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GENETIC PREDISPOSITION, INFLAMMATION, INTERMITTENT HYPOXIA AND CARDIOVASCULAR COMPLICATIONS IN SLEEP APNEA SYNDROME

Research Project

Project/Area Number 16590735
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionChiba University

Principal Investigator

TATSUMI Koichiro  Chiba University, Department of Respirology, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (10207061)

Co-Investigator(Kenkyū-buntansha) KASAHARA Yasunori  Chiba University, Department of Respirology, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (60343092)
KUROSU Katushi  Chiba University, Department of Respirology, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (20291106)
TANABE Nobuhiro  Chiba University, Department of Respirology, Chiba University Hospital, Assistant Professor, 医学部付属病院, 講師 (40292700)
TAKIGUCHI Yuichi  Chiba University, Department of Respirology, Chiba University Hospital, Assistant Professor, 医学部付属病院, 講師 (30272321)
KURIYAMA Takayuki  Chiba University, Department of Respirology, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (20009723)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordssleep apnea syndrome / hypoxemia / visceral fat accumulation / leptin / obesity / 内蔵肥満
Research Abstract

Background : Obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by repeated oxygen desaturation. Obesity and visceral fat accumulation (VFA) are risk factors for the development of OSAHS. Circulating leptin increases in accordance with body mass index (BMI), and under experimental conditions intermittent hypoxia stimulates leptin production.
Methods : The primary objective of this study was to investigate whether hypoxemia during sleep influences the levels of circulating leptin and whether the location of body fat deposits, i.e. the distribution of VFA and subcutaneous fat accumulation (SFA), affects circulating leptin levels in patients with OSAHA who are not obese. We assessed VFA and SFA by abdominal CT scan and measured circulating levels of leptin in 96 male patients with OSAHS and 52 male patients without OSAHS matched for BMI. To be matched for BMI in the two groups, patients whose BMI was less than 27 kg/m^2 were selected for the OSAHS group.
Results : In the whole study group, circulating leptin levels correlated with BMI (r=0.30), VFA (r=0.44), SFA (r=0.28), apnea-hypopnea index (AHI) (r=0.48), sleep mean SaO_2 (r=0.59) and sleep lowest SaO_2 (r=037). Multiple regression analysis showed that average SaO_2 (P<0.01) and lowest SaO_2 (P=0.03) were explanatory variables for serum leptin values, but AHI (P=0.054), BMI (P=0.33), VFA (P=0.11) and SFA (P=0.36) were not.
Conclusions : These results suggest that sleep hypoxemia may be the main determinant of circulating leptin levels, although the location of body fat deposits could contribute to the elevated circulating leptin levels in patients with OSAHS who are not obese.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (6 results)

All 2005

All Journal Article (6 results)

  • [Journal Article] Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea sybdrome2005

    • Author(s)
      Tsutsumi K, et al.
    • Journal Title

      Chest 127

      Pages: 716-721

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fat accumulation, leptin and hypercapnia in obstructive sleep apne a-hypopnea syndrome2005

    • Author(s)
      Tsutsumi K, et al.
    • Journal Title

      Chest 127

      Pages: 543-549

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fat accumulation, leptin and hypercapnia in obstructive sleep apnea-hypopnea syndrome.2005

    • Author(s)
      Tatsumi K, et al.
    • Journal Title

      Chest 127

      Pages: 543-549

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome.2005

    • Author(s)
      Tatsumi K, et al.
    • Journal Title

      Chest 127

      Pages: 716-721

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome2005

    • Author(s)
      Tatsumi K, et al.
    • Journal Title

      Chest 127

      Pages: 716-721

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fat accumulation leptin and hypercapnia in obstructive sleep apnea-hypopnea syndrome2005

    • Author(s)
      Tatsumi K, et al.
    • Journal Title

      Chest 127

      Pages: 543-549

    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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