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A Research Project for Diagnosis, Treatment and Pathophysiology of Small Intestinal Diseases Using Double-Balloon Endoscopy.

Research Project

Project/Area Number 16590623
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionJICHI MEDICAL UNIVERSITY

Principal Investigator

YAMAMOTO Hironori  JICHI MEDICAL UNIVERSITY, School of Medicine, Assistant Professor, 医学部, 助教授 (10311937)

Co-Investigator(Kenkyū-buntansha) SUGANO Kentaro  JICHI MEDICAL UNIVERSITY, School of Medicine, Professor, 医学部, 教授 (60179116)
KITA Hirota  JICHI MEDICAL UNIVERSITY, School of Medicine, Assistant Lecturer, 医学部, 助手 (80294974)
SUNADA Keijiro  JICHI MEDICAL UNIVERSITY, School of Medicine, Assistant Lecturer, 医学部, 助手 (90382853)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsDouble-Balloon Endoscopy / Small intestinal disease / enteroscopy / endoscopy / endoscopic treatment / small intestine / gastroenterology / bacterial flora / 小腸内視鏡検査 / 小腸出血 / 小腸腫瘍
Research Abstract

We have experienced more than 530 cases of enteroscopy using double-balloon endoscopy by the end of March 2006. From these experiences, we have established the insertion method of double-balloon endoscopy. We also established the therapeutic method in the small intestine, such as hemostasis, polypectomy, balloon dilation, stent placement and retrieval of foreign bodies.
We also performed a multi-center trial of a comparison between double-balloon endoscopy and capsule endoscopy in cooperation with Dokkyo University to establish the standard approaching strategy for the small intestinal diseases.
We also actively performed endoscopic approaches to a segment of intestinal tracts with surgically altered anatomy, which had been difficult with standard endoscopy, such as an afferent limb of Billroth II or Roux-en-Y reconstruction using double-balloon endoscopy. We established endoscopic billiary treatments with double-balloon endoscopy for such kind of patients.
We also performed multi-center … More trials of research on small intestinal diseases in a working group which is composed of Jichi Medical University, Nippon Medical University, Nagoya University, Kyoto University, Hiroshima University, Kyushu University and Fukuoka University. The working group was organized with the core members of the society for the study of small intestinal endoscopy which was established in 2003.
We also worked for international education and spreading of double-balloon endoscopy. As a result, double-balloon endoscopy is currently used in more than 33 countries in the world. There are already many publications from Europe, America and Oceania which report usefulness and safety of double-balloon endoscopy. Double-balloon endoscopy has been accepted as a new standard of enteroscopy in an international level. We have organized the 1st International Workshop on Double-Balloon Endoscopy which will be held at Tokyo in August of 2006 to share the experience, standardize the technique and improve our knowledge on small intestinal diseases. International committee of the workshop is composed of delegates from Japan, America, Canada, Germany, Netherlands, China and Korea.
Basic research on the small intestine using double-balloon endoscopy is also ongoing. Specifically, a researcher of our division is sent to the department of microbiology in our university for the study of the intestinal bacterial flora. Our first aim is to elucidate the normal bacterial flora of the human small intestine. Less

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (30 results)

All 2005 2004

All Journal Article (28 results) Book (2 results)

  • [Journal Article] Bleeding polyp in the mid small intestine identified by capsule endoscopy and treated by double-balloon endoscopy.2005

    • Author(s)
      Hiroto Kita, Hironori Yamamoto, Kentaro Sugano, et al.
    • Journal Title

      Gastrointestinal Endoscopy 61

      Pages: 628-629

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Double-balloon endoscopy.2005

    • Author(s)
      Hironori Yamamoto, Hiroto Kita.
    • Journal Title

      Current Opinion in Gastroenterology 21

      Pages: 573-577

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine.2005

    • Author(s)
      Sunada K., Yamamoto H., Kita H., et al.
    • Journal Title

      World J.Gastroenterol. 11

      Pages: 1087-1089

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Double-balloon endoscopy for ileal GI stromal tumor.2005

    • Author(s)
      Michiko Iwamoto, Hironori Yamamoto, Hiroto Kita, Keijiro Sunada, Kentaro Sugano, et al.
    • Journal Title

      Gastrointestinal Endoscopy 62

      Pages: 440-441

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Bleeding polyp in the mid small intestine identified by capsule endoscopy and treated by double-balloon endoscopy.2005

    • Author(s)
      H.Kita, H.Yamamoto, K.Sugano, et al.
    • Journal Title

      Gastrointestinal Endoscopy 61

      Pages: 628-629

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Double-balloon endoscopy.2005

    • Author(s)
      H.Yamamoto, H.Kita
    • Journal Title

      Current Opinion in Gastroenterology 21

      Pages: 573-577

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 小腸内視鏡挿入法 Double-balloon method2005

    • Author(s)
      山本 博徳
    • Journal Title

      日本大腸検査学会雑誌 22(2)

      Pages: 122-128

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ダブルバルーン内視鏡-小腸疾患に対する診断治療の最前線.2005

    • Author(s)
      山本 博徳
    • Journal Title

      Endoscopic Forum for digestive disease 21(2)

      Pages: 136-142

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 小腸内視鏡の現況。2005

    • Author(s)
      山本博徳, 喜多宏人, 砂田圭二郎, 矢野智則, 菅野健太郎 他
    • Journal Title

      日本消化器内視鏡学会雑誌 47(10)

      Pages: 2353-2360

    • NAID

      10016789951

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Double-balloon endoscopy.2005

    • Author(s)
      Yamamoto H.
    • Journal Title

      Clin Gastroenterol Hepatol. 3(7 Pt 2)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Bleeding polyp in the mid small intestine identified by capsule endoscopy and treated by double-balloon endoscopy.2005

