| Project/Area Number |
16590448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NARA Nobuo Tokyo Medical and Dental University, Postgraduate School, Professor, 大学院・医歯学総合研究科, 教授 (00142258)
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| Co-Investigator(Kenkyū-buntansha) |
TOHDA Shuji Tokyo Medical and Dental University, Postgraduate School, Associate Professor, 大学院・医歯学総合研究科, 助教授 (80251510)
MURAKAMI Naomi Tokyo Medical and Dental University, Department of Medicine, Assistant, 医学部附属病院, 助手 (50143582)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Leukemia / Molecular-Targeting Therapy / Notch Ligand / Leukemia Cell Line |
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| Research Abstract |
1. System Detecting the Effect of Molecular-Targeting Therapy for Leukemia.
We have established leukemia cells lines that proliferate autonomously producing granulocyte-colony-stimulating factor (G-CSF) or granulocyte-macrophage-colony-stimulating factor (GM-CSF). Using these cell lines, we have examined the effects of antileukemic drugs and molecular-targeting drugs, imatinib and all-trans retinoic acid.
2. Study on the Effect of Notch-ligands on Leukemia Cells.
Notch-ligands have been shown to activate the self-renewal of stem cells. We have studied on the effects of some Notch-ligands on the leukemia cells from established cell lines and the cell obtained from the freshly diagnosed patient. Notch-ligands showed various effect on leukemia cells. In some cases Notch-ligands have been shown to be involved in the leukemia growth.
3. Relationship between the in vitro Effect of Antileukemic Therapy on Leukemia Cells and the Patients Prognosis.
After studying the effect on leukemia cells growth in vitro, we have followed the prognosis of the patients to determine the relationship between the in vitro effect and clinical effectiveness.
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