Effect of autoantihody from myasthenia gravis and immunosuppressant on gene expression of skeletal muscle

• Project/Area Number: 16590818
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kanazawa University
• Principal Investigator: YOSHIKAWA Hiroaki Kanazawa University, Health Service Center, Professor (10272981)
• Co-Investigator(Kenkyū-buntansha): IWASA Kazuo Kanazawa University, Graduate of School of Medicine, Associate Professor (10345613)
• Project Period (FY): 2004 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,600,000); Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: Myasthenia gravis / Thymus / Thymoma / Interleukin -12 / Autoantihndies / 抗サイトカイン抗体 / IL-12 p40 / IL-12 p70 / IL-12p40 / IL-12p70 / アセチルコリン受容体 / 細胞内カルシウム / リアノジン受容体 / IP3受容体 / FK506 / 横紋筋 / 平滑筋

Research Abstract

Myasthenia gravis (MG) is thought to be a disorder targeting at the acetylcholine receptor (AChR) on postsynaptic membrane of neuromuscular junction (NMJ). One of clinical characteristics of MG is high prevalence of thymic abnormality as high as 90% of patients. About 80% of patients have thymic follicular hyperplasia and 20% have thymoma. The patients with thymoma are refractory to therapy, i.e., they need to receive high amount of steroid for treatment. We measured AChR antibody, cytokines and antibodies against cytokines for studying the autoimmunity of MG patients with thymoma. For measurement of AChR antibodies, we used immunoprecipitation method. For measurement of cytokines, enzyme-linked immunosorbent assay (ELISA) was applied. For measurement of antibodies against cytokines, the modified ELISA was utilized. As a result, antibodies against interleukin (IL)-12 p70 were high in patients with thymoma with or without MG. IL-12 p40 and anti-IL-12 p40 antibodies elevated in sera from MG patients with thymoma. Additionally, we developed assay system for detecting antibodies against ryanodine receptor (RyR) that have a role in excitation-contraction (E-C) coupling of skeletal muscle. The method use whole protein of RyR instead to synthetic peptide, and is more sensitive and specific than ELISA system using synthetic peptide. Using detection system for RyR antibodies, we found that a group of MG patients with thymoma have autoantibodies against both AChR and RyR. Therefore, the pathological targets of MG patients with thymoma are synaptic transmission (AChR) and E-C coupling (RyR).

