• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Physiological role of IL-18 on induction of regulatory lymphocyte generation in Plasmodium infected mice.

Research Project

Project/Area Number 16590349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionHyogo College of Medicine

Principal Investigator

KASHIWAMURA Shin-ichiro  Hyogo College of Medicine, Faculty of Medicine, Assistant Professor, 医学部, 講師 (00185761)

Co-Investigator(Kenkyū-buntansha) OKAMURA Haruki  Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (60111043)
UEDA Haruyasu  Hyogo College of Medicine, Faculty of Medicine, Assistant Professor, 医学部, 講師 (10330458)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsIL-18 / Infection / Inflammation / IL-12 / TNF-α / Prostaglandin / Tissue injury / Wound heeling
Research Abstract

IL-18 plays important roles throughout immune reactions. We had revealed that, IL-18 deficient mice deteriorated pathogenesis of Plasmodium infection and exogenious IL-18 improved the disease (Shin R.P., Kashiwamura S. et al., J.Immunol.,2002). Further we had reported IL-18 could induced IL-4, IL-10 and IL-13 productions from T cells, NK cells and Mast cells (Kashiwamura S. et al., J.Immunothera.,2002). Moreover, we had reported IL-18 production in patients of endometoriosis and non-immune parenchymal cells produced PGE2 in response to IL-18 stimulation (Oku H., Tsuji Y., Kashiwamura S. et al., Hum Reprod., 2004).
In current study, we had revealed that IL-18 could prevent pathological changes in bleomycine-induced lung injury and caerulein-induced acute pancreatitis (Nakatani-Okuda A., Ueda H., Kashiwamura S. et al., Am.J. Physiol.Lung.Cell Mol. Physiol., 2005) (Ueno N., Kashiwamura S. et al., Shock, 2005). Our data strongly suggested the possibility that, NO or PGE2 induced by IL-18 suppress TNF-α production both in infectious disease and autoimmune diseases (Okamura H., Kashiwamura S., Ueda H., Nippon Rinsho, 2005).Further, we had revealed stress induced super-oxide induced IL-18 production through activation of Caspase-1 (Sekiyama A., Ueda H., Kashiwamura S. et al., Immunity, 2005)

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (29 results)

All 2006 2005 2004

All Journal Article (29 results)

  • [Journal Article] Chylomicron remnants stimulate release of interleukin-1beta by THP-1 cells.2006

    • Author(s)
      Okumura T., et al.
    • Journal Title

      J. Atheroscler. Thromb. 13・1

      Pages: 38-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A role of the adrenal gland in stress-induced up-reglation of cytokines in plasma.2006

    • Author(s)
      Sekiyama A., et al.
    • Journal Title

      J. Neuroimmunol. 171・1

      Pages: 38-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Production of IL-13 in spleen cells by IL-18 and Il-12 through generation of NK-like cells.2006

    • Author(s)
      Ueda H., et al.
    • Journal Title

      Cytokine 33・4

      Pages: 179-187

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Production of IL-13 in spleen cells by IL-18 and IL-12 through generation of NK-like cells.2006

    • Author(s)
      Ueda H.et al.
    • Journal Title

      Cytokine vol.33,No.4

      Pages: 179-187

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chylomicron remnants stimulate release of interleukin-1beta by THP-1 cells.2006

    • Author(s)
      Okumura T., et al.
    • Journal Title

      J.Atheroscler.Thromb. 13・1

      Pages: 38-45

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A role of the adrenal gland in stress-induced up-reglation of cytokines in plasma.2006

    • Author(s)
      Sekiyama A., et al.
    • Journal Title

      J.Neuroimmunol. 171・1

      Pages: 38-44

    • Related Report
      2005 Annual Research Report
  • [Journal Article] IL-18; a cytokine translates a stress into medical science.2005

    • Author(s)
      Sekiyama A., et al.
    • Journal Title

      J. Med. Invest. 52・Suppl.

      Pages: 236-239

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of interleukin 18 in nitric oxide production and pancreatic damage during acute pancreatitis.2005

    • Author(s)
      Ueno N., et al.
    • Journal Title

      Shock 24・6

      Pages: 564-570

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Plasma interleukin-18 concentration : a novel marker of myocardial ischemia rather than necrosis in humans.2005

    • Author(s)
      Kawasaki D., et al.
    • Journal Title

      Coron Artery Dis. 16・7

      Pages: 437-441

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Selective granulocyte and monocyte apheresis as a new adjunct to enhance the efficacy of interferon-alpha+ribavirin in patients with high plasma hepatitis C virus.2005

