糖尿病科 20(3)

      Pages: 243-250

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 糖尿病血管の合併症について2005

    • Author(s)
      山本 博
    • Journal Title

      食品加工技術 24(4)

      Pages: 208-210

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 糖尿病血管合併症の分子機構-糖化蛋白受容体(RAGE)の役割-2005

    • Author(s)
      米倉 秀人
    • Journal Title

      金沢大学十全医学会雑誌 114(4)

      Pages: 137-141

    • NAID

      110004746925

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] グリケーションと血管内皮障害2005

    • Author(s)
      三浦 順之助, 他
    • Journal Title

      糖尿病 48(12)

      Pages: 821-823

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high mobility group-B1.2005

    • Author(s)
      Abeyama, K. et al.
    • Journal Title

      J.Clin.Invest 115(5)

      Pages: 1267-1274

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Roles of the receptor for advanced glycation endproducts in diabetes-iduced vascular injury.2005

    • Author(s)
      Yonekura, H., et al.
    • Journal Title

      J.Pharmacol.Sci. 97(3)

      Pages: 305-311

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs.2005

    • Author(s)
      Cheng, C., et al.
    • Journal Title

      Mod.Pathol. 18(10)

      Pages: 1385-1396

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Blockage of diabetic vascular injury by controlling of AGE-RAGE system.2005

    • Author(s)
      Mynt K.M., et al.
    • Journal Title

      Current Drug Targets 6(4)

      Pages: 447-452

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 糖尿病血管合併症の分子機構_糖化蛋白受容体(RAGE)の役割_2005

    • Author(s)
      米倉秀人
    • Journal Title

      金沢大学十全医学会雑誌 114巻(4号)

      Pages: 137-141

    • NAID

      110004746925

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 糖尿病腎症におけるAGE-RAGE相互作用2005

    • Author(s)
      山本靖彦, 他
    • Journal Title

      内分泌・糖尿病科 20(3)

      Pages: 243-250

    • Related Report
      2005 Annual Research Report
  • [Journal Article] グリケーションと血管内皮障害2005

    • Author(s)
      三浦順之助, 他
    • Journal Title

      糖尿病 48(12)

      Pages: 821-823

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Blockade of diabetic vascular injury by controlling of AGE-RAGEsystem2005

    • Author(s)
      Myint, K.M.
    • Journal Title

      Current Drug Targets (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Roles of the receptor for advanced glycation endoproducts in diabtese-induced vascular injury2005

    • Author(s)
      Yonekura, H.
    • Journal Title

      J.Pharmcol.Sci. (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] RAGE is a promising target of diabetic nephropathy.2005

    • Author(s)
      Yamamoto, Y.
    • Journal Title

      Ann.N.Y.Acad.Sci. (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression profiling of endogenous secretory receptor for advanced glycation endproducts in human organs : comparative study with domain-specific antibodies.2005

    • Author(s)
      Cheng, C.
    • Journal Title

      Modern Pathology (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 糖尿病甚症におけるAGE-RAGE相互作用2005

    • Author(s)
      山本 靖彦
    • Journal Title

      内分泌 (In press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Advanced glycation endproducts increase collagen-specific chaperone protein in mouse diabetic nephropathy.2004

    • Author(s)
      Ohashi, S., et al.
    • Journal Title

      J.Biol.Chem. 279(19)

      Pages: 19816-19823

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Possible participation of pICln in the regulation of angiogenesis through alternative splicing of VEGF receptor mRNAs.2004

    • Author(s)
      Li, H.et al.
    • Journal Title

      Endothelium 11(5-6)

      Pages: 293-300

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes2004

    • Author(s)
      Miura, J. et al.
    • Journal Title

      J.Diabetes Complications 18(1)

      Pages: 53-59

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture2004

    • Author(s)
      Kaji, T. et al.
    • Journal Title

      Biol.Pharm.Bull. 27(11)

      Pages: 1763-1768

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 糖化蛋白による血管障害とその防止の分子機構2004

    • Author(s)
      武内 章彦, 他
    • Journal Title

      血管 27(4)

      Pages: 125-130

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 21世紀のアンチセンス学2004

    • Author(s)
      山本 博
    • Journal Title

      Antisense(アンチセンスDNA/RNA研究会) 8(1)

