• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of Chronic Ethanol Administration on Disposition of Ethanol and its Metabolites and Drug-interaction

Research Project

Project/Area Number 16590540
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionYamaguchi University

Principal Investigator

FUJIMIYA Tatsuya  Yamaguchi University, Faculty of Medicine, Professor, 医学部, 教授 (50219044)

Co-Investigator(Kenkyū-buntansha) LIU Jinyao  Yamaguchi University, Faculty of Medicine, Research Associate, 医学部, 助手 (60379956)
SHIMAMOTO Akiko  Yamaguchi University, Faculty of Medicine, Research Associate, 医学部, 助手 (10379943)
KOZAWA Shuji  Yamaguchi University, Faculty of Medicine, Research Associate, 医学部, 助手 (20379944)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsAlcohol / Acetaldehyde / Acetate / Chronic alcohol intoxication / Pharmacokinetics / Alcohol Metabolism / Toxicokinetics / Ethanol / 薬物相互作用
Research Abstract

Acetaldehyde and acetate (AcT) are the first and second metabolites of ethanol and detected in the plasma. Acetaldehyde and acetate redistribution from hepatic to peripheral tissues was reported during ethanol metabolism. Chronic ethanol administration affects ethanol metabolism. However, the effects of chronic ethanol intoxication on the disposition of its metabolites were hardly examined. In this study, we conducted the pharmacokinetic studies on the effects on its metabolites. Seven - weeks old, male Wister rats fed a nutritionally adequate liquid-diet in which ethanol was provided by 21% (3g/dl) or 35% (5g/dl) of the total calories. These diets were originally formulated by Lieber and DeCarli. At the beginning of the study, all rats were given the control liquid-diet for 4 days. For the next 4 days, the rats were fed either the control liquid-diet or 3g/dl ethanol liquid-diet. The 3g/dl group received this ethanol concentration for 45 days, while the 5g/dl group received a diet containing 4g/dl of ethanol for the next 3 days, followed by 5g/dl diet for 42 days. To maintain a similar caloric intake among the groups, the groups were pair-fed. Liquid-diet consumption was adjusted daily according to the animal's body weight and the daily liquid-diet intake. A bolus of EtOH saline solution (0.5,1.0,2.0 g/kg) was injected intravenously. Blood EtOH and AcT concentrations were measured by using head-space gas chromatography. The elimination rate of ethanol and the steady-state concentration of acetate increased with chronic ethanol exposure.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (12 results)

All 2006 2005

All Journal Article (12 results)

  • [Journal Article] ラットにおけるアルコール代謝の加速度的増強と代謝産物の血中動態変化2006

    • Author(s)
      小澤周二 他
    • Journal Title

      日本法医学雑誌 60.1

      Pages: 76-76

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determination of Endogenous Testosterone in Rat Tissues Following Fetal Alcohol Exposure Using HPLC with UV Detection2006

    • Author(s)
      Shimamoto, A. et al.
    • Journal Title

      Journal of Chromatography 836.1-2

      Pages: 69-73

    • NAID

      10025783724

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pharmacokinetic Study of Ethanol and its Metabolites in Swift Increase in Alcohol Metabolism (SIAM)2006

    • Author(s)
      Kozawa, S., et al.
    • Journal Title

      The Japanese Journal of Legal Medicine vol.60(1)

      Pages: 76-76

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determination of Endogenous Testosterone in Rat Tissues Following Fetal Alcohol Exposure Using HPLC with UV Detection2006

    • Author(s)
      Shimamoto, A., et al.
    • Journal Title

      Journal of Chromatography vol.836(1-2)

      Pages: 69-73

    • NAID

      10025783724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Determination of endogenous testosterone in rat tissues following fetal alcohol exposure using HPLC with UV detection2006

    • Author(s)
      A.Shimamoto et al.
    • Journal Title

      Journal of Chromatography (発行予定)

    • NAID

      10025783724

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アルコール点滴静注時のアルコールと代謝産物の血中動態に関する研究-アルコール消失速度と血中酸濃度との関係-2005

    • Author(s)
      嶋本晶子 他
    • Journal Title

      アルコールと医学生物学 25

      Pages: 144-147

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 飲酒と心臓突然死 第1報 : 飲酒パターンと心機能障害2005

    • Author(s)
      劉 金耀 他
    • Journal Title

      日本アルコール・薬物医学雑誌 40.4

      Pages: 386-387

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] アルコール代謝の加速的増強と代謝産物の血中動態変化-シアナマイドの影響-2005

    • Author(s)
      小澤周二 他
    • Journal Title

      日本アルコール・薬物医学雑誌 40.4

      Pages: 364-365

    • NAID

      10016687483

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pharmacokinetic Study of Ethanol its Metabolites during Ethanol Infusion : Alcohol Elimination Rate and Blood Concentration of Acetic Acid2005

    • Author(s)
      Shimamoto, A., et al.
    • Journal Title

      Alcohol and Biomedical Science vol.25

      Pages: 144-147

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Alcohol Consumption and Sudden Cardiac Death. Report 1 : Ethanol Consumption Pattern and Cardiac Dysfunction2005

    • Author(s)
      Liu, Jinyao., et al.
    • Journal Title

      Japanese Journal of Alcohol Studies & Drug Dependence vol.40(4)

      Pages: 386-387

    • NAID

      10016687497

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pharmacokinetic Study of Ethanol and its Metabolites in Swift Increase in Alcohol Metabolism (SIAM) --Effect of cyanamide--2005

    • Author(s)
      Kozawa, S., et al.
    • Journal Title

      Japanese Journal of Alcohol Studies & Drug Dependence vol.40(4)

      Pages: 364-365

    • NAID

      10016687483

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] アルコール点滴静注時のアルコールと代謝産物の血中動態に関する研究-アルコール消失速度と血中酢酸濃度の関係-2005

    • Author(s)
      嶋本, 晶子他
    • Journal Title

      アルコールと医学生物学 25

      Pages: 144-147

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi