Effect of Kampo medicine on cognition and behavior of Alzheimer's disease patinas.

• Project/Area Number: 16590554
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: ARAI Hiroyuki Tohoku University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (30261613)
• Co-Investigator(Kenkyū-buntansha): 岩崎 鋼 東北大学, 大学院・医学系研究科, 助教授
• Project Period (FY): 2004 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥3,800,000 (Direct Cost: ¥3,800,000); Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000); Fiscal Year 2004: ¥3,300,000 (Direct Cost: ¥3,300,000)
• Keywords: Alzheimer's disease / cognitive function / complementary and alternative medicine / Dementia with Lewy bodies / Kampo medicine / Integrated medicine / Donepezil / cerebral blood flow / 認知症 / 漢方薬 / ランダム化比較研究 / MMSE / Barthel Index / 痴呆症 / 二重盲験ランダム化比較試験

Research Abstract

In this study, we showed 3 major findings (evidenced based medicine) regarding complementary and alternative medicine of Kampo medicine
1.A combinatorial use of donepezil and kami-untan-to(Japanese herbal medicine) was found to be more beneficial than each drug alone. An increase in cerebral blood flow also was observed only in the patients who received both donepezil and kami-untan-to. These results may provide a new evidence for integrated medicine of Western/complementary and alternative medicine.
2.A randomized, placebo-controlled, double blind clinical trial showed that 8 week treatment by Ba-wei-di-huang wan, a traditional Chinese medicine, wan was found to improve not only cognitive function, but also physical activity in Alzheimer's patients. No serious adverse events were found following use of Ba-wei-di-huang.
3.No reliable therapy was known to be beneficial in dementia with Lewy bodies. A observer-blind controlled study showed that Yi-Gan-San, a traditional Chinese medicine, was found to be beneficial in reducing severity and frequency of behavioral and psychological symptoms of dementia such as visual hallucination, delusion and emotional irritability. Notably, it is most notable that visual hallucination associated with dementia with Lewy bodies declined dramatically without producing neuroleptic supersensitivity. Yi-Gan-San improve not only cognitive functions.

