• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of non-receptor tyrosine kinase Fyn in neurodegeneration of prion diseases

Research Project

Project/Area Number 16590302
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionTohoku University

Principal Investigator

MURAMOTO Tamaki  Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (40302096)

Co-Investigator(Kenkyū-buntansha) YAGI Takeshi  Osaka University, Graduate School of Frontier Biosciences, Professor, 大学院・生命科学研究科, 教授 (10241241)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordstyrosine kinase / fyn / knock-out / prion disease / neurodegeneration
Research Abstract

In order to explore the role of non-receptor tyrosine kinase Fyn in neurodegeneration of prion diseases, experimental prion diseases in mice homo- and hemi-zygotic for fyn-knockout allele were analyzed and compared with that in wild type mice. The diseases had indistinguishable incubation periods and shared all typical findings including clinical manifestations, spongiform degeneration and accumulation of protease-resistant prion protein in the brain tissue irrespective of mouse genotype. The deficiency of this single Src family tyrosine kinase seems not to affect prion pathogenesis.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi