• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Significance of microcirculatory disturbance of basilar ventricular septum in cases of sudden cardiac death

Research Project

Project/Area Number 16590533
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionAkita University

Principal Investigator

NISHIDA Naoki  Akita University, School of Medicine, Associate Professor, 医学部, 助教授 (10315088)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsSudden cardiac death / Myocardial ischemia / Ventricular septum / Morphometry / Cardiac conduction system / Immunohistochemistry
Research Abstract

1. Author examined 60 heart of sudden cardiac death and compared with 20 normal hearts. Possible significant decreasing of small arteries and endothelial cells were found in basilar ventricular septum in some cases of sudden cardiac death. This results showed localized ischemia in basilar ventricular septum due to relative decreasing of small arteries and capillaries in basilar may be one of the causes of sudden cardiac death.
2. The cardiac conduction system of 80 hearts without gross injury from patients who had received cardiopulmonary resuscitation (CPR) due to non-traumatic causes was examined. Of these 80 cases, localized hemorrhage and injury without inflammatory reaction was evident in 7 of these cases. It can be presumed that injuries to the conduction system do occur in limited regions during CPR.
3. We present two extremely rare autopsy cases with atresia of the left coronary ostium. Case 1 was a 34-year-old man who died of sudden cardiac death and Case 2 was an 82-year-old woman who died from non-cardiac causes. In both cases, a string-like small left main trunk that was located in its normal position was found, however the orifice of the left coronary artery was absent. The caliber and/or other anatomical features of the Collateral artery may predominantly dictate the clinical course of patients with atresia of the left coronary ostium.
4. We report a case of sudden unexpected death in a 17-year-old male student showing similar clinical background and pathological findings to Reye's syndrome. His heart showed some cardiac abnormal findings and did not showed any findings of Reye's syndrome. The present case would seem to suggest that a postmortem diagnosis of RS should be determined very carefully in cases of sudden death, even if the general circumstances would seem to be consistent with RS.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (9 results)

All 2006 2005

All Journal Article (9 results)

  • [Journal Article] Relationship between cardiopulmonary resuscitation and injuries of the cardiac conduction system : pathological features and pathogenesis of such injuries.2006

    • Author(s)
      Nishida N. et al.
    • Journal Title

      Crit Care Med 34・2

      Pages: 363-367

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relationship between cardiopulmonary resuscitation and injuries of the cardiac conduction system : Pathological features and pathogenesis of such injuries2006

    • Author(s)
      Nishida N, et al.
    • Journal Title

      Crit Care Med. 34(2)

      Pages: 363-367

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relationship between cardiopulmonary resuscitation and injuries of the cardiac conduction system : Pathological features and pathogenesis of such injuries.2006

    • Author(s)
      Nishida N et al.
    • Journal Title

      Crit Care Med 34・2

      Pages: 363-367

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Two adult cases of congenital atresia of the left coronary ostium - Comparison of a sudden death case with a long-term survival case.2005

    • Author(s)
      Nishida N. et al.
    • Journal Title

      Virchow Archiv 447・10

      Pages: 742-746

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sudden unexpected death of a 17-year-old male infected with influenza virus.2005

    • Author(s)
      Nishida N. et al.
    • Journal Title

      Legal Med 7・1

      Pages: 51-57

    • NAID

      10027260638

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two adult cases of congenital atresia of the left coronary ostium - Comparison of a sudden death case with a long-term survival case.2005

    • Author(s)
      Nishida N, et al.
    • Journal Title

      Virchow Archiv 447(10)

      Pages: 742-746

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sudden unexpected death of a 17-year-old male infected with influenza virus.2005

    • Author(s)
      Nishida N. et al.
    • Journal Title

      Legal Med 7(1)

      Pages: 51-57

    • NAID

      10027260638

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Two adult cases of congenital atresia of the left coronary ostium - Comparison of a sudden death case with a long-term survival case.2005

    • Author(s)
      Nishida N et al.
    • Journal Title

      Virchow Arch 447・10

      Pages: 742-746

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sudden unexpected death of a 17-year-old male infected with influenza virus.2005

    • Author(s)
      Nishida N et al.
    • Journal Title

      Legal Med 7・1

      Pages: 51-57

    • NAID

      10027260638

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi