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Elucidation of cardiac muscle fibrosis mechanism by renin-angiotensin system through chymase

Research Project

Project/Area Number 16580268
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionKitasato University

Principal Investigator

UECHI Masami  Kitasato University, Facaulty of Veterinary Medicine and Animal Sciences., 獣医畜産学部, 助教授 (90296426)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsheart failure / hamster / cardiac fibrosis / renin-angiotensin system / angiotensin receptor / aldosteron / 心筋線維化 / レニン-アンジオテンシン
Research Abstract

In chronic heart failure, renin- angiotensin (RAS) system is enhanced. Angiotensin converting enzyme and chymase are present in RAS system, and these enzymes may affect pathophysiologically in cardiac failure. In this study, response to tissue RAS of ACE inhibitor (enalapril) and Ang II type receptor blocker (ARB : Candesartan) were examined. Hamsters with an aortic coarctation were given ACE inhibitor and ARB. Cardiac muscle hyperplasia depression was observed in ACE inhibitor and ARB administrated group by echocardiography, and the decrease that was significant in heart / body weight ratio was observed. The left ventricle ACE and the chymase activity were not inhibited by ACE inhibitor and ARB. However, decreased systolic blood pressure and decrease of left ventricle Ang II were observed by ACE inhibitor and ARB, and this tendency was more massive in a combined medication. These results suggested increasing afterload and tissue Ang II contribute cardiac hypertrophy in pressure overload.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (14 results)

All 2006 2003

All Journal Article (14 results)

  • [Journal Article] Enhanced gene expression of myocardial matrix metalloproteineses 2 and 9 after acute treatment with doxorubicine in mice2006

    • Author(s)
      Kizaki K, Ito R, Okada M, Yoshioka K, Uchide T, Temma K, Mutoh K, Uechi M, Hara Y
    • Journal Title

      Pharmacological Research (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cardiovascular Effects of Phosphodiesterase III inhibitor in Presence of Carvedilol in Dogs.2006

    • Author(s)
      Uechi M, Hori Y, Fujimoto K, Saitou Y, Maekawa S
    • Journal Title

      Journal of Veterinary Medical Science 68 (6) (In press)

    • NAID

      110004763153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gender difference of cardiac fibrosis induced by sympathetic stimulation.2006

    • Author(s)
      Ysutomo Hori, Masami Uechi, Takashi Ebisawa, Shigeki Yamano, Kazuki Yoshioka, Kenichirou Mutou
    • Journal Title

      American Journal of Physiology. (投稿中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enhanced gene expression of myocardial matrix metalloproteineses 2 and 9 after acute treatment with doxorubicine in mice.2006

    • Author(s)
      Kizaki K, Ito R, Okada M, Yoshioka K, Uchide T, Temma k, Mutoh K, Uechi M, Hara Y.
    • Journal Title

      Pharmacological Research. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cardiovascular Effects of Phosphodiesterase III inhibitor in Presence of Carvedilol in Dogs.2006

    • Author(s)
      Uechi M, Hori Y, Fujimoto K, Saitou Y, Maekawa S.
    • Journal Title

      Journal of Veterinary Medical Science. 68(6)(In press)

    • NAID

      110004763153

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gender difference of cardiac fibrosis induced by sympathetic stimulation.2006

    • Author(s)
      Yasutomo Hori, Masami Uechi, Takashi Ebisawa, Shigeki Yamano, Kazuki Yoshioka, Kenichirou Mutou
    • Journal Title

      American Journal of Physiology. (submitted)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enhanced gene expression of myocardial matrix metalloproteinases 2 and 9 after acute treatment with doxorubicin in mice2006

    • Author(s)
      Kizaki K, Ito R, Okada M, Yoshioka K, Uchide T, Temma K, Mutoh K, Uechi M, Hara Y.
    • Journal Title

      Pharmacological Research (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cardiovascular Effects of Phosphodiesterase III inhibitor in Presence of Carvedilol in Dogs.2006

    • Author(s)
      Uechi M, Hori Y, Fujimoto K, Saitou Y, Maekawa S.
    • Journal Title

      Journal of Veterinary Medical Science 68(6)(In press)

    • NAID

      110004763153

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A Comparison of Angiotensin Converting Enzyme and Chymase Activity in the Heart of Cats,Dogs and Hamsters.2003

    • Author(s)
      Aramaki Y, Uechi M, Takase K
    • Journal Title

      Journal of Veterinary Medical Science 65 (10)

      Pages: 1115-1118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Effects of the Loop Diuretics Furosemide and Torasemide on Diuresis in Dogs and Cats.2003

    • Author(s)
      Uechi M, Matsuoka M, Kuwajima E, Kaneko T, Yamashita K, Fukushima U, Ishikawa Y
    • Journal Title

      Journal of Veterinary Medical Science 65 (15)

      Pages: 1057-1061

    • NAID

      110003886126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A Comparison of Angiotensin Converting Enzyme and Chymase Activity in the Heart of Cats, Dogs and Hamsters.2003

    • Author(s)
      Aramaki Y, Uechi M, Takase K.
    • Journal Title

      Journal of Veterinary Medical Science. 65(10)

      Pages: 1115-1118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The Effects of the Loop Diuretics Furosemide and Torasemide on Diuresis in Dogs and Cats.2003

    • Author(s)
      Uechi M, Matsuoka M, Kuwajima E, Kaneko T, Yamashita K, Fukushima U, Ishikawa Y.
    • Journal Title

      Journal of Veterinary Medical Science. 65(15)

      Pages: 1057-1061

    • NAID

      110003886126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A Comparison of Angiotensin Converting Enzyme and Chymase Activity in the Heart of Cats, Dogs and Hamsters.2003

    • Author(s)
      Aramaki Y, Uechi M, Takase K.
    • Journal Title

      Journal of Veterinary Medical Science 65(10)

      Pages: 1115-1118

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Effects of the Loop Diuretics Furosemide and Torasemide on Diuresis in Dogs and Cats.2003

    • Author(s)
      Uechi M, Matsuoka M, Kuwajima E, Kaneko T, Yamashita K, Fukushima U, Ishikawa Y.
    • Journal Title

      Journal of Veterinary Medical Science 65(15)

      Pages: 1057-1061

    • NAID

      110003886126

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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