    • Author(s)
      Sawada K., et al.
    • Journal Title

      Dig. Liver Dis. 37・7

      Pages: 515-521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A stress-induced, superoxide-mediated caspase-1 activation pathway causes plasma IL-18 upregulation.2005

    • Author(s)
      Sekiyama A., et al.
    • Journal Title

      Immunity 22・6

      Pages: 669-677

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Interleukin-18 in pathogenesis of rheumatoid arthritis.2005

    • Author(s)
      Okamura H., et al.
    • Journal Title

      Nippon Rinsho 63・Suppl-1

      Pages: 175-180

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Protection against bleomycin-induced lung injury by IL-18 in mice.2005

    • Author(s)
      Nakatani-Okuda A., et al.
    • Journal Title

      Am. J. Physiol. Lung Cell Mol. Physiol. 289・2

      Pages: 280-287

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nonredandant roles of Sema4A in the immune system : defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.2005

    • Author(s)
      Kumanogoh A., et al.
    • Journal Title

      Immunity 22・3

      Pages: 305-316

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Chylomicron rermmnants stimulate release of interleukin-1 beta by THP-1 cells2005

    • Author(s)
      Okumura T.et al.
    • Journal Title

      J.Atheroscler.Thromb vol.13,No.1

      Pages: 3-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IL-18 ; a cytokine translatea a stress into medical science.2005

    • Author(s)
      Sekiyama A.et al.
    • Journal Title

      J.Medical Investigation vol.52. Suppl.

      Pages: 236-239

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of interleukin-18 in nitric oxide production and pancreatic damage during acute pancreatitis.2005

    • Author(s)
      Ueno N.et al.
    • Journal Title

      Shock vol.24,No.6

      Pages: 564-570

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A role of the adrenal gland in stress-induced up-regulation of cytokines in plasma.2005

    • Author(s)
      Sekiyama A.et al.
    • Journal Title

      J.Neuroimmunology vol.171,No.1

      Pages: 38-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Plasma interleukin-18 concentration : a novel marker of myocardial ischemia rather than necrosis in humans.2005

    • Author(s)
      Kawasaki D.et al.
    • Journal Title

      Coron.Artery Dis. vol.16,No.7

      Pages: 437-441

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Selective glanurocyte and monocyte apheresis as a new adjunct to enhance the efficacy of interferon-alpha + rivabirin in patients with high plasma hepatits C virus.2005

    • Author(s)
      Sawada.K.et al.
    • Journal Title

      Dig.Liver Dis. vol.37,No.7

      Pages: 515-521

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A stress-induced, superoxide-mediated caspase-1 activation pathway causes plasma IL-18 upregulation2005

    • Author(s)
      Sekiyama A.et al.
    • Journal Title

      Immunity vol.22, No.6

      Pages: 669-677

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Interleukin-18 in pathogenesis of rheumatoid arthritis.2005

    • Author(s)
      Okamura H.et al.
    • Journal Title

      Nippon Rinsho vol.63,Suppl-1

      Pages: 175-180

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protection against bleomycin -induced lung injury by IL-18 in mice2005

    • Author(s)
      Nakatani-Okuda A.et al.
    • Journal Title

      Am.J.Physiol.Lung Cell Mol.Physiol. vol 289,No.2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nonredundant roles of Sema4 in the immune system : defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.2005

    • Author(s)
      Kumanogo A.et al.
    • Journal Title

      Immunity vol.22,No.3

      Pages: 305-316

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] IL-18 ; a cytokine translates a stress into medical science.2005

    • Author(s)
      Sekiyama A., et al.
    • Journal Title

      J.Med.Invest. 52・Suppl.

      Pages: 236-239

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Selective granulocyte and monocyte apheresis as a new adjunct to enhance the efficacy of interferon-alpha+ribavirin in patients with high plasma hepatitis C virus.2005

    • Author(s)
      Sawada K., et al.
    • Journal Title

      Dig.Liver Dis. 37・7

      Pages: 515-521

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Protection against bleomycin-induced lung injury by IL-18 in mice.2005

    • Author(s)
      Nakatani-Okuda A., et al.
    • Journal Title

      Am.J.Physiol.Lung Cell Mol.Physiol. 289・2

      Pages: 280-287

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of IL-18 in pathogenesis of endometriosis.2004

    • Author(s)
      Oku H., et al.
    • Journal Title

      Human Reproduction 19・3

      Pages: 709-714

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Inhibition by IL-18 of the growth of Dunn osteosarcoma Cells.2004

    • Author(s)
      Okamoto T., et al.
    • Journal Title

      Journal of Interferon Cytokine Research 24・3

      Pages: 161-167

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi