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Evaluation of intravascular hemolysis with erythrocyte creatine

Research Project

Project/Area Number 16590460
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKochi University

Principal Investigator

SUGIURA Tetsuro  Kochi Medical School, Professor, 医学部, 教授 (50171145)

Co-Investigator(Kenkyū-buntansha) OKUMIYA Toshika  Kumamoto University, Associate professor, 医学部, 助教授 (50284435)
SAIBARA Toshiji  Kochi Medical School, Associate professor, 医学部, 助教授 (60145125)
MATSUBARA Yoshihisa  Kochi Medical School, Assistant professor, 医学部, 助手 (10274391)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsErythrocyte creatine / Erythrocyte age / Intravascular hemolysis / Cardiac valve prostheses / Peak flow velocity / Valve regurgitation
Research Abstract

Intracardiac high-velocity jets through stenosed or incompetent orifices can cause intravascular hemolysis. Intravascular hemolysis has been identified in patients with prosthetic heart valves and in patients with native valvular heart disease. Erythrocyte creatine is regarded as a sensitive and quantitative marker of mean age of the erythrocytes, because creatine contents in erythrocytes decrease gradually with advancing cell age and an increase in erythrocyte creatine quantitatively reflects the degree of shortened erythrocyte survival. To detect intravascular hemolysis in patients with cardiac valve prostheses and aortic stenosis, erythrocyte creatine was evaluated with other hemolytic markers and hemodynamic parameters.
In patients with prosthetic heart valves, those with high erythrocyte creatine levels (>1.8μmol/g hemoglobin) exhibited significantly higher total peak flow velocity than those with normal erythrocyte creatine levels (p=0.006). Erythrocyte creatine had a significant correlation with total peak flow velocity (r=0.64,p<0.001). Patients with high LDH levels (>460IU/L) showed significantly higher myoglobin (p=0.008) and myosin light chain 1 (p=0.02) than those with normal LDH levels, whereas erythrocyte creatine was not related to cardiac muscle markers.
In patients with aortic stenosis, patients with aortic stenosis had a significantly higher erythrocyte creatine as compared with the controls (p<0.001). Patients with aortic stenosis had significantly lower erythrocyte count, hemoglobin and hematocrit than those in controls. Fourteen of 16 patients with aortic stenosis had peak flow velocity >50mmHg and erythrocyte creatine had a good correlation with peak flow velocity (r=0.72,p<0.001).
Conclusion : Erythrocyte creatine is a reliable marker to estimate the severity of intravascular hemolysis in patients with prosthetic heart valve and aortic stenosis.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (3 results)

All 2004

All Journal Article (3 results)

  • [Journal Article] Evaluation of intravascular hemolysis with erythrocyte creatine in patients with cardiac valve protheses.2004

    • Author(s)
      Okumiya T, Nishi M, Doi T, Kamioka M, Takeuchi H, Doi Y, Sugiura T
    • Journal Title

      Chest 125・6

      Pages: 2115-2120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evaluation of intravascular hemolysis with erythrocyte creatine in patients with cardiac valve prostheses.2004

    • Author(s)
      Okumiya T, Nishi M, Doi T, Kamioka M, Takeuchi H, Doi Y, Sugiura T.
    • Journal Title

      Chest 125

      Pages: 2115-2120

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evaluation of intravascular hemolysis with erythrocyte creatine in patients with cardiac valve prostheses2004

    • Author(s)
      Okumiya T, et al.
    • Journal Title

      Chest 125

      Pages: 2115-2120

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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