Research Products

• [Journal Article] Benefits of combining kami-untan-to, a Japanese herbal medicine, with donepezil in the treatment of Alzheimer' s disease. A observer-blind donepezil-menotherapy controlled trial. (2006)
  • Author(s): Iwasaki K, Maruyama M, Arai H. et al.
  • Journal Title: J. Am. Geriatr. Med. (In Press.)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer's amyloid beta proteins (2006)
  • Author(s): Fujiwara H, Iwasaki K, Furukawa K, Seki T, Mei H, Maruyama, M, Tomita N, Kudo Y, Higuchi M, Saido T, Maeda S, Takashima A, Hara Masahiko, Ohizumi Y, Arai H.
  • Journal Title: J. Neurosci. Res. (In Press.)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of a traditional Chinese herbal medicine for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in dementia with Kewy bodies. (2006)
  • Author(s): Iwasaki K, Arai H.
  • Journal Title: J. Clin. Psychiatry (In Press.)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A Randomized Observer-Blind Controlled Trial of a Traditional Chinise Mdeicine, Yi-Gan San, on Behaviroral and Psychological Symptoms and Activities of Daily Living in Dementia Patiensta. (2006)
  • Author(s): Iwasaki K, Sato-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H.
  • Journal Title: J.Clin.Psyciaty. 66 Pages: 248-252
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Benefits of combining kami-untan-to, a Japanese herbal medicine, with donepezil in the treatment of Alzheimer's disease. A observer-blind donepezil-menotherapy controlled trial. (2006)
  • Author(s): Iwasaki K, Maruyama M, Arai H, et al.
  • Journal Title: J.Am.Geriatr.Med. In press
• [Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer's amyloid beta proteins (2006)
  • Author(s): Fujiwara H, Iwasaki K, Furukawa K, Seki T, Mei H, Maruyama, M, Tomita N, Kudo Y, Higuchi M, Saido T, Maeda S, Takashima A, Hara Masahiko, Ohizumi Y, Arai H.
  • Journal Title: J.Neurosci.Res. In press
• [Journal Article] Combination of Western and Oriental medicine therapies for geriatric syndrome. (2005)
  • Author(s): Iwasaki K, Seki T, Arai H, Sasaki H.
  • Journal Title: Geriatr. Gerontol. Int. 5 Pages: 216-223
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The heterogeneity and natural history of mild cognitive impairment. (2005)
  • Author(s): Arai H, Maruyama M.
  • Journal Title: Arch. Neurol. 62 Pages: 163-164
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Acupuncture for dysphasia in poststroke patients : A videofluoroscopic study. (2005)
  • Author(s): Seki T, Iwasaki K, Arai H, Sasaki H, Hayashi H, Yamada S, Toba K.
  • Journal Title: J. Am. Geriatr. Soc. 53 Pages: 1083-1084
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Acupuncture for patients with glaucoma. (2005)
  • Author(s): Kurusu M, Watanabe K, Nakazawa T, Seki T, Arai H, Sasaki H, Fuse N, Tamai M.
  • Journal Title: Explore 1 Pages: 372-372
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A Randomized Observer-Blind Controlled Trial of a Traditional Chinise Mdeicine, Yi-Gan San, on Behaviroral and Psychological Symptoms and Activities of Daily Living in Dementia Patiensta. (2005)
  • Author(s): Iwasaki K, Sato-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H.
  • Journal Title: J. Clin. Psychiatry. 66 Pages: 248-252
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Combination of Western and Oriental medicine therapies for geriatric syndrome. (2005)
  • Author(s): Iwasaki K, Seki T, Arai H, Sasaki H.
  • Journal Title: Geriatr.Gerontol.Int. 5 Pages: 216-223
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The heterogeneity and natural history of mild cognitive impairment. (2005)
  • Author(s): Arai H, Maruyama M.
  • Journal Title: Arch.Neurol. 62 Pages: 163-164
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Acupuncture for dysphasia in poststroke patients : A videofluoroscopic study. (2005)
  • Author(s): Seki T, Iwasaki K, Arai H, Sasaki H, Hayashi H, Yamada S, Toba K.
  • Journal Title: J.Am.Geriatr.Soc. 53 Pages: 1083-1084
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The neural correlates of driving performance identified using positron emission tomography. (2005)
  • Author(s): Horikawa E, Okamura N, Tashiro M, Sakurada Y, Maruyama M, AraiH, Yamaguchi K, Sasaki H, Yanai K, Itoh M
  • Journal Title: Brain and Cognition (In Press)
• [Journal Article] A Randomized Observer-Blind Controlled Trial of a Traditional Chinese Medicine, Yi-Gan San, on Behavioral and Psychological Symptoms and Activities of Daily Living in Dementia Patients. (2005)
  • Author(s): Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H.
  • Journal Title: J.Clin.Psychiatry 248-252 Pages: 248-252
• [Journal Article] Caregiver's burden and use of public services among dementia caregivers. (2005)
  • Author(s): Tanji H, Ootsuki M, Matsui T, Maruyama M, Nemoto M, Tomita N, Seki T, Iwasaki K, Arai H, Sasaki H.
  • Journal Title: Geriatr.Gerontol.Internat. (In Press)
  • NAID: 10015522376
• [Journal Article] Postural sway and falls in Alzheimer's disease : A prospective study. (2005)
  • Author(s): Horikawa E, Matsui T, Arai H, Seki T, Iwasaki K, Sasaki H.
  • Journal Title: Intern.Med. (In press)
• [Journal Article] Cognitive impairment and diffuse white matter atrophy inalcoholics (2005)
