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心不全におけるサイトカイン信号伝達分子gp130を介した遺伝子ネットワークの解析

Research Project

Project/Area Number 16590681
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

廣田 久雄  阪大, 医学(系)研究科(研究院), 助手 (30273684)

Co-Investigator(Kenkyū-buntansha) 瀧原 圭子  大阪大学, 保健センター, 助教授 (70252640)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsgp130 / LIF / DNA microarray / 心筋細胞 / PPARdelta / CPT-1
Research Abstract

gp130の関連サイトカインのひとつであるleukemia inhibitory factor(LIF)刺激後3時間の培養心筋細胞よりRNAの調整、cDNAライブラリーの作成をする。gp130活性化後の細胞内におけるすべての遺伝子の発現量を一度にモニターするシステムとしてDNA microarray法を使用した。発現増強が認められた(2倍を陽性とした)遺伝子群は大きく2つに分けられた。()内の数字は発現増強度。A.gp130情報伝達関連分子:suppressor of cytokine signaling-3(10.67)、CCAAT enhancer-binding protein delta(10.39)、vav2(4.37)、n-myc(4.31)、junB(3.59)、lck(2.80)、Janus protein tyrosine kinase 2(2.51)、PI3K(2.33)、ERK5(2.21)。B.エネルギー代謝関連分子:Insulin-like growth factor II receptor(9.98)、hexokinase II(4.45)、adiponectin receptor(2.97)、peroxisome proliferators-activated receptor(PPAR) delta(2.65)、Sulfonylurea receptor 2B(2.30)。新たな心不全治療の標的として心筋細胞におけるエネルギー産生系の分子制御はひとつの大きな可能性である。そこで我々はPPAR deltaに注目した。アデノウイルスを用いたgain-of-functionおよびloss-of-function実験で、PPARdeltaが心筋における脂肪酸代謝の重要な酵素であるcarnitine palmitoyltransferase-1(CPT-1)を制御していることが観察された。

Report

(1 results)
  • 2004 Annual Research Report
  • Research Products

    (7 results)

All 2005 2004

All Journal Article (6 results) Book (1 results)

  • [Journal Article] Smad1 Protects Cardiomyocytes from Ischemia-Reperfusion Injury.2005

    • Author(s)
      Masaki M, et al.
    • Journal Title

      Circulation In press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Solitary Right Ventricle Metastasis by Renal Cell Carcinoma.2004

    • Author(s)
      Masaki M, et al.
    • Journal Title

      J Am Soc Echocardiog 17

      Pages: 397-398

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Circulating Interleukin-6 Family Cytokines and their Receptors in Patients with Congestive Heart Failure.2004

    • Author(s)
      Hirota H, et al.
    • Journal Title

      Heart Vessels 19

      Pages: 237-241

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Novel Insertional Mutation in the Bone Morphogenetic Protein Receptor type II Associated with Sporadic Primary Pulmonary Hypertension.2004

    • Author(s)
      Sugiyama S, et al.
    • Journal Title

      Circulation Journal 68

      Pages: 592-594

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Smad1 protects cardiomyocytes from ischemia-reperfusion injury2004

    • Author(s)
      Masaki M, et al.
    • Journal Title

      Circulation 110

      Pages: 276-276

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Smad1 inhibits human pulmonary artery smooth muscle cell proliferation.2004

    • Author(s)
      Hirota H, et al.
    • Journal Title

      Circulation 110

      Pages: 169-169

    • Related Report
      2004 Annual Research Report
  • [Book] SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION(STATs) ACTIVATION AND BIOLOGY, CHAPTER 44 STATs in Cardiovascular System.2004

    • Author(s)
      Hirota H.
    • Total Pages
      746
    • Publisher
      Kluwer Academic Publishers Dordrecht
    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

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