    • Author(s)
      Kita H, Yamamoto H, Sugano K.et al.
    • Journal Title

      Gastrointest Endosc 61(4)

      Pages: 628-229

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine.2005

    • Author(s)
      Sunada K, Yamamoto H, Kita H, Yano T, Sugano K.et al.
    • Journal Title

      World J Gastroenterol 11(7)

      Pages: 1087-1089

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine.2005

    • Author(s)
      Sunada K, Yamamoto H, Kita H, et al.
    • Journal Title

      World J Gastroenterol 11(7)

      Pages: 1087-1089

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small intestine diseases.2004

    • Author(s)
      Yamamoto H., Kita H., Sunada K., et al.
    • Journal Title

      Clin.Gastroenterol.Hepatol. 2

      Pages: 1010-1016

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct observation with double-balloon enteroscopyt of an intestinal intramural hematoma resulting in anticoagulant ileus.2004

    • Author(s)
      Shinozaki S., Yamamoto H., Kita H., et al.
    • Journal Title

      Dig.Dis.Sci. 49

      Pages: 902-905

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Application of double-balloon enteroscopy through Roux-en-Yanastomosis for the EMR of an early carcinoma in the afferent duodenal limb.2004

    • Author(s)
      Kuno A., Yamamoto H., Kita H., et al.
    • Journal Title

      Gastointestinal Endoscopy 60

      Pages: 1032-1034

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gastrointestinal stromal tumor in the jejunum;diagnosisi and control of bleeding with electrocoagulation by using double-balloon enteroscopy.2004

    • Author(s)
      Nishimura m., Yamamoto H., Kita H., et al.
    • Journal Title

      J.Gastroenterol. 39

      Pages: 1001-1004

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Successful treatment with balloon dilatation using a double-balloon enteroscope for a stricture in the small bowel of a patient with Crohn's disease.2004

    • Author(s)
      Sunada K., Yamamoto H., Kita H., et al.
    • Journal Title

      Digestive Endoscopy 16

      Pages: 237-240

    • NAID

      10016171373

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A case of inflammatory fibroid polyp causing small-bowel intussusception in which retrograde double-balloon enteroscopy was useful for the preoperative diagnosis.2004

    • Author(s)
      Miyata T., Yamamoto H., Kita H., et al.
    • Journal Title

      Endoscopy 36

      Pages: 344-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small intestine diseases.2004

    • Author(s)
      Yamamoto H., Kita H., Sunada K.et al.
    • Journal Title

      Clin.Gastroenterol.Hepatol. 2

      Pages: 1010-1016

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Direct observation with double-balloon enteroscopy of an intestinal intramural hematoma resulting in anticoagulant ileus.2004

    • Author(s)
      Shinozaki S., Yamamoto H., Kita H., et al.
    • Journal Title

      Dig.Dis.Sci. 49

      Pages: 902-905

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Application of double-balloon enteroscopy through Roux-en-Y anastomosis for the EMR of an early carcinoma in the afferent duodenal limb.2004

    • Author(s)
      Kuno A., Yamamoto H., Kita H., et al.
    • Journal Title

      Gastrointestinal Endoscopy 60

      Pages: 1032-1034

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gastrointestinal stromal tumor in the jejunum ; diagnosis and control of bleeding with electrocoagulation by using double-balloon enteroscopy.2004

    • Author(s)
      Nishimura M., Yamamoto H., Kita H., et al.
    • Journal Title

      J.Gastroenterol. 39

      Pages: 1001-1004

    • NAID

      10013798279

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical Outcomes of Double-Balloon Endoscopy for the Diagnosis and Treatment of Small Intestinal Diseases.2004

    • Author(s)
      Yamamoto H, Kita H, Sunada K, et al.
    • Journal Title

      Clinical Gastroenterology and Hepatology 2(11)

      Pages: 1010-1016

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ダブルバルーン内視鏡を用いた小腸内視鏡検査の有用性2004

    • Author(s)
      山本博徳, 喜多宏人, 砂田圭二郎, 他
    • Journal Title

      日本消化器病学会雑誌 101

      Pages: 976-982

    • NAID

      10013672336

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Direct Observation with Double-Balloon Enteroscopy of an Intestinal Intramural Hematoma Resulting in Anticoagulant Ileus.2004

    • Author(s)
      Shinozaki S, Yamamoto H, Kita H, et al.
    • Journal Title

      Digestive Diseases and Sciences 49

      Pages: 902-905

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Application of double-balloon enteroscopy through Roux-en-Y anastomosis for the endoscopic mucosal resection of an early carcinoma in the duodenal afferent limb.2004

    • Author(s)
      Kuno A, Yamamoto H, Kita H, et al.
    • Journal Title

      Gastrointestinal Endoscopy 60

      Pages: 1032-1034

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Gastrointestinal stromal tumor in the jejunum : diagnosis and control of bleeding with electrocoagulation by using double-balloon enteroscapy.2004

    • Author(s)
      Nishimura M, Yamamoto H, Kita H, et al.
    • Journal Title

      Journal of Gastroenterology 39

      Pages: 1001-1004

    • Related Report
      2004 Annual Research Report
  • [Book] Annual Review 消化器 2005(分担執筆)2005

    • Author(s)
      山本 博徳
    • Total Pages
      7
    • Publisher
      中外医学社
    • Related Report
      2005 Annual Research Report
  • [Book] ダブルバルーン内視鏡-理論と実際-2005

    • Author(s)
      山本博徳, 喜多宏人, 砂田圭二郎, 他
    • Total Pages
      115
    • Publisher
      南江堂
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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