Novel anti-atherosclerotic and anti-thrombotic action of plasma heparin cofactor II
| Project/Area Number |
16590692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AZUMA Hiroyuki The University of Tokushima, Institute of Health Biosciences, Graduate School, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (10241275)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUI Takao The University of Tokushima, University Medical and Dental Hospital, Lecturer, 医学部・歯学部附属病院, 講師 (80294726)
AKAIKE Masashi The University of Tokushima, University Medical and Dental Hospital, Assistant, 医学部・歯学部附属病院, 助手 (90271080)
池田 康将 徳島大学, 医学部・歯学部附属病院, 医員(臨床)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | thrombin / heparin cofactor II / atherosclerosis / coronary intervention / knockout mice / vascular remodeling / vascular smooth muscle cell / thrombin receptor / PCI / PAR |
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| Research Abstract |
HCII+/- mice we generated had about 60% of plasma HCII activity. Cuff placement around femoral artery for 4 weeks caused prominent neointimal and adventitial hyperplasia with augmented expression of protease-activated receptor 1 in HCII+/- mice compared with HCII+/+ mice. These exacerbated vascular remodeling was ameliorated to similar level as HCII+/+ mice by administration of purified human HCII protein.
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Report
(3 results)
Research Products
(14 results)
