| Project/Area Number |
16590147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Oita University |
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Principal Investigator |
KATO Seiji Oita University, Faculty of Medicine, Professor, 医学部, 教授 (60034956)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Tuyosi Oita University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (20264335)
SHIMODA Hiroshi Oita University, Faculty of Medicine, Research Associate, 医学部, 助手 (20274748)
JI Rui-Chen Oita University, Faculty of Medicine, Research Associate, 医学部, 助手 (60305034)
松本 有史 大分大学, 医学部, 講師 (10239121)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Lymphatic vessel / Lymphangiogenesis / Cancer metastasis / Vascular endothelial growth factor / Endothelial specific marker / Histochemistry / Podoplanin / VEGF-C / 酵素組織化学 / 免疫組織化学 |
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| Research Abstract |
The recent development and application of new histochemical methods for identifying lymphatics using endothelial specific markers have enabled the distinction between lymphatic and blood vessels at the capillary level, resulting in marked advance in the study of lymphatics. In particular, several functional molecules specifically expressed and localized in lymphatic endothelial cells, such as 5'-nucleotidase, lymphatic endothelial growth factor receptor-1 tyrosine kinase, vascular endothelial growth factor receptor-3, podoplanin and Prox-1, have been identified. The biology of lymphangiogenesis, particularly the mechanism of its regulation, is very important in understanding the formation of the lymphatic system as a biological regulation system transporting tissue fluid and wandering cells, including lymphocytres, and disease involving lymphangiogenesis. The understanding of the molecular mechanism of lymphangiogenesis and the elucidation of the development of normal and pathological tissues are expected to lead to the development of therapy for intractable diseases, such as malignant tumors and lymphedema. We examined the histochemical insight into the field of lymphangiogenesis, with special emphasis on the novel and reliable lymphatic endothelial cell markers, as well as on lymphatic regeneration after experimental injury.
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