  • Author(s): Mochizuki H, Masaki T, Matsushita S, Ugawa Y, Kamakura K, Arai H, Motoyoshi K, Higuchi S.
  • Journal Title: Clin.Neurophys 116 Pages: 223-228
• [Journal Article] Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease. (2005)
  • Author(s): Matsushita S, Arai H, et al.
  • Journal Title: J.Neural Transms (In press)
• [Journal Article] A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine Ba Wei Di Huang Wan in the treatment of dementia. (2004)
  • Author(s): Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Akiba T, Arai H, Cyong J-C, Sasaki H.
  • Journal Title: J.Am.Geriatr.Soc. 52 Pages: 1518-1521
• [Journal Article] Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. (2004)
  • Author(s): Okamura N, Suemoto T, Shimadzu H, Suzuki M, Shiomitsu T, Akatsu H, Yamamoto T, Staufenbiel M, Yanai K. Arai H, Sasaki H, Kudo Y, Sawada T.
  • Journal Title: J.Neuroscience 24 Pages: 2535-2541
• [Journal Article] A novel imaging probe for in vivo detection of neuritic and duffuse plaques in the brain. (2004)
  • Author(s): Okamura N, Suemoto T, Shiomitsu T, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Arai H, Sasaki H. Yanai K, Staufenbiel M, Kudo Y, Sawada T.
  • Journal Title: J.Mol.Neurosci 24 Pages: 247-256
• [Journal Article] Cerebrospinal fluid tau protein and periventricular white matter lesions in aging, stable and progressive mild cognitive impairment : Implications for two major pathways. (2004)
  • Author(s): Maruyama M, Matsui T, Tanji H, Memoto M, Tomita N, Ootsuki M, Arai H, Sasaki H.
  • Journal Title: Arch.Neurol. 61 Pages: 716-720
• [Journal Article] Angiotensin converting enzyme inhibitors and incidence of Alzheimer's disease in Japan. (2004)
  • Author(s): Ohrui T, Matsui T, Yamaya M, Arai H, Ebihara S.Maruyama M, Sasaki H.
  • Journal Title: J.Am.Geriatr.Soc. 52 Pages: 649-650
• [Journal Article] Acupuncture for gait disorders in the elderly. (2004)
  • Author(s): Seki T, Kurusu M, Arai H, Sasaki H.
  • Journal Title: J.Am.Geriatr.Soc. 52 Pages: 643-644
• [Journal Article] Effects of the Chinese herbal medicine "Ba Wei Di Huang Wan" in the reatment of dementia : A SPECT cerebral blood flow examination and a randomized, double-blind, placebo-controlled clinical trial for cognitive function and A (2004)
  • Author(s): Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Akiba T, Arai H, Cyong J-C, Sasaki H.
  • Journal Title: Geriatr.Gerontol.Internat. 4
• [Journal Article] Mild cognitive impairment-beyond controversies towards consensus : report of the international working group on Mild cognitive impairment. (2004)
  • Author(s): Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund L-O, Nordberg A, Backman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, De Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack A, Jorm A, Richie K, Van Dubin C, Visser P, Petersen RC.
  • Journal Title: J.Intern.Med. 256 Pages: 240-246
• [Journal Article] Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism : A case report. (2004)
  • Author(s): Kikuchi A, Takeda A, Fujihara K, Kimpara T, Shiga Y, Tanji H, Nagai M, Ichinose H, Urano F, Okamura N, Arai H, Itoyama Y.
  • Journal Title: Movement Disorders 19 Pages: 590-593
• [Journal Article] Effect of Kami-Untan-To on the impairment of leaning nd memory induced by thiamine-deficient feeding in mice. (2004)
  • Author(s): Nakagawasai O, Yamadera F, Iwasaki K, Arai H, Taniguchi R, Tan-no K, Sasaki H, Tadano T.
  • Journal Title: Neuroscience 125 Pages: 233-241
• [Journal Article] Effects of brain-penetrating ACE inhibitors on Alzheimer's disease progression. (2004)
  • Author(s): Ohrui T, Tomita N, Satoh-Nakagawa T, Matsui T, Maruyama M, Niwa K, Arai H, Sasaki H.
  • Journal Title: Neurology 63 Pages: 1324-1325
• [Journal Article] Increased plasma 8-isoprostane levels in hypertensive subjects : the Tsurugaya project (2004)
  • Author(s): Hozawa A, Ebihara S, et al
  • Journal Title: Hypertension Research 27 Pages: 557-561
• [Journal Article] Benefits of combining kami-untan-to, a Japanese herbal medicine, with donepezil in the treatment of Alzheimer's disease. A observer-blind donepezil-menotherapy controlled trial.
  • Author(s): Iwasaki K, Maruyama M, Arai H. et al.
  • Journal Title: J.Am.Geriatr.Med. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Uncaria rhynchophylla, a Chinese medicinal herb, has potent anti-aggregation effects on Alzheimer's amyloid beta proteins
  • Author(s): Fujiwara H, Iwasaki K, Furukawa K, Seki T, Mei H, Maruyama, M, Tomita N, Kudo Y, Higuchi M, Saido T, Maeda S, Takashima A, Hara Masahiko, Ohizumi Y, Arai H.
  • Journal Title: J.Neurosci.Res. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of a traditional Chinese herbal medicine for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in dementia with Kewy bodies.
  • Author(s): Iwasaki K, Arai H.
  • Journal Title: J.Clin.Psychiaty. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] 漢方薬によるアミロイド凝集抑制作用等に関する研究 (2004)
  • Inventor(s): 荒井啓行, 岩崎 鋼
  • Industrial Property Rights Holder: 荒井啓行, 岩崎 鋼
  • Filing Date: 2004-12-27
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 漢方薬によるアミロイド凝集抑制作用等に関する研究 (2004)
  • Inventor(s): 荒井啓行, 岩崎 鋼
  • Industrial Property Rights Holder: 荒井啓行, 岩崎 鋼
  • Filing Date: 2004-12-27