| Project/Area Number |
16590274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
NAGASAKA Tetsuro Nagoya University, Graduate School of medicine, Associate Professor, 大学院・医学系研究科, 助教授 (40262894)
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Seiji Nagoya University, Graduate School of medicine, Associate Professor, 大学院・医学系研究科, 助教授 (20242860)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Aminopeptidases / P-LAP / Pancreatic islet / GLUT4 / VEGF receptor / Angiotensin II receptor / Uterine sarcoma / Ovarian cancer / 免疫組織化学染色 / 子宮内膜癌 / 前立腺癌 / 尿細管 |
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| Research Abstract |
In order to clarify the tissue distribution of membrane aminopeptidases and their roles for the tumor progression, immunohistchemical studies using antibodies for each aminopeptidases were done. Membrane aminopeptidases studied in this project were CD10, CD13, CD26, APA, P-LAP and A-LAP. New findings in this project were as follows ; P-LAP was locateded in human pancreatic islets and its distribution was closely associated with GLUT4 vesicles. A-LAP was located in human endometrial glands especially in the secretory vesicles like P-LAP. The distribution of A-LAP during menstral cycle is closely related with P-LAP. In the gynecological tumor, expression of P-LAP in endometrial carcinoma tissue is associated with poor outcome. Expression of VEGF and VEGF receptor in uterine sarcoma were associated with their prognosis. Expression of Angiotensin II type1 receptor were associated with tumor angiogenesis and prognosis in ovarian cancer.
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