Research Products

• [Journal Article] A novel immunomodulator, FTY720, prevents development of experimental autoi mmune myasthenia gravis in C57BL/6 mice.□ (2008)
  • Author(s): Takeyuki Kohno, et. al.
  • Journal Title: Mol Pharm Bull 28 Pages: 736-739
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clinical efficacy and cytokine network-modulating effects of tacrolimus in myasthenia gravis. (2008)
  • Author(s): Yutaka Furukawa, et. al.
  • Journal Title: J Neuroimmunol 195 Pages: 108-115
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clinical efficacy and cytokine network-modulating effects of tacrolimus in myasthenia gravis (2008)
  • Author(s): Furukawa, Y., Yoshikawa, H., lwasa, K., Yamada, M
  • Journal Title: J Neuroimmunol 195 Pages: 108-15
  • NAID: 120001135293
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Is excitation-contraction coupling impaired in myasthenia gravis? (2007)
  • Author(s): Miho Nakata, et. al.
  • Journal Title: Clin Neurophysiol 118 Pages: 1144-1148
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Autoantibodies against M1 muscarinic acetylcholine receptor in myasthenic syndrome□. (2007)
  • Author(s): Masaharu Takamori, et. al.
  • Journal Title: Eur J Neurol 14 Pages: 1230-1235
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Long-term effect of intravenous immunoglobulin on anti-MuSK antibody-positive myasthenia gravis. (2007)
  • Author(s): Shibata-Hamaguchi, et. al.
  • Journal Title: Acta Neurol Scand 116 Pages: 406-408
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 国際プロジェクトについて -MGTX Study- (2007)
  • Author(s): 吉川弘明
  • Journal Title: 臨床神経学 47 Pages: 880-881
  • NAID: 10020102808
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Is excitation-contraction coupling impaired in myasthenia gravis (2007)
  • Author(s): Nakata, M., Kuwabara, S., Kawaguchi, N., Takahashi, H., Misawa, S., Kanai, K., Tamura, N., Sawai, S., Motomura, M., Shiraishi, H., Takamori, M., Maruta, T., Yoshikawa, H., Hattori, T
  • Journal Title: Clin Neurophysiol 118 Pages: 1144-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Autoantibodies against MI muscarinic acetylcholine receptor in myasthenic syndrome (2007)
  • Author(s): Takamori, M., Motomura, M., Fukudome, T., Yoshikawa, H
  • Journal Title: Eur J Neurol 14 Pages: 1230-5
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Long-term effect of intravenous immunoglobulin on anti-MuSK antibody-positive myasthenia gravis (2007)
  • Author(s): Shibata-Hamaguchi, A., Samuraki, M., Furui, E., Iwasa, K., Yoshikawa, H., Hayashi, S., Yamada, M
  • Journal Title: Acta Neurol Scand 116 Pages: 406-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Is excitation-contraction coupling impaired in myasthenia gravis (2007)
  • Author(s): Miho Nakata
  • Journal Title: Clinical Neurophysiology 118・5 Pages: 1144-1148
• [Journal Article] Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma.□ (2006)
  • Author(s): Hiroaki Yoshikawa, et. al.
  • Journal Title: J Neuroimmunol 175 Pages: 169-175
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica associated with myasthenia gravis: characteristic phenotype in Japanese population. (2006)
  • Author(s): Yutaka Furukawa, et. al.
  • Journal Title: Eur J Neurol 13 Pages: 655-658
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction. (2006)
  • Author(s): Sean J Pttock, et. al.
  • Journal Title: Mayo Clin Proc 81 Pages: 1207-1214
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Current status and future direction of therapy for myasthenia gravis in Japan. (2006)
  • Author(s): Hiroaki Yoshikawa
  • Journal Title: Neuro-Ophthalmology 30 Pages: 45-45
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma (2006)
  • Author(s): Yoshikawa, H., Sato, K., Edahiro, S., Furukawa, Y., Maruta, T., Iwasa, K., Watanabe, H., Takaoka, S., Suzuki, Y., Takamori, M., Yamada, M
  • Journal Title: J Neuroimmunol 175 Pages: 169-75
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuromyelitis optica associated with myasthenia gravis : characteristic phenotype in Japanese population. E (2006)
  • Author(s): Furukawa, Y., Yoshikawa, H., Yachie, A., Yamada, M
  • Journal Title: Eur J Neurol 13 Pages: 655-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction (2006)
  • Author(s): Pittrock, SJ., Yoshikawa, H., Ahlskog, JE., Tisch, SH., Benarroch, EE., Kryzer, TJ., Lennon, VA
  • Journal Title: Mayo Clin Proc 81 Pages: 1207-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma (2006)
  • Author(s): Hiroaki Yoshikawa
  • Journal Title: Journal of Neuroimmunology 175・1-2 Pages: 169-175
• [Journal Article] Neuromyelitis optica associated with myasthenia gravia : characteristic phenotype in Japanese population (2006)
  • Author(s): Yutaka Furukawa
  • Journal Title: European Journal of Neurology 13・6 Pages: 655-658
• [Journal Article] Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction (2006)
  • Author(s): Sean J.Pittock
  • Journal Title: Mayo Clinic Proceedings 81・9 Pages: 1207-1214
• [Journal Article] Current status and future direction of therapy for myasthenia gravis in Japan(Abstract) (2006)
  • Author(s): Hiroaki Yoshikawa
  • Journal Title: Neuro-Ophthalmology 30 Pages: 48-48
• [Journal Article] Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma. (2006)
  • Author(s): Hiroaki Yoshikawa, Katsuaki Sato, Shigeki Edahiro, Yutaka Furukawa, Takahiro Maruta, Kazuo Iwasa, Hideto Watanabe, Shizuka Takaoka, Yasuhiro Suzuki, Masaharu Takamori, Masahito Yamada
  • Journal Title: Journal of Neuroimmunology (in press)
• [Journal Article] A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice. (2006)
  • Author(s): Kohno T, Isuji T, Hirayama K, Iwatsuki R, Hirose M, Watabe K, Yoshikawa H, Kohno