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Development of immunomodulatory leukocyteapheresis by extracorporeal circulation in IBD

Research Project

Project/Area Number 16590567
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionAsahikawa Medical College

Principal Investigator

ASHIDA Toshifumi  Asahikawa Medical College, School of Medicine, Lecturer (50261409)

Co-Investigator(Kenkyū-buntansha) JIRO Watari  Asahikawa Medical College, School of Medicine, Lecturer (10311531)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsulcerative colitis / Crohn's disease / Glucocorticoid / Glucocorticoid rereptor / IL-18 / Leukocyteapheresis / IBD / HGR / Glucocorticoid / Th1 / hGR
Research Abstract

In some proportions of the patients with inflammatory bowel disease, unresponsiveness to glucocorticoid, which is one of the major therapeutic drugs for the disease, are noted during the course. We have reported that the nonfunctional isoform of the intracytoplasmic glucocorticoid receptor, namely hGR beta was expressed in peripheral blood mononuclear cells in glucocorticoid-resistant patients with IBD. In this process, proinflammatory IL-7 and IL-18 may augments hGR beta mRNA synthesis. In this study, we purposed to clarify the mechanism of glucocorticoid resistance in lymphocytes by measuring the size of IL-18-receptor-bearing lymphocytes and hGR beta mRNA expression in these cells, as a marker for clinical refractoriness. Until now, we have found the serum IL-18 concentration and hGR beta mNRA expression was positively correlated. We could not see the correlation between populations of IL-18 receptor positive T lymphocyte and patients responsiveness to glucocoticoid, or hGR beta mRNA expression. Leukocyteapheresis using extracorporeal circulation by centrifugal cell separator, or leukocyte absorbing filters, which reduced the disease activity of IBD, did not alter the hGR beta expression. Further investigation to elucidate the mechanisms glucocorticoid unresponsive of T lymphocyte, especially to find the role of hGR beta inducing IL-18 should be performed

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (9 results)

All 2005 2004

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] 潰瘍性大腸炎に対する遠心分離法による白血球除去療法2005

    • Author(s)
      盧田知史, 前本篤男, 岡本耕太郎, 他
    • Journal Title

      日本アフェレシス学会雑誌 24

      Pages: 137-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 難治性潰瘍性大腸炎治療としての白血球除去療法2005

    • Author(s)
      蘆田知史, 岡本耕太郎, 前本篤男, 他
    • Journal Title

      胃と腸 40

      Pages: 1389-1393

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Centrifugal leukocyte apheresis in UC2005

    • Author(s)
      Toshifumi, Ashida., Atsuo, Maemoto., Kohtaro, Okamoto., et al
    • Journal Title

      J of the Japanese Apheresis Society 24

      Pages: 137-141

    • NAID

      110003161414

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Leukocyteapheresis as an alternative therapy for refractory ulcerative colitis patients2005

    • Author(s)
      Toshifumi, Ashida., Kohtaro, Okamoto., Atsuo, Maemoto., et al
    • Journal Title

      I to Cho 40

      Pages: 1389-1393

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Glucocorticoid treatment in UC2005

    • Author(s)
      Ashida T, Kohgo Y.
    • Journal Title

      Nippon Rinsho 63-5

      Pages: 827-830

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The role of Paneth cells and their antimicrobial peptides in innate host defense.2004

    • Author(s)
      Ayabe T, Ashida T, Kohgo Y, 他
    • Journal Title

      Trends Microbiol 12

      Pages: 394-398

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The role of Paneth cells and their antimicrobial peptides in innate host defense2004

    • Author(s)
      Tokiyoshi, Ayabe., Toshifumi, Ashida., Yutaka, Kohgo., et al
    • Journal Title

      Trends Microbiol 12

      Pages: 394-398

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Presentation] Indications for leukocyte apheresis by centrifugal cell separator in UC2004

    • Author(s)
      Kohtaro, Okamoto., Toshifumi, Ashida., Atsuo. Maemoto., et al
    • Organizer
      Annual meeting of Japanese Apheresis Society
    • Place of Presentation
      Tokyo
    • Year and Date
      2004-11-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Presentation] 潰瘍性大腸炎における遠心分離式白血球除去療法の位置づけ2004

    • Author(s)
      岡本耕太郎, 蘆田知史, 石川千里, 他
    • Organizer
      日本アフェレシス学会
    • Place of Presentation
      東京
    • Year and Date
      2004-11-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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