| Project/Area Number |
16590725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The Tazuke Kofukai, Medical Research Institute |
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Principal Investigator |
NOHARA Ryuji The Tazuke Kofukai, Medical Research Institute Third division, Head Researcher, 医学研究所第3研究部, 部長 (80180769)
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| Co-Investigator(Kenkyū-buntansha) |
INOKO Moriaki The Tazuke Kofukai, Medical Research Institute Third division, Researcher, 医学研究所第3研究部, 研究員 (00324624)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2004: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | plaque / IVRD / RI / ^<18>F-FDG / Myocardial Infarction / radiation / FDG / arteriosclerosis / 動脈硬化 / 血栓 / LOX-1 |
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| Research Abstract |
Detection of vulnerable plaques before rupture is important in preventing acute coronary events such as myocardial infarction. Although the therapeutic strategies such as per-cutaneous trans-luminal coronary angioplasty(PTCA) appear to prevent coronary occlusion and consequently may lead to improved prognosis in these patients, a method of detecting vulnerable plaques has not been established, even with CT, MRI and IVAS. A nuclear method that uses an intravascular radiation detector (IVRD) with the plaques-avid tracer F-18 FDG is one of the most promising method. The catheter used IVRD consists of catheter probe (a scintillator and flexible optic fibers), photomultipliers, a controller, and an automatic pull back unit and personal computer. A phantom study demonstrated that this detector was highly sensitive to F-18 and enabled the detection of F-18 FDG point sources. In addition to these study, we found that the newly developed catheter-based IVRD was able to detect, with good resolution, the slight radioactivity from F-18 point sources attached to the dog femoral artery and the coronary adventitia. The swine heart was tried with this catheter, and IVRD was successfully controlled in the coronary artery, and extra-coronary radioactive source was detected, even the back ground activity was increased. Additional calculation using simulation method showed that F-18 FDG injection might be feasible to detect the plaque count with this catheter. These results show that catheter(IVRD) based detection of coronary vulnerable plaques may be feasible.
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