| Co-Investigator(Kenkyū-buntansha) |
MINE Mariko Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (00108292)
SHIBATA Yoshisada Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (40010954)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
The objective of the present study was to investigate secular trends of health examination data in atomic bomb survivors.
1. Longitudinal Study of Bone Mineral Density among Postmenopausal Women
A total of 195 community-dwelling women, aged from 50 to 69 years, underwent a baseline survey between May 1994 and April 1995. The bone mineral density (BMD) of anterior-posterior lumbar spine (L2-L4) was measured by dual-energy X-ray absorptiometry. We measured BMD repeatedly until April 2004. The mean number of measurements for each subject was 3.1 times and the mean length of follow-up was 5.4 years. A significant reduction in BMD was observed in those who were aged 50-54 years at the baseline (from 0.862 to 0.814) and in those who were aged 55-59 (from 0.807 to 0.791), while BMD did not change significantly in those who were aged 60-69. Linear regression analysis confirmed that BMD reduced quadratically with age, however years since menopause, BMI and lifestyle factors did not have significant impact on the reduction in BMD.
2. Secular Trends of Health Examination Data in Atomic Bomb Survivors Who Died from Leukemia, Lymphoma and Myeloma
The study subjects were 502 atomic bomb survivors who died from leukemia, lymphoma and myeloma (acute leukemia 94, chronic leukemia 86, other types of leukemia 50, lymphoma 63, myeloma 70, and others 139). Secular trends of white blood cell (WBC) counts, serum uric acid, lactate dehydrase and C-reactive protein were analyzed by using longitudinal data analysis methods. Disease specific longitudinal pattern of health examination data were identified. The WBC counts were decreasing with approaching toward the death in the acute leukemia patients, while the WBC counts were increasing in the chronic leukemia patients. In patients of lymphoma or meyloma, the WBC counts fluctuated within a range of 2,000 to 10,000 (/μL).
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