| Project/Area Number |
16590727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
KISHIMOTO Ichiro National Cardiovascular Center Research Institute, Hypertension Research Laboratory, Chief, 病因部高血圧研究室, 室長 (80312221)
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| Co-Investigator(Kenkyū-buntansha) |
KANGAWA Kenji National Cardiovascular Center Research Institute, Department of Biochemistry, Head, 副所長 (00112417)
NAGAYA Noritoshi National Cardiovascular Center Research Institute, Department of Regenrative Medicine, Head, 再生医療部, 部長 (60372116)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Myocardial Infarction / Ghrelin / Cardiac Remodeling / Fibrosis / Hypertrophy |
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| Research Abstract |
We assessed the hypothesis that the in vivo administration of Ghrelin might attenuate cardiac late remodeling and prevent heart failure after myocardial infarction (MI). When Ghrelin was administered for 2 weeks in rats with MI, the heart rate was decreased without alteration in arterial pressure. LV enlargement induced by MI was significantly attenuated by ghrelin treatment. Moreover, there was a substantial decrease in LV end-diastolic pressure, and increases in dP/dt max/min in ghrelin-treated MI rats compared to saline-treated MI rats. Ghrelin attenuated an increase in morphometrical collagen volume fraction in the non-infarct region. In conscious rats after MI, acute administration of ghrelin decreased the low-frequency/high-frequency ratio of heart rate variability obtained by a telemetry system. These data suggest the potential usefulness of ghrelin as a new anti-remodeling agent after MI.
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