Analysis of Regulation of intercellular junctional system of gastric mucosa
| Project/Area Number |
16590635
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokai University |
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Principal Investigator |
MINE Tetsuya Tokai University, Department of Internal Medicine, Professor, 医学部, 教授 (20157572)
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| Co-Investigator(Kenkyū-buntansha) |
TAKASHIMIZU Shinji Tokai University, Department of Internal Medicine, instructor, 医学部, 助手 (60317815)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | intercellular junction apparatus / connexin32 / knockout mouse / adherence junction / tight junction / gap junction / desmosome / ギャップジャンクション / クロウディン / ZO1 / ZO2 / カドヘリン / カテニン |
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| Research Abstract |
There are four types of intercellular junction apparatuses : Desmosome, Tight junction, Adeherence junction and Gap junction. We investigated the mutual dependency of the development of these intercellular junction apparatuses. We checked each apparatus in gastric mucosa by electronmicroscopy using connexin32 knockout mouse. In the connexin32 knockout mouse, we could not detect gap junction in gastric mucosa. In contract, we could detect the desmosomes, tight junctions, and adherence junctions on gastric mucosa of connexin32 knockout mouse. From these findings, we concluded the followings : 1) To make connexin32, a protein of gap junction, knock out, no substitution for connexin32 occurs, even though there are many kinds of gap junction protein. 2) Even if making gap junction delete, no influence on desmosomes, tight junctions, and adherence junctions occurs.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent refluxoesophagitis.2005
Author(s)
Ohkusa T, Maekawa T, Arakawa T, Nakajima M, Fujimoto K, Hoshino E, Mitachi Y, Hamada S, Mine T.Kawahara Y, Nagai T, Aoyama N, Yoshida N, Tadokoro K, Chida N, Konda Y, Seno H, Shimatani T, Ino-ue M, Sato N
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Journal Title
Alim Pharmacol Ther. 21-11
Pages: 1331-1339
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C2004
Author(s)
Mochizuki K, Kagawa T, Takashimizu S, Kawazoe K, Kojima S, Nagata N, Nakano A, Nishizaki Y, Shiraishi K, Itakura M, Watanabe N, Mine T, Matsuzaki S.
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Journal Title
World J Gastroenterol 10(5)
Pages: 733-736
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant2004
Author(s)
Kagawa T, Watanabe N, Kanouda H, Takayama I, Shiba T, Kanai T, Kawazoe K, Takashimizu S, Kumaki N, Shimamura, K, Matsuzaki S, Mine T.
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Journal Title
World J Gastroenterol 10(11)
Pages: 1686-1687
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet2004
Author(s)
Chen Y, Hozawa S, Sawamura S, Sato S, Fukuyama N, Tsuji C, Mine T, Okada Y, Tanino R, Ogushi Y, Nakazawa H.
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Journal Title
Biochem Biophys Res Commun. 326(1)
Pages: 45-51
Description
「研究成果報告書概要(欧文)」より
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