      Pages: 2-3

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes.2004

    • Author(s)
      Miura, J. et al.
    • Journal Title

      J.Diabetes Complications 18(1)

      Pages: 53-59

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture.2004

    • Author(s)
      Kaji, T. et al.
    • Journal Title

      Biol.Pharm.Bull. 27(11)

      Pages: 1763-1768

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nurture vs.nature in diabetic vasculopathy : roles of advanced glycation endproducts and the receptor for them.2004

    • Author(s)
      Yamamoto, Y. et al.
    • Journal Title

      International Congress Series 1262 (Atherosclerosis XIII) (ELSEVIER SCIENCE, Amsterdam, Amsterdam)

      Pages: 164-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hyporeninemic hypoaldosteronism.2004

    • Author(s)
      Hatakeyama, H. et al.
    • Journal Title

      Encyclopedia of Endocrine Diseases (ELSEVIER SCIENCE, Amsterdam) Volume 2

      Pages: 672-674

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Advanced glycation endproducts increase collagen-specific chaperone protein in mouse diabetic nephropathy.2004

    • Author(s)
      Ohashi, S.
    • Journal Title

      J.Biol.Chem. 279(19)

      Pages: 19816-19823

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Possible participation of pICln in the regulation of angiogenesis through alternative splicing of VEGF receptor mRNAs.2004

    • Author(s)
      Li, H.
    • Journal Title

      Endothelium 11(5-6)

      Pages: 293-300

    • Related Report
      2004 Annual Research Report
  • [Journal Article] AGE down-regulation of monocyte RAGE expression and its association with diabetic complications in type 1 diabetes2004

    • Author(s)
      Miura, J.
    • Journal Title

      J.Diabetes Complications 18(1)

      Pages: 53-59

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture2004

    • Author(s)
      Kaji, T.
    • Journal Title

      Biol.Pharm.Bull. 27(11)

      Pages: 1763-1768

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 糖化蛋白による血管障害とその防止の分子機構2004

    • Author(s)
      武内 章彦
    • Journal Title

      血管 27(4)

      Pages: 125-130

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Development of an ELISA system for a circulating decoy receptor for AGE and its application to type I diabetic patients.

    • Author(s)
      Sakurai, S., et al.
    • Journal Title

      Diabetes Res.Clin.Pract. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 最新医学・別冊 新しい診断と治療のABC30 糖尿病合併症(門脇 孝 編)2005

    • Author(s)
      三浦順之助, 他
    • Total Pages
      269
    • Publisher
      最新医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] RNAi法とアンチセンス法-RNAの科学と応用(関根光雄, 多比良和誠 編)2005

    • Author(s)
      米倉 秀人, 他
    • Total Pages
      226
    • Publisher
      講談社サイエンティフィク社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 糖尿病カレントライブラリー(5) 糖尿病性細小血管症(羽田勝計,荒木栄一 編)2005

    • Author(s)
      山本 靖彦, 他
    • Total Pages
      225
    • Publisher
      講談社サイエンティフィク社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] RNAi法とアンチセンス法-RNAの科学と応用(関根光雄,多比良和誠 編)(アンチセンスDNAを用いた機能的遺伝子同定法-アンチセンスディスプレイ法の原理と適用-,pp.189-199)2005

    • Author(s)
      米倉秀人, 他
    • Total Pages
      226
    • Publisher
      談社サイエンティフィク社
    • Related Report
      2005 Annual Research Report
  • [Book] 新しい診断と治療のABC30(門脇孝編)(糖尿病細小血管症の成因-,pp.19-28)2005

    • Author(s)
      三浦順之助, 他
    • Total Pages
      250
    • Publisher
      最新医学社
    • Related Report
      2005 Annual Research Report
  • [Book] RNAi法とアンチセンス法-RNAの科学と応用(関根光雄,多比良和誠 編)2005

    • Author(s)
      米倉 秀人
    • Publisher
      講談社サイエンティフィク社(In press)
    • Related Report
      2004 Annual Research Report
  • [Book] International Congress Series 1262 (Atherosclerosis XIII)2004

    • Author(s)
      Yamamoto, Y. et al.
    • Publisher
      ELSEVIER SCIENCE, Amsterdam, The Netherlands
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Encyclopedia of Endocrine Diseases Vol.22004

    • Author(s)
      Hatakeyama, H. et al.
    • Publisher
      ELSEVIER SCIENCE, Amsterdam, The Netherlands
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 糖尿病 病態の分子生物学(門脇 孝編)2004

    • Author(s)
      米倉 秀人, 他
    • Total Pages
      161
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 医学の歩み・別冊 糖尿病・代謝症候群(門脇 孝, 小川佳宏, 下村伊一朗 編)2004

    • Author(s)
      山本 博, 他
    • Total Pages
      861
    • Publisher
      医師薬出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 老年医学Update2004-05(日本老年医学会雑誌編集委員会編)2004

    • Author(s)
      山本 靖彦, 他
    • Total Pages
      214
    • Publisher
      メジカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 糖尿病の進歩2004(日本糖尿病学会 編)2004

    • Author(s)
      山本 博, 他
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 循環器医が治療する糖尿病と大血管障害(代田浩之, 野出孝一 編)2004

    • Author(s)
      小川 智, 他
    • Publisher
      メジカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] International Congress Series 1262(Atherosclerosis XIII)2004

    • Author(s)
      Yamamoto, Y.
    • Total Pages
      4
    • Publisher
      Elsevier Science B.V., Amsterdam, The Netherlands
    • Related Report
      2004 Annual Research Report
  • [Book] Encyclopedia of Endocrine Diseases Vol.22004

    • Author(s)
      Hatakeyama, H.
    • Total Pages
      3
    • Publisher
      ELSEVIER SCIENCE, Amsterdam, The Netherlands
    • Related Report
      2004 Annual Research Report
  • [Book] 病態の分子生物学 糖尿病(門脇 孝編)2004

    • Author(s)
      米倉 秀人
    • Total Pages
      10
    • Publisher
      南山堂
    • Related Report
      2004 Annual Research Report
  • [Book] 老年医学Update 2004-05(日本老年医学会雑誌編集委員会編)2004

    • Author(s)
      山本 靖彦
    • Total Pages
      9
    • Publisher
      メジカルレビュー社
    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] RAGE阻害剤2006

    • Inventor(s)
      森川忠則, 他7名
    • Industrial Property Rights Holder
      竹田 雄一郎
    • Industrial Property Number
      2006-038671
    • Filing Date
      2006-02-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] RAGEポリペプチドの新規用途2006

    • Inventor(s)
      山本博, 他6名
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2006-049312
    • Filing Date
      2006-02-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] RAGEポリペプチドの新規用途2006

    • Inventor(s)
      山本博, 他6名
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2006-069908
    • Filing Date
      2006-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] RAGE阻害剤2006

    • Inventor(s)
      森川 忠則, 他7名
    • Industrial Property Rights Holder
      竹田 雄一郎
    • Industrial Property Number
      2006-038671
    • Filing Date
      2006-02-15
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] RAGEポリペプチドの新規用途2006

    • Inventor(s)
      山本 博, 他6名
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2006-049312
    • Filing Date
      2006-02-24
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] RAGEポリペプチドの新規用途2006

    • Inventor(s)
      山本 博, 他6名
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2006-069908
    • Filing Date
      2006-03-14
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 早期肺癌の術後予後検査方法2005

    • Inventor(s)
      久保裕司, 他7名
    • Industrial Property Rights Holder
      金沢大学, 東北大学
    • Industrial Property Number
      2005-363082
    • Filing Date
      2005-12-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 早期肺癌の術後予後査方法2005

    • Inventor(s)
      久保 裕司, 他7名
    • Industrial Property Rights Holder
      金沢大学 東北大学
    • Industrial Property Number
      2005-363082
    • Filing Date
      2005-12-16
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] 生活習慣病予知因子2004

    • Inventor(s)
      山本博, 他8名
    • Industrial Property Rights Holder
      金沢大学TLO
    • Industrial Property Number
      2004-158837
    • Filing Date
      2004-05-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 生活習慣病予知因子2004

    • Inventor(s)
      山本 博他8名
    • Industrial Property Rights Holder
      金沢大学TLO
    • Industrial Property Number
      2004-158837
    • Filing Date
      2004-05-28
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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