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New Therapeutic Approach using Bone Marrow Transplantation for Hereditary Glomerulonephritis, Alport Syndrome

Research Project

Project/Area Number 16590785
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionMie University

Principal Investigator

NOMURA Shinsuke  Mie University, Hospital Hemodialysis Center, Associate Professor, 医学部附属病院, 助教授 (20198625)

Co-Investigator(Kenkyū-buntansha) NAITO Ichiro  Okayama University, Graduate School of Medicine and Dentistry, Department of Human Morphology, Assistant Professor, 大学院・医歯学総合研究科, 助手 (60362993)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsAlport syndrome / Gene therapy / Glomerular basement membrane / Type IV collagen α chain / Bone marrow transplantation / 遺伝性腎疾患 / 遺伝子導入
Research Abstract

We have observed the improvement of life expectancy and renal survival rate among the affected animals, COL4A3 knockout mice, a model of human hereditary glomerulonephritis ; Alport syndrome, if these animals receive the bone marrow transplantation. Also, the histological finding of these animals were better than those of the animal without transplantation.
For the next step of our therapeutic approach, we have almost completed the retrovirus vector which includes the gene of mice COL4A3. We are going to carry out the cell therapy infected by such retrovirus, and also to produce a transgenic mice of the COL4A3.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (6 results)

All 2006 2005

All Journal Article (6 results)

  • [Journal Article] Comparison between valsartan and valsartan plus cilnidipine in type II diabetics with normo- and microalbuminuria.2006

    • Author(s)
      Katayama K, Nomura S, et al.
    • Journal Title

      Kidney Int. (Printing)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparison between valsartan and valsartan plus cilnidipine in type II diabetics with normo-and microalbuminuria.2006

    • Author(s)
      Katayama K, Nomura S, et al.
    • Journal Title

      Kidney Int. (in printing)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative immunoelectron-microscopic analysis of the type IV collagen alphal 1-6 chains in the glomerular basement membrane in childhood thin basement membrane disease.2005

    • Author(s)
      Akazawa H, Naito I, et al.
    • Journal Title

      Clin Nephrol. 64・5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma.2005

    • Author(s)
      Nagatsuka H, Naito I, et al.
    • Journal Title

      Virchows Arch. 447・4

      Pages: 710-716

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Quantitative immunoelectron-microscopic analysis of the type IV collagen alpha1-6 chains in the glomerular basement membrane in childhood thin basement membrane disease.2005

    • Author(s)
      Akawaza H, Naito I, et al.
    • Journal Title

      Clin Nephrol. 64(5)

      Pages: 329-336

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma.2005

    • Author(s)
      Nagatsuka H, Naito I, et al.
    • Journal Title

      Virchows Arch. 447(4)(Epub 2005 Oct 19.)

      Pages: 710-716

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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