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Regulatory mechanisms of higher neuronal function in nematode C.elegans.

Research Project

Project/Area Number 16570150
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

ISHIHARA Takeshi  Kyushu University, Faculty of Science, Professor, 大学院・理学研究院, 教授 (10249948)

Co-Investigator(Kenkyū-buntansha) KOGA Makoto  Kyushu University, Faculty of Science, Assistant Professor, 大学院・理学研究院, 助教授 (60243888)
FUJIWARA Manbi  Kyushu University, Faculty of Science, Research Associate, 大学院・理学研究院, 助手 (70359933)
HIROTSU Takaaki  Kyushu University, Faculty of Science, Research Associate, 大学院・理学研究院, 助手 (70404035)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsC.elegans / neuron / learning / homeostasis / genetics / 行動 / 神経回路 / 学習 / チロシンキナーゼ
Research Abstract

Animals sense many environmental stimuli, and process the sensory information in the nervous system. This sensory processing includes selection of appropriate information, proper integration, and modification by experience or memory. To elucidate molecular and neuronal mechanisms for such sensory processing, we are conducting genetic studies on behavior and body size, both of which are under the sensory control in C.elegans.
In C.elegans, a secretory protein, HEN-1, and a receptor tyrosine kinase, SCD-2, regulate sensory integration of two sensory signals : aversive copper ion and an attractive odorant diacetyl. In addition, they are required for an associative learning after conditioned with NaCl and starvation. By expressing wild type scd-2 cDNA in scd-2 mutants driven by specific promoters, we found that SCD-2 functions in a few pairs of interneurons at the adult stage. In this year, we investigated molecules that function in these interneurons to regulate sensory processing. Glutamate receptors are candidates of those molecules, because, in C.elegans, three types of glutamate receptors, metabotropic receptors, cationic receptors and anionic receptors, are known to function in the central nervous system. Among those, we found that an AMPA type cationic receptor, GLR-1, regulates the sensory integration in a distinct pathway from HEN-1/SCD-2. In addition, we found that a Cl- channel type glutamate receptor, which has significant homology with GABA_A receptors, also regulates the sensory integration.
In C.elegans, body size is regulated by a TGFb homologue, DBL-1, and downstream transcriptional regulator SMAD, SMA-2 and SMA-4. We screened mutant with defects in this pathway by monitoring an expression level of LON-1, which is regulated by SMA-2 and SMA-4, and identified a new regulatory component, qj1. We revealed that qj1 is a novel protein expressed in hypodermis, and negatively regulates SMA-2 and SMA-4 to control body size of C.elegans.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (14 results)

All 2005 2004

All Journal Article (14 results)

  • [Journal Article] The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans.2005

    • Author(s)
      Murayama T. et al.
    • Journal Title

      J.Mol.Biol 346

      Pages: 677-687

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] FLR-4, a novel Serine/Threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans.2005

    • Author(s)
      Take-Uchi M, et al.
    • Journal Title

      Mol Biol Cell 16

      Pages: 1355-1365

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Neural circuit-dependent odor adaptation in C.elegans is regulated by the Ras-MAPK pathway.2005

    • Author(s)
      Hirotsu T. et al.
    • Journal Title

      Genes Cells 10

      Pages: 517-530

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans.2005

    • Author(s)
      Yabe T., et al.
    • Journal Title

      Development 132

      Pages: 3197-3207

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] MBR-1, a Novel Helix-Turn-Helix Transcription Factor, Is Required for Pruning Excessive Neurites in Caenorhabditis elegans.2005

    • Author(s)
      Kage E., et al.
    • Journal Title

      Current Biology 15

      Pages: 1554-1559

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Molecular mechanisms of sensory integration and learning.2005

    • Author(s)
      Ishihara et al.
    • Journal Title

      Clinical Neuroscience (in Japanese) Vol.23,No.4

      Pages: 468-468

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Multidrug resistance-associated protein MRP-1 regulates dauer diapause by its export activity in Caenorhabditis elegans2005

    • Author(s)
      Yabe T.et al.
    • Journal Title

      Development 132

      Pages: 3197-3207

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neural circuit-dependent odor adaptation in C.elegans is regulated by the Ras-MAPK pathway.2005

    • Author(s)
      Hirotsu T.et al.
    • Journal Title

      Genes Cells 10

      Pages: 517-530

    • Related Report
      2005 Annual Research Report
  • [Journal Article] MBR-1, a Novel Helix-Turn-Helix Transcription Factor Is Required for Pruning Excessive Neurites in Caenorhabditis elegans.2005

    • Author(s)
      Kage E.et al.
    • Journal Title

      Current Biology 15

      Pages: 1554-1559

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans.2005

    • Author(s)
      Murayama T.
    • Journal Title

      J.Mol.Biol 346

      Pages: 677-687

    • Related Report
      2004 Annual Research Report
  • [Journal Article] FLR-4, a novel Serine/Threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans.2005

    • Author(s)
      Take-Uchi M.
    • Journal Title

      Mol Biol Cell 16・3

      Pages: 1355-1365

    • Related Report
      2004 Annual Research Report
  • [Journal Article] TBX2/TBX3 transcriptional factor homolog controls olfactory adaptation in Caenorhabditis elegans.2004

    • Author(s)
      Miyahara, K. et al.
    • Journal Title

      Journal of Neurobiology 58

      Pages: 392-402

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Studies on regulatory mechanisms of learning and memory in model animals.2004

    • Author(s)
      Ishihara et al.
    • Journal Title

      Molecular Medicine (in Japanese) 41,No.9

      Pages: 1073-10798

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] モデル動物を用いた記憶・学習にかかわる制御機構の解析2004

    • Author(s)
      石原 健
    • Journal Title

      Molecular Medicine 41・9

      Pages: 1073-1079

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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