| Project/Area Number |
16570199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
生理人類学
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| Research Institution | Wakayama Medical University (2005-2006)
Kansai Medical University (2004) |
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Principal Investigator |
NISHIO Nobuhiro Wakayama Medical University, Department of Medicine, Lecturer (00278631)
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| Co-Investigator(Kenkyū-buntansha) |
KONO Hirao Kansai Medical University, Department of Medicine, Lecturer (30148522)
KODA Katsuyasu Kinki University, School of Medicine, Associate Professor (60273182)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Allergen / physical function / adaptation of environment / isocyanate / fasting / cytokine |
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| Research Abstract |
The human has spent in natural environment in their history, and has adjusted to the environment The human has had their own physical function adjust to the stress in the natural environment including hunger. The development of science and technology has produced a new antigen, it has not existed past in the natural world. An increase of the allergic disease in recent years may have been caused by the change in such an environment Isocyanate, including toluene diisocyanate (TDI), is common causes of occupational asthma and contact dermatitis. It is reported that TDI induce both respiratory hypersensitivity and contact sensitivity in mice and guinea pigs. In laboratory animals, it is well known that suppressive effects on allergic inflammation by dietary restriction. In the present study, we planned to observe the suppressive effect of short-term fasting on TDI-induced dermatitis in mice.
The TDI solutions were applied to the shaved back of mice. Later, the TDI solutions were applied to the ventral side of the ear. Ear swelling was measured 24 hours after the challenge. The ear swelling rate in mice with fasting after the challenge were less than in mice with ad libitum feeding. From these findings, dietary restriction may be effective to isocyanate-induced respiratory hypersensitivity.
Because it was confirmed that an allergic inflammation is suppressed by the energy restriction, the effect of energy restriction is expected as an occupational allergen in both cases of an acute allergic inflammation by a large amount of exposure of TDI and of a chronic allergic inflammation by the chronic exposure of that. For the introduction of the energy restriction and a short-term fasting to the patient of immune disease is already examined, it is thought that the energy restriction has enough utility for the human.
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