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Analysis of Regulation of intercellular junctional system of gastric mucosa

Research Project

Project/Area Number 16590635
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionTokai University

Principal Investigator

MINE Tetsuya  Tokai University, Department of Internal Medicine, Professor, 医学部, 教授 (20157572)

Co-Investigator(Kenkyū-buntansha) TAKASHIMIZU Shinji  Tokai University, Department of Internal Medicine, instructor, 医学部, 助手 (60317815)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsintercellular junction apparatus / connexin32 / knockout mouse / adherence junction / tight junction / gap junction / desmosome / ギャップジャンクション / クロウディン / ZO1 / ZO2 / カドヘリン / カテニン
Research Abstract

There are four types of intercellular junction apparatuses : Desmosome, Tight junction, Adeherence junction and Gap junction. We investigated the mutual dependency of the development of these intercellular junction apparatuses. We checked each apparatus in gastric mucosa by electronmicroscopy using connexin32 knockout mouse. In the connexin32 knockout mouse, we could not detect gap junction in gastric mucosa. In contract, we could detect the desmosomes, tight junctions, and adherence junctions on gastric mucosa of connexin32 knockout mouse. From these findings, we concluded the followings : 1) To make connexin32, a protein of gap junction, knock out, no substitution for connexin32 occurs, even though there are many kinds of gap junction protein. 2) Even if making gap junction delete, no influence on desmosomes, tight junctions, and adherence junctions occurs.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (33 results)

All 2006 2005 2004

All Journal Article (29 results) Book (4 results)

  • [Journal Article] A case of adult-onset type II citrullinemia-deterioration of clinical course after infusion of hyperosmotic and high sugar solutions2006

    • Author(s)
      Takahashi H, Kagawa T, Kobayashi K, Hirabayashi H, Yui M, Begum L, Mine T. Takagi S, Saheki T, Shinohara Y
    • Journal Title

      Med Sci Monit 12:CS

      Pages: 13-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The role of dehydroepiandrosterone in apoptosis and proliferation and its relation to the phosphatidyl inositol-3-kinase/ Akt signaling pathway.2005

    • Author(s)
      Mine T
    • Journal Title

      J. Gastroenterol 40・5

      Pages: 553-4

    • NAID

      10015648395

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent reflux oesophagitis. Alim Pharmacol Ther.2005

    • Author(s)
      Mine T
    • Journal Title

      21・11

      Pages: 1331-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of Helicobacter pylori eradication in patients with chronic idiopathic thrombocytopenic purpuraa randomized controlled trial.2005

    • Author(s)
      Suzuki T, Mine T
    • Journal Title

      Am J Gastroenterol 100・6

      Pages: 1265-70

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Characteristics of a clinical isolate of urease-negative Helicobacter pylori and its ability to niduce gastric ulcers in Mongolial gerbils.2005

    • Author(s)
      Mine T
    • Journal Title

      Hericobacter 10・2

      Pages: 125-31

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mitochondrial DNA mutation and functional dyspepsia2005

    • Author(s)
      Mine T
    • Journal Title

      Intern Med 44・2

      Pages: 87-8

    • NAID

      10014377371

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] The role of dehydroepiandrosterone in apoptosis and proliferation and its relation to the phosphatidyl inositol-3-kinase/ Akt signaling pathway.2005

    • Author(s)
      Mine T.
    • Journal Title

      J Gastroenterol 40-5

      Pages: 553-554

    • NAID

      10015648395

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent refluxoesophagitis.2005

    • Author(s)
      Ohkusa T, Maekawa T, Arakawa T, Nakajima M, Fujimoto K, Hoshino E, Mitachi Y, Hamada S, Mine T.Kawahara Y, Nagai T, Aoyama N, Yoshida N, Tadokoro K, Chida N, Konda Y, Seno H, Shimatani T, Ino-ue M, Sato N
    • Journal Title

      Alim Pharmacol Ther. 21-11

      Pages: 1331-1339

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of Helicobacter pylori eradication in patients with chronic idiopathic thrombocytopenic purpuraa randomized controlled trial.2005

    • Author(s)
      Suzuki T, Matsushima M, Masui A, Watanabe K, Takagi A, Ogawa Y, Shirai T, Mine T.
    • Journal Title

      Am J Gastroenterol 100-6

      Pages: 1265-1270

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of a clinical isolate of urease-negative Helicobacter pylori and its ability to niduce gastric ulcers in Mongolial gerbils.2005

    • Author(s)
      Mine T.Muraoka H, Saika T, Kobayashi I
    • Journal Title

      Helicobacter 10-2

      Pages: 125-131

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mitochondrial DNA mutation and functional dyspepsia2005

    • Author(s)
      Mine T.
    • Journal Title

      Intern Med 44-2

      Pages: 87-88

    • NAID

      10014377371

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Virulent Klebsiella preumoniae strains and liver abscess with metastatic lesions2005

    • Author(s)
      Mine T.
    • Journal Title

      Hepatol Res 31

      Pages: 5-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The role of dehydroepiandrosterone in apoptosis and proliferation and its relation to the phosphatidyl inositol-3-kinase/ Akt signaling pathway.2005

    • Author(s)
      Mine T
    • Journal Title

      J Gastroenterol 40・5

      Pages: 553-554

    • NAID

      10015648395

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of CYP2C19 polymorphism on the safety and efficacy of omeprazole in Japanese patients with recurrent reflux oesophagitis.2005

