Molecular epidemiology of hepatitis E virus in Japan and study on animal host of virus.
| Project/Area Number |
16590331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ABE Kenji National Institute of Infectious Diseases, Department of Pathology, Senior Research Scientist, 感染病理部, 主任研究官 (60130415)
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| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Hepatitis E / HEV / Animal host / International study / 国際研究 |
|---|
| Research Abstract |
I conducted seroepidemiological studies on antibody prevalence to hepatitis E virus (HEV) in 5,233 sera from 11 countries to ascertain the present state of HEV infection on a global basis. The rate of anti-HEV IgG positivity was as follows : 8.9% in Tokyo and 34.5% in Okinawa of Japan, 62.1% in Hanoi and 41.8% in Ho Chi Minh City of Vietnam, 29.2% in Harbin of China, 27% in Thailand, 35.1% in Myanmar, 66% in Nepal, 21.3% in U.S.A., 34% in Spain, 20.2% in Russia, 80% in Egypt and 12.7% in Bolivia, respectively. The prevalence of anti-HEV IgG increased with age in these tested countries, but the rate of antibody positivity was over 20% in the 16-30 year-old group in most of the participating countries, except for Japan, the U.S.A and Spain. Of patients with acute hepatitis of unknown etiology from Nepal, 56% (14/25) were positive for the IgM class of anti-HEV antibody. In addition, HEV RNAs in the serum from 3 Nepali patients who had the IgM antibody were detected by nested PCR and all of the HEV genes isolated belonged to genotype, 1. Our results indicate that HEV is spreading worldwide not only in developing countries, but also in more industrialized countries than previously thought.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Characteristic of hepatitis B virus in Ghana: Full length genome sequences indicates the endemicity of genotype E in West Africa.2006
Author(s)
Tran TT Huy, Koichi Ishikawa, William Ampofo, Taku Izumi, Akira Nakajima, Justina Ansah, John O.Tetteh, Nicholas Nii-Trebi, Simeon Aidoo, David Ofori-Adjei, Tetsutaro Sata, Hiroshi Ushijima, Kenji Abe
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Journal Title
Journal of Medical Virology 78
Pages: 178-184
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] International collaborative survey on epidemiology of hepatitis E virus in 11 countries.
Author(s)
Kenii Abe, Xin Ding, Tian-Cheng Li, Naokazu Takeda, Khin Maung Win, Pradeep Krishna Shrestha, Vo Xuan Quang, Trinh Thi Ngoc, Teresa Casanovas Taltavull, Andrei V.Smirnov, Vasily F.Uchaikin, Pairoj Luengrojanakul, Hongxi Gu, Abdel Rahman El-Zayadi, Alfred M.Prince, Naohiko Masaki, Kaoru Kikuchi, Tetsutaro Sata
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Journal Title
Southeast Asian Journal of Tropical Medicine and Public Health (in press)
Description
「研究成果報告書概要(欧文)」より
Related Report
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