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Study on the pathogenesis and treatment of COPD exacerbation caused by airway virus infection.

Research Project

Project/Area Number 16590732
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

YAMAYA Mutuso  Tohoku University, Hospital, Associate Professor, 病院, 助教授 (60261640)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsRhinovirus / Respiratory syncytial virus / COPD / MUCIN / Defensin / Lansoprazole / Macrolide antibiotics / プロトンポンプ阻害薬
Research Abstract

We examined the mechanisms of airway mucus production by rhinovirus (RV) infection associated with exacerbations of chronic obstructive pulmonary disease. RV infection increased mRNA of various mucins including MUC5AC, and content of MUC5AC in supernatants in cultured human tracheal epithelial cells and submucosal gland cells. Pathways including NF-κB, p44/42 mitogen-activated protein kinase and Src were suggested to be associated with the mucin secretion. These findings suggest the direct stimulation of RV infection on mucin secretion from airway epithelial cells. 2.We examined the effects of RV infection on the production of human beta-defensin (HBD) in airway epithelial cells. We found that RV infection stimulated the production of HBD-1 and HBD-3. These findings suggest the protective effects of RV infection from bacterial infection. 3.We examined the inhibitory effects of a proton pump inhibitor on RV infection. We found that lansoprazole, a proton pump inhibitor, reduced viral titers of RV and cytokine content in supernatants, and RV RNA replication in the airway epithelial cells. These findings suggest that lansporazole may inhibit RV infection. 4.We examined the inhibitory effects of macrolide antibiotics on RS (respiratory syncytial) virus infection. We found that erythromycin, clarithromycin and bafilomycin reduced viral titers of RS virus and cytokine content in supernatants in the airway epithelial cells. These findings suggest that macrolide antibiotics may inhibit RS virus infection.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (21 results)

All 2006 2005 2004

All Journal Article (20 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Carbocisteine reduces frewurncy of common colds and exacerbations in COPD patients.2006

    • Author(s)
      Yasuda H, Yamaya M et al.
    • Journal Title

      J.Am.Geriatr.Soc. 54

      Pages: 378-380

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanisms of mucin production by rhinovirus infection in cultured human tracheal surface epithelium and submucosal glands.2006

    • Author(s)
      Inoue D, Yamaya M et al.
    • Journal Title

      Respir.Physiol.Neurobiol. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells.2006

    • Author(s)
      Yasuda H, Yamaya M et al.
    • Journal Title

      Eur.Respir.J. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carbocisteine reduces frequency of common colds and exacerbations in COPD patients.2006

    • Author(s)
      Yasuda H, Yamaya M, Sasaki T, Inoue D, Nakayama K, Tomita N, Yoshida M, Sasaki H.
    • Journal Title

      J Am Geriatr Soc 54

      Pages: 378-380

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanisms of mucin production by rhinovirus infection in cultured human tracheal surface epithelium and submucosal glands.2006

    • Author(s)
      Inoue D, Yamaya M, Sasaki T, Hosoda M, Kubo H, Numazaki M, Tomioka Y, Yasuda H, Sekizawa K, Nishimura H, Sasaki H.
    • Journal Title

      Respiration Physiology Neurobiolog (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells.2006

    • Author(s)
      Yasuda H, Yamaya M, Sasaki T, Inoue D, Nakayama K, Yamada M, Suzuki T, Sasaki H.
    • Journal Title

      Eur Respir J (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A proton pump inhibitor lansoprazole inhibits rhino-virus infection in cultured human tracheal epitheial cells.2005

    • Author(s)
      Sasaki T, Yamaya M et al.
    • Journal Title

      Eur.J.Pharm. 509

      Pages: 201-210

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Erythromycin increases bactericidal activity of surface liquid in human airway epithelial cells.2005

    • Author(s)
      Ishizawa K et al.
    • Journal Title

      Am.J.Physiol. 289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells.2005

    • Author(s)
      Sasaki T, Yamaya M, Yasuda H, Inoue D, Yamada M, Nishimura H, Sasaki H.
    • Journal Title

      Eur J Pharm 509

      Pages: 201-210

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Erythromycin increases bactericidal activity of surface liquid in human airway epithelial cells.2005

    • Author(s)
      Ishizawa K, Suzuki T, Yamaya M, Jia YX, Kobayashi S, Ida S, Kubo H, Sekizawa K, Sasaki H.
    • Journal Title

      Am J Physiol 289

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A proton pump inhibitor lanssoprazole inhibits rhinovirus infection in cultured human tracheal epitheal cells.2005

    • Author(s)
      Sasaki T, Yamaya M, et al.
    • Journal Title

      Eur J Pharmacol 509

      Pages: 201-210

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Erythromycin increases bactericidal activity of surface liguid in human airway epithelial cells.2005

    • Author(s)
      Ishizawa K, Yamaya M, et al.
    • Journal Title

      Am J Physiol 289

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells.2005

    • Author(s)
      Sasaki T, et al
    • Journal Title

      Eur J Pharm (In Press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Human airway submucosal glands augment eosinophil ehematoxis during rhinovirus infection2004

    • Author(s)
      Furukawa E, et al.
    • Journal Title

      Clin.Exp.Allergy 34

      Pages: 704-711

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Human airway submucosal glands augment eosinophil chemotaxis during rhinovirus infection.2004

    • Author(s)
      Furukawa E, Ohrui T, Yamaya M, Suzuki T, Nakasato H, Sasaki T, Kanda A, Yasuda H, Nishimura H, Sasaki H.
    • Journal Title

      Clin Exp Allergy 34

      Pages: 704-711

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rhinovirus and airway allergey.2004

    • Author(s)
      Yamaya M, et al
    • Journal Title

      Allergology International 53

      Pages: 37-45

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increaseda arteio-venous Hb-CO differences in inflammatory pulmonary diseases.2004

    • Author(s)
      Yasuda H, et al
    • Journal Title

      Chest 125

      Pages: 2160-2168

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Human airway submucosal glands augment eosinophil chemotaxis during rhinovirus.2004

    • Author(s)
      Furukawa E, et al
    • Journal Title

      Clin Exp Allergy 34

      Pages: 704-711

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased arterial carboxyhemoglobin concentrations in elderly patients with silicosis.2004

    • Author(s)
      Yasuda H, et al
    • Journal Title

      J Am Geriatr Soc 52

      Pages: 1403-1404

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Arterial carboxyhemoglobin concentrations in elderly patients with operable non-small cell lung cancer.2004

    • Author(s)
      Yasuda H, et al
    • Journal Title

      J Am Geriatr Soc 52

      Pages: 1592-1593

    • Related Report
      2004 Annual Research Report
  • [Patent(Industrial Property Rights)] ライノウイルス感染予防剤2004

    • Inventor(s)
      山谷睦雄 他
    • Industrial Property Rights Holder
      山谷睦雄 他
    • Industrial Property Number
      2004-098995
    • Filing Date
      2004-04-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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