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An integrative study on the role of spinal cord in neural mechanisms involved in mental sweating of humans.

Research Project

Project/Area Number 16590183
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionAichi Medical University

Principal Investigator

SUGENOYA Junichi  Aichi Medical University, School of Medicine, Professor (50109352)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Takaaki  Aichi Medical University, School of Medicine, Associate Professor (60199875)
IWASE Satoshi  Aichi Medical University, School of Medicine, Associate Professor (90184879)
NISHIMURA Naoki  Aichi Medical University, School of Medicine, Assistant Professor (40278362)
INUKAI Yoko  Aichi Medical University, School of Medicine, Assistant Professor (10308950)
SATO Maki  Aichi Medical University, School of Medicine, Research Associate (60351102)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordselectroacupuncture / spinal cord / mental sweating / skin pressure reflex / skin sympathetic nerve activity / mental stress / 鍼通電 / ストレス反応 / 発汗 / 汗腺 / 精神性ストレス / 皮膚血流量 / 脊髄反射 / 発汗神経
Research Abstract

Roles of spinal cord in neural mechanisms involved in mental sweating were studied by skin pressure (SP) and acupuncture stimulation (AS). Series I: the pattern of the suppression of sweating on palm and sole elicited by SP was examined. When 13 skin sites on the lateral body line located from head to hock were pressed, palmar sweating was suppressed ispsilaterally by pressure at C3 to L3 segmental levels, confirming that SP suppresses palmar sweating, as well as thermal sweating, via spinal mechanisms. Series II: AS at 5Hz and 100Hz is known to suppress palmar and plantar sweating via the mechanisms located below the higher center for sweating. To determine whether the site of action is located at spinal cord or sweat gland, we examined the responsiveness of sweat glands to neural activities by analyzing skin sympathetic nerve activity (SSNA), which was recoded by a microelectrode technique. The correlation between the rate of rise of sweat expulsion and the amplitude of the corresponding SSNA burst revealed that the slope of the regression line was not altered by AS at 5Hz or 100Hz. This substantiates that AS acts on spinal mechanisms. Series III: AS frequencies effective in sweat-suppression were examined. AS at 25Hz suppressed sweating via higher central mechanisms, whereas that at 300Hz failed to suppress it. Series IV: effects of AS on cutaneous blood flow (CBF) were examined. AS at 5Hz and 100Hz suppressed CBF on the sole, whereas they failed to suppress on the palm. It was concluded that spinal cord exhibits integrative functions as the centers of spinal reflex. Probably, sensory signals originating from various type of mechanoreceptor enter intermediolateral neurons in spinal cord, and modify the descending sympathetic signals at same segmental levels. However, integrative mechanisms may be different between regulatory functions.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (32 results)

All 2007 2006 2005 2004 Other

All Journal Article (27 results) Book (5 results)

  • [Journal Article] Modifications of immunological and neuroendocrine parameters induced by head-down bed rest in human healthy volunteers2007

    • Author(s)
      Kanikowska D et al.
    • Journal Title

      J. Physiol. Sci. 57 (Sup)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity2006

    • Author(s)
      Daisuke Michikami
    • Journal Title

      Am J Physiol Circ Physiol 291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity.2006

    • Author(s)
      Daisuke Michikami, Atsunori Kamiya, Toru Kawasa, Masashi Inagaki, Toshiaki Shindo, Kenta Yamamoto, Hideto Ariumi, Satoshi Iwase, Junichi Sugenoya, Kenji Sunagawa, Masaru Sugimachi
    • Journal Title

      Am J Physiol Circ Physiol 291

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity2006

    • Author(s)
      Disaku Michikami et al.
    • Journal Title

      Am J Physiol Circ Physiol 291

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 睡眠時における腹部温罨方が若年女性の胃電図に及ぼす影響2006

    • Author(s)
      清水祐樹, ほか
    • Journal Title

      自律神経 43・6

      Pages: 471-477

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ミストサウナが運動中のヒトの循環動態、体温調節能、および代謝に及ぼす影響2006

    • Author(s)
      川原ゆう子, ほか
    • Journal Title

      自立神経 41・6

      Pages: 344-351

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 温熱性発汗の調節機構2006

    • Author(s)
      菅屋潤壹
    • Journal Title

      発汗学 13・1

      Pages: 18-24

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 日常的な運動習慣のない若年女性における発汗能の季節変動2006

    • Author(s)
      谷口裕美子, ほか
    • Journal Title

      発汗学 13・1

      Pages: 25-27

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Low and high frequency acupuncture stimulation inhibits mental stress-induced sweating in humans via different mechanisms2005

    • Author(s)
      Akihiro Ogata
    • Journal Title

      Autonomic Neuroscience:Basic and Clinical 104

      Pages: 189-196

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of body posture on local sweating and sudomotor outflow as estimated using sweat expuslions2005

    • Author(s)
      Yoko Inukai
    • Journal Title

      Autonomic Neuroscience:Basic and Clinical 119

      Pages: 48-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] サーモグラフを用いた温熱性発汗部における単-汗腺活動の観察法2005

    • Author(s)
      西山 哲成
    • Journal Title

      Biomedical Thermology 24

      Pages: 34-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Low and high frequency acupuncture stimulation inhibits mental stress-induced sweating in humans via different mechanisms.2005

    • Author(s)
      Akihiro Oaata, Junichi Suaenova, Naoki Nishimura
    • Journal Title

      Autonomic Neuroscience : Basic and Clinical 104

      Pages: 189-196

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of body posture on local sweating and sudomotor outflow as estimated using sweat expulsions.2005

    • Author(s)
      Yoko Inukai, Junichi Sugenoya, Masko Kato, Naoki Nishimura, Tetsunari Nishiyama, Takaaki Matsumoto, Miki Sato, Akihiro Ogata, Yumiko Taniguchi, Atsushi Osada
    • Journal Title

      Autonomic Neuroscience : Basic and Clinical 119

      Pages: 48-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Low and high frequency acupuncture stimulation inhibits mental stress-induced sweating in humans via different mechanism.2005

    • Author(s)
      Akihiro Ogata
    • Journal Title

      Auton Neurosci 118・1-2

      Pages: 93-101

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of body posture on local sweating and sudomotor outflow as estimated using sweat expulsion.2005

    • Author(s)
      Yoko Inukai
    • Journal Title

      Auton Neurosci 119・1

      Pages: 48-55

    • Related Report
      2005 Annual Research Report
  • [Journal Article] サーモグラフを用いた温熱性発汗部における単一汗腺活動の観察法2005

    • Author(s)
      西山 哲成
    • Journal Title

      Biomedical Thermology 24・2

      Pages: 34-38

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 発汗反応の性差:QSARTによる末梢性機序の検討2005

    • Author(s)
      松本 孝朗
    • Journal Title

      発汗学 12・1

      Pages: 42-44

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 温熱性発汗の調節機構2005

    • Author(s)
      菅屋 潤壹
    • Journal Title

      発汗学 13・1

      Pages: 18-24

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 日常的な運動習慣のない若年女性における発汗能の季節変動2005

    • Author(s)
      谷口 裕美子
    • Journal Title

      発汗学 13・1

      Pages: 25-27

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Low and high frequency acupuncture stimulation inhibits mental stress-induced sweating in humans via different mechanisms.2005

    • Author(s)
      Ogata A
    • Journal Title

      Autonomic Neuroscience 118・1-2

      Pages: 93-101

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of body posture on local sweating and sudomotor outflow, as estimated using sweat expulsion.2005

    • Author(s)
      Inukai Y
    • Journal Title

      Autonomic Neuroscience (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] サーモグラフ法を用いた温熱性発汗部における単一汗腺活動の観察法2005

    • Author(s)
      西山哲成
    • Journal Title

      Biomedical Thermology 24・2

      Pages: 34-38

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 暑熱馴化における発汗能増大の機序-発汗波頻度による中枢対末梢機序の寄与度-2004

    • Author(s)
      西村 直記
    • Journal Title

      発汗学 11

      Pages: 27-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 低頻度および高頻度の鍼通電刺激は異なった機序により精神性発汗を抑制する-発汗波頻度を指標にした分析2004

    • Author(s)
      緒方 昭広
    • Journal Title

      自律神経 41

      Pages: 491-494

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of CO_2-bath (100ppm) immersion on thermoregulatory responses in human.2004

    • Author(s)
      Sato M
    • Journal Title

      Journal of Thermal Biology 29・7-8

      Pages: 805-808

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 低頻度および高頻度の鍼通電刺激は異なった機序により精神性発汗を抑制する-発汗波頻度を指標にした分析-2004

    • Author(s)
      緒方昭広
    • Journal Title

      自律神経 41・5

      Pages: 491-494

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 皮膚圧迫は発汗神経を介して皮膚血流を減少させる?-皮膚圧迫が皮膚血流に及ぼす効果の皮膚交感神経活動を用いた検討-2004

    • Author(s)
      菅屋潤壹
    • Journal Title

      発汗学 11

      Pages: 18-20

    • Related Report
      2004 Annual Research Report
  • [Book] 本間研一, 彼末一之(編)環境生理学(担当:暑熱適応)2007

    • Author(s)
      菅屋 潤壹
    • Publisher
      北海道大学出版会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 環境生理学(本間研一・彼末一之 : 編) 暑熱適応(分担執筆)2007

    • Author(s)
      菅屋潤壹
    • Publisher
      北海道大学出版会
    • Related Report
      2006 Annual Research Report
  • [Book] 自律神経の基礎と臨床(改訂3版,後藤由夫・本郷道夫 : 編)発汗の病態と検査法(分担執筆)2006

    • Author(s)
      菅屋潤壹
    • Publisher
      医薬ジャーナル社
    • Related Report
      2006 Annual Research Report
  • [Book] Temperature regulation. In : Primer on the Autonomic Nervous System. ((eds.) Robertson D, Biaggioni I, Burnstock G, Low PA.)2004

    • Author(s)
      Kihara M
    • Publisher
      Elsevier Academic Press, (San Diego)
    • Related Report
      2004 Annual Research Report
  • [Book] 発汗の病態と検査法.自律神経の基礎と臨床 改訂3版

    • Author(s)
      菅屋 潤壹
    • Publisher
      医薬ジャーナル社(大阪)(印刷中)
    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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