    • Author(s)
      Mine T
    • Journal Title

      Alim Pharmacol Ther. 21・11

      Pages: 1331-1339

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characteristics of a clinical isolate of urease-negative Helicobacter pylori and its ability to niduce gastric ulcers in Mongolial gerbils.2005

    • Author(s)
      Mine T
    • Journal Title

      Helicobacter 10・2

      Pages: 125-131

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Virulent Klebsiella pneumoniae strains and liver abscess with metastatic lesions.2005

    • Author(s)
      Mine T
    • Journal Title

      Hepatol Res 31.1

      Pages: 5-6

    • NAID

      10015455849

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dificiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet.2005

    • Author(s)
      Chen Y, Hozawa S, Sawamura S, Sato S, Fkuyama N, Tsuji C, Mine T
    • Journal Title

      Biochem Biophys Res Commun 326.1

      Pages: 45-51

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C2004

    • Author(s)
      Mochizuki K, Kagawa T, Takashimizu S, Kawazoe K, Kojima S, Nagata N, Nakano A, Nishizaki Y, Shiraishi K, Itakura M, Watanabe N, Mine T, Matsuzaki S.
    • Journal Title

      World J Gastroenterol 10(5)

      Pages: 733-736

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer2004

    • Author(s)
      Sakuma T, Kijima H, Nishi M, Abe Y, Yamazaki H, Mine T, Nakamura M, Ueyama Y.
    • Journal Title

      Tokai J Exp Clin Med 29(2)

      Pages: 35-42

    • NAID

      110004700373

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hypereosinophilic syndrome vs eosinophilic gastroenteritis2004

    • Author(s)
      Mine T.
    • Journal Title

      Intern Med 43(4)

      Pages: 277-278

    • NAID

      10012889519

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant2004

    • Author(s)
      Kagawa T, Watanabe N, Kanouda H, Takayama I, Shiba T, Kanai T, Kawazoe K, Takashimizu S, Kumaki N, Shimamura, K, Matsuzaki S, Mine T.
    • Journal Title

      World J Gastroenterol 10(11)

      Pages: 1686-1687

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Helicobacter pylori induces chronic active gastritis in p53-knockout mice2004

    • Author(s)
      Nagata J, Kijima H, Takagi A, Ito M, Goto K, Yamazaki H, Nakamura M, Mine T, Ueyama Y.
    • Journal Title

      Int J Mol Med 13(6)

      Pages: 773-777

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet2004

    • Author(s)
      Chen Y, Hozawa S, Sawamura S, Sato S, Fukuyama N, Tsuji C, Mine T, Okada Y, Tanino R, Ogushi Y, Nakazawa H.
    • Journal Title

      Biochem Biophys Res Commun. 326(1)

      Pages: 45-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protein-losing gastroenteropathy associated with Sjogren syndrome-case report and review of the Japanese literature2004

    • Author(s)
      Ushiyama A, Teraoka H, Shiba T, Saito T, Nagata J, Koike J, Mine T
    • Journal Title

      Nippon Syokakibyo Gakkai Zassi 101.12

      Pages: 1314-1319

    • NAID

      10014247255

    • Related Report
      2004 Annual Research Report
  • [Journal Article] An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer.2004

    • Author(s)
      Sakuma T, Kijima H, Nishi M, Abe Y, Yamazaki H, Mine T
    • Journal Title

      Tokai J Exp Clin Med. 29.2

      Pages: 35-42

    • NAID

      110004700373

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hypereosinophilic syndrome vs eosinophilic gastroenteritis.2004

    • Author(s)
      Mine T
    • Journal Title

      Intern Med 43.4

      Pages: 277-278

    • NAID

      10012889519

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Fatal liver failure due to reactivation of lamivudine-resistant HBV mutant.2004

    • Author(s)
      Kagawa T, Watanabe N, Kanouda H, Takayama I, Shiba T, Mine T
    • Journal Title

      World J Gastroenterol 10.11

      Pages: 1686-1687

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Helicobacter pylori induces chronic active gastritis in p53-knockout mice.2004

    • Author(s)
      Nagata J, Kijima H, Takagi A, Ito M, Goto K, Yamazaki H, Mine T
    • Journal Title

      Int J Mol Med. 13.6

      Pages: 773-777

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive....2004

    • Author(s)
      Mochizuki K, Kagawa T, Takashimizu S, Kawazoe K, Kojima S, Mine T
    • Journal Title

      World J Gastroenterol 10.5

      Pages: 733-736

    • Related Report
      2004 Annual Research Report
  • [Book] サイトプロテクション2006

    • Author(s)
      峯 徹哉
    • Publisher
      癌と化学療法社
    • Related Report
      2005 Annual Research Report
  • [Book] サイトプロテクション2005

    • Author(s)
      峯 徹哉
    • Publisher
      癌と化学療法社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] シュミレイション内科 上部消化管疾患を探る2004

    • Author(s)
      峯 徹哉
    • Total Pages
      175
    • Publisher
      株式会社 永井書店
    • Related Report
      2004 Annual Research Report
  • [Book] 消化器内視鏡のトラブル防止マニュアル2004

    • Author(s)
      峯 徹哉
    • Total Pages
      298
    • Publisher
      株式会社 日本メディカルセンター
    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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