| Project/Area Number |
16590436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Oita University (2005)
Hamamatsu University School of Medicine (2004) |
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Principal Investigator |
OHASHI Kyoichi Oita University, Faculty of Medicine, professor, 医学部, 教授 (20137714)
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| Co-Investigator(Kenkyū-buntansha) |
EGUCHI Kenji Tokai University, Faculty of Medicine, professor, 医学部, 教授 (30349336)
HYODO Ichinosuke University of Tsukuba, Graduate school, professor, 大学院, 教授 (60416469)
UCHIDA Shinya University of Shizuoka, School of Pharmaceutical Science, assistant professor, 薬学部, 講師 (80372522)
KOTEGAWA Tsutomu Oita University, Faculty of Medicine, assistant professor, 医学部, 助教授 (20264343)
橋本 久邦 国立大学法人浜松医科大学, 医学部附属病院, 教授 (10009558)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | morphine / pharmacogenetics / opioid receptor / UGT2B7 |
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| Research Abstract |
Morphine is the most important and widely used opioid analgesics. The interindividual differences in its pharmacokinetics and in its adverse effects are major limitations for individualized pain treatment. We have observed a wider interindividual difference in plasma M3G/morphine ratio after both oral and intravenous administration of morphine. However, we did not observed a pharmacogenetic effect of UGT2B7. The human μ-opioid receptor, which is coded by the OPRM1 gene is a primary candidate for the clinical outcome. Several candidate gene analysis in 12 cancer patients were performed during morphine therapy. The adverse effects of morphine, drowsiness or confusion, was observed frequently in homozygous carriers of the mutated G118 allele of OPRM1.
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