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Synthetic studies for functional elucidation of RNA catalysis and H4 receptor

Research Project

Project/Area Number 16590024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionOsaka University of Pharmaceutical Sciences

Principal Investigator

HARUSAWA Shinya  Osaka University of Pharmaceutical Sciences, 薬学部, Prof. (90167601)

Co-Investigator(Kenkyū-buntansha) YAMATODANI Atsushi  Osaka University, Faculty of Medicine, Prof. (30116123)
栗原 拓史  大阪薬科大学, 薬学部, 教授 (90067281)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,610,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsribozyme / imidazole / C-nueleoside / phosphoramidite / histamine / H_3 / H_4 / antagonist / ホスホロアミダイド / C-ヌグレオシド / マトリックス / マススペクトル / H_3
Research Abstract

A novel C4-linked imidazole ribonucleoside phosphoramidite was designed and synthesized. This phosphoramidite was successfully incorporated the imidazole moiety into VS and hairpin ribozymes. As the modified imidazole ribozymes thus obtained indicated the activities in both cleavage and ligation, the data provided good evidence for general acid-base catalysis by their natural nucleobases. Further, the second stable imidazole ribonucleoside phosphoramidite has designed and synthesized bearing a cyanoethyl group as a protective group at 2'-OH group.
On the other hand, novel histamine H_3 antagonists having two chiral centers and stable chair conformations were designed and synthesized. Among them, a (2S,2R)-N-alkyl derivative (OUP-153), which increased histamine release to 180-200% of basal levels, was found as a novel histamine H_3 antagonist. In addition, S-alkyl-N-alkylisothioureas were efficiently synthesized via a synthetic approach using 3-phenylpropionyl isothiocyanate (PPI). The utility of the approach was proved by the synthesis of clobenpropit, a potent H_3 antagonist and its analogues.

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (70 results)

All 2008 2007 2006 2005 2004 Other

All Journal Article (46 results) (of which Peer Reviewed: 17 results) Presentation (20 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Efficient Approaches to S-Alky1-N-alkylisothioureas:Syntheses of Histamine H_3 Antagonist Clobenpropit and Its Analogues2008

    • Author(s)
      H.Yoneyama
    • Journal Title

      J.Org.Chem. 73

      Pages: 2096-2104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficient Approaches to S-Alkyl-N-alkylisothioureas : Syntheses of Histamine H3 Antagonist Clobenpropit and Its Analogues2008

    • Author(s)
      H. Yoneyanma
    • Journal Title

      J. Org. Chem. 73

      Pages: 2096-2104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Efficient Approaches to S-Alkyl-N-alkylisothioureas:Syntheses of Histamine H_3 Antagonist Clobenpropit anld Its Analogues2008

    • Author(s)
      Hiroki Yoneyama
    • Journal Title

      The Jounal of Organic Chemistry 73

      Pages: 2096-2104

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA folding and the origin of catalytic activity in the hairpinribozyme2007

    • Author(s)
      T.J.Wilson
    • Journal Title

      Blood Cells, Molecules, and Diseases 38

      Pages: 8-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mass Determination of Phosphoramidites:Effects of the Metal Ion in the Matrix And Applicability on FABMS2007

    • Author(s)
      M.Fujitake
    • Journal Title

      Bull.Osaka.Univ.Pharm.Sci. 1

      Pages: 107-112

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of Novel 4(5)-(5-Aminotetrahydropyran-2-y1)imidazole Derivatives and Their in vivo Release of Neuronal Histamine Measured by Brain Microdialysis2007

    • Author(s)
      S.Harusawa
    • Journal Title

      Chem.Pharm.Bull. 55

      Pages: 1245-1253

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] RNA folding and the origin of catalytic activity in the hairpin ribozyme.2007

    • Author(s)
      T. J. Wilson
    • Journal Title

      Blood Cells, Molecules, and Diseases 38

      Pages: 8-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mass Determination of Phosphoramidites: Effects of the Metal Ion in the Matrix And Applicability on FABMS.2007

    • Author(s)
      M. Fujitake
    • Journal Title

      Bull. Osaka. Univ. Pharm. Sci. 1

      Pages: 107-112

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of Novel 4(5)-(5-Aminotetrahydropyran-2-yl)imidazole Derivatives and Their in vivo Release of Neuronal Histamine Measured by Brain Microdialysis2007

    • Author(s)
      S. Harusawa
    • Journal Title

      Chem. Pharm. Bull. 55

      Pages: 1245-1253

    • NAID

      110006366548

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of Novel 4 (5)-(5-Aminotetrahydropyran-2-yl)imidazole Derivatives and Their In Vivo Release of Neuronal Histamine Measured by Brain Microdialysis2007

    • Author(s)
      Shinya Harusawa
    • Journal Title

      Chemical Pharmaceutical Bulletin 55

      Pages: 1245-1253

    • NAID

      110006366548

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA folding and the origins of catalytic activity in the hairpinribozyme2007

    • Author(s)
      Timothy J.Wilson
    • Journal Title

      Blood Cells, Molecules, and Diseases 38

      Pages: 8-14

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mass Determination of Phosphoramidites:Effects of the Metal Ion in the Matrix and Application on FABMS2007

    • Author(s)
      Mihoyo Fujitake
    • Journal Title

      Bulletin of Osaka University of Pharmaceutical Sciences 1

      Pages: 107-112

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA folding and the origin of catalytic activity in the hairpinribozyme2007

    • Author(s)
      Timothy J. Wilson
    • Journal Title

      Blood Cell, Molecules, and Diseases 38・5

      Pages: 8-14

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mass Detemiination of Phosphoramidites : Effects of the Metal Ion in the Matrix and Applicability on FABMS2007

    • Author(s)
      Mihoyo Fjitake
    • Journal Title

      Bull. Osaka. Univ. Pharm. Sci. 1

      Pages: 107-112

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nucleobase catalysis in the hairpin ribozyme2006

    • Author(s)
      T.J.Wiilson
    • Journal Title

      RNA 12

      Pages: 980-987

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] β-Stereoselective synthesis of pyrazole C-nucleoside via diazofulvene intermediates2006

    • Author(s)
      S.Harusawa
    • Journal Title

      Synthesis

      Pages: 793-798

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mass Determination of Phosphoramidites2006

    • Author(s)
      S.Harusawa
    • Journal Title

      Current Protocols in Nucleic Acid Chemistry

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nucleobase catalysis in the hairpin ribozyme.2006

    • Author(s)
      T. J. Wiilson
    • Journal Title

      RNA 12

      Pages: 980-987

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] β-Stereoselective synthesis of pyrazole C-nucleoside via diazofulvene intermediates.2006

    • Author(s)
      S. Harusawa
    • Journal Title

      Synthesis

      Pages: 793-798

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mass Determination of Phosphoramidites.2006

    • Author(s)
      S. Harusawa
    • Journal Title

      Current Protocols in Nucleic Acid Chemistry

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Efficient and β-stereoselective synthesis of pyrazole C-nucleosides2006

    • Author(s)
      Shinya Harusawa
    • Journal Title

      Synthesis 2006・5

      Pages: 793-798

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nucleobase catalysis in the hairpin ribozyme2006

    • Author(s)
      Timothy J. Wilson
    • Journal Title

      RNA 12・6

      Pages: 980-987

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Review : Mass determination of phosphoramidites2006

    • Author(s)
      Shinya Harasawa
    • Journal Title

      Current Protocols in Nucleic Acid Chemistry Unit10・11

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Efficient and β-stereoselective synthesis of pyrazole C-nucleosides2006

    • Author(s)
      Shinya Harusawa
    • Journal Title

      Synthesis (5)

      Pages: 793-798

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nucleobase catalysis in the hairpin ribozyme2006

    • Author(s)
      Timothy J.Wilson
    • Journal Title

      RNA (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Accurate molecular weight measurements of nucleoside phosphoramidites:a suitable matrix of mass spectrometry2005

    • Author(s)
      M.Fujitake
    • Journal Title

      Tetrahedron 61

      Pages: 4689-4699

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nucleobase participation in ribozyme catalysis2005

    • Author(s)
      Z.Zhao
    • Journal Title

      J.Am.Chem.Soc. 127

      Pages: 5026-5027

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of novel C4-linked imidazole ribonucleoside phosphoramidite for probing general acid and base catalysis in ribozyme2005

    • Author(s)
      L.Araki
    • Journal Title

      Tetrahedron 61

      Pages: 11976-11985

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Accurate molecular weight measurements of nucleoside phosphoramidites : a suitable matrix of mass spectrolnetry.2005

    • Author(s)
      M. Fujitake
    • Journal Title

      Tetrahedron Lett. 61

      Pages: 4689-4699

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nucleobase participation in ribozyme catalysis.2005

    • Author(s)
      Z. Zhao
    • Journal Title

      J. Am. Chem. Soc. 127

      Pages: 5026-5027

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of novel C4-linked imidazole ribonucleoside phosphoramidite for probing general acid and base catalysis in ribozyme.2005

    • Author(s)
      L. Araki
    • Journal Title

      Tetrahedron Lett. 61

      Pages: 11976-11985

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Accurate molecular weight measurements of nucleoside phosphoramidite : a suitable matrix of mass spectrometry2005

    • Author(s)
      Mihoyo Fujitake
    • Journal Title

      Tetrahedron 61

      Pages: 4689-4699

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nucleobase participation in ribozyme catalysis2005

    • Author(s)
      Zheng-yun Zhao
    • Journal Title

      J.Am.Chem.Soc. 127

      Pages: 5026-5027

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Synthesis of novel C4-linked imidazole ribonucleoside phosphoramidites for probing general acid and base catalysis in ribozyme2005

    • Author(s)
      Lisa Araki
    • Journal Title

      Tetrahedron 61

      Pages: 11976-11985

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Accurate molecular weight measurements of nucleoside phosphoramidites : a suitable matrix of mass spectrometry2005

    • Author(s)
      Mihoyo Fujitake
    • Journal Title

      Tetrahedron 60(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nucleobase participation in ribozyme catalysis2005

    • Author(s)
      Zheng-yun Zhao
    • Journal Title

      J.Am.Chem.Soc. 127(in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intracerebroventricular administration of histamine H_3 receptor antagonists decreases seizures in rat methods of epilepsia2004

    • Author(s)
      C.Harada
    • Journal Title

      Methods Find.Exp.Clin.Pharmacol. 26

      Pages: 263-270

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Synthesis of C4-linked imidazole ribonucleoside phosphoramidite with pivaloyloxy methy1 (POM) group2004

    • Author(s)
      L.Araki
    • Journal Title

      Tetrahedron Lett. 45

      Pages: 2657-2661

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage2004

    • Author(s)
      S.Harusawa
    • Journal Title

      Tetrahedron 60

      Pages: 11911-11922

    • NAID

      130006996706

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Intracerebroventricular administration of histamine H_3 receptor antagonists decreases seizures in rat methods of epilepsia.2004

    • Author(s)
      C. Harada
    • Journal Title

      Methods Find. Exp. Clin. Pharmacol 26

      Pages: 263-270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of novel C4-linked imidazole ribonucleoside phosphoramidite with pivaloyloxymethyl(POM) group.2004

    • Author(s)
      L. Araki
    • Journal Title

      Tetrahedron Lett. 45

      Pages: 2657-2661

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage.2004

    • Author(s)
      S. Harusawa
    • Journal Title

      Tetrahedron Lett. 60

      Pages: 11911-11922

    • NAID

      130006996706

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Synthesis of C4-linked imidazole ribonucleoside phosphoramidite with pivaloyloxymethyl (POM) group2004

    • Author(s)
      Lisa Araki
    • Journal Title

      Tetrahedron Lett. 45・12

      Pages: 2657-2661

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Design and synthesis of an aminobenzo-15-crown-5-labeled estradiol tethered with disulfide linkage2004

    • Author(s)
      Shinya Harusawa
    • Journal Title

      Tetrahedron 60・51

      Pages: 11911-11922

    • NAID

      130006996706

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Intracerebroventricular Administration of Histamine H_3 receptor Antagonists Decreases Seizures in Rat Models of Epilepsia2004

    • Author(s)
      Chie Harada
    • Journal Title

      Methods Find Exp Clin Pharmacol 26・4

      Pages: 263-270

    • Related Report
      2004 Annual Research Report
  • [Journal Article] H_4リガンドの創製を目指して2004

    • Author(s)
      荒木 理佐
    • Journal Title

      財団報 21

      Pages: 21-21

    • Related Report
      2004 Annual Research Report
  • [Presentation] 機能性C4(5)-イミダゾール誘導体の創製研究:ヒスタミンH3,H4リガンド及びRNA触媒プローブへの応用2007

    • Author(s)
      春沢 信哉
    • Organizer
      大阪薬科大学ハイテク・リサーチ・センター平成19年度公開シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2007-12-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthetic studies of C4(5)-imidazole derivatives: Application to histamine H_3, H_4-ligands and RNA probes.2007

    • Author(s)
      S. Harusawa
    • Organizer
      Symposium of high technology research(Osaka Univ. of Pharm. Sci.)
    • Place of Presentation
      Osaka
    • Year and Date
      2007-12-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 機能性C4(5)-イミダゾール誘導体の創製研究:ヒスタミンH3, H4リガンド及びRNA触媒プローブへの応用2007

    • Author(s)
      春沢 信哉
    • Organizer
      大阪薬科大学ハイテク・リサーチ・センター平成19年度公開シンポジュウム
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規テトラヒドロピラニルイミダゾール誘導体の合成とヒスタミンH3アンタゴニスト活性2007

    • Author(s)
      春沢 信哉
    • Organizer
      第57回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2007-11-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] イソチオウレアの新規合成法の開発-Clobenpropitの効率合成2007

    • Author(s)
      米山 弘樹
    • Organizer
      第57回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒスタミンH3アンタゴニストを目指したホウ素クラスター含有イソチオウレアの合成2007

    • Author(s)
      荒木 理佐
    • Organizer
      第57回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪薬科大学
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] イソチオウレアスペーサーを持つH_3アンタゴニストの新規合成法の開発2007

    • Author(s)
      米山 弘樹
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒスタミンH4受容体発見による選択的リガンド開発とその現状2007

    • Author(s)
      春沢 信哉
    • Organizer
      第11回日本ヒスタミン学会
    • Place of Presentation
      富山
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two novel synthetic methods of internal isothioureas as H_3 antagonists.2007

    • Author(s)
      H. Yoneyama
    • Organizer
      33th Symposium on progress in organic reactions and syntheses-applications in the life sciences-
    • Place of Presentation
      Nagasaki
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development and current sitsuation of histamine H4 receptor ligands.2007

    • Author(s)
      S. Harusawa
    • Organizer
      11th The Japan histamine research society
    • Place of Presentation
      Toyama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イソチオウレアスペーサーを持つH_3アンタゴニストの新規合成法の開発2007

    • Author(s)
      米山 弘樹
    • Organizer
      第33回反応と合成の進歩シンポジゥム
    • Place of Presentation
      長崎ブリックホール
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒスタミンH4受容体発見による選択的リガンド開発とその現状2007

    • Author(s)
      春沢 信哉
    • Organizer
      第11回日本ヒスタミン学会
    • Place of Presentation
      富山市民プラザ
    • Related Report
      2007 Annual Research Report
  • [Presentation] in vivoアッセイにおけるヒスタミンH_3-受容体に対する4(5)-(5-アミノテトラヒドロピラン-2-イル)イミダゾールの立体配置と薬理作用の関係2005

    • Author(s)
      春沢 信哉
    • Organizer
      第125年会 日本薬学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イミダゾール置換VSリボザイムの合成と触媒機能解明の新手法の開発2005

    • Author(s)
      荒木 理佐
    • Organizer
      第31回反応と合成の進歩シンポジウム
    • Place of Presentation
      神戸
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between configurations and pharmacological effects of 4(5)-(5-aminotetrahydropyran-2-yl)imidazoles against in vivo assay.2005

    • Author(s)
      S. Harusawa
    • Organizer
      125th The pharamaceutical Society of Japan
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of imidazole modified VS ribozyme and its application for a new chemical strategy probing catalytic activity in ribozyme.2005

    • Author(s)
      L. Araki
    • Organizer
      31th Symposium on progress in organic reactions and syntheses-applications in the life sciences-
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of novel C4-linked imidazole ribonucleoside phosphoramidite with pival oyloxymethy1(POM) group2004

    • Author(s)
      L.Araki
    • Organizer
      Fifteenth International Conference on Organic Synthesis (IUPAC ICOS-15, Nagoya)
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ジスフィド結合で架橋したクラウンエーテル標識エストラジオールの合成2004

    • Author(s)
      春沢 信哉
    • Organizer
      第30回反応と合成の進歩シンポジウム
    • Place of Presentation
      札幌
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Synthesis of novel C4-linked imidazole ribonucleoside phosphoramidite with pivaloyloxymethyl(POM) group.2004

    • Author(s)
      L. AraIci
    • Organizer
      Fifteenth International Conference on Organic Synthesis(IUPAC ICOS-15)
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Design and synthesis of an aminobenzo-15-crown-5-labeled Estrdiol tethered with disulfide linkage.2004

    • Author(s)
      S. Harusawa
    • Organizer
      30th Symposium on progress in organic reactions and syntheses-applications in the life sciences-
    • Place of Presentation
      Sapporo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Mass determination of phosphoramidites (Unit 10.11)2006

    • Author(s)
      Shinya Harusawa
    • Total Pages
      26
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2005 Annual Research Report
  • [Book] 有機薬品製造学 第4版2004

    • Author(s)
      栗原 拓史
    • Total Pages
      313
    • Publisher
      廣川書店
    • Related Report
      2004 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.oups.ac.jp/kenkyu/kenkyuushitu/gousei.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.oups.ac.jp/kenkyu/kenkyuushitu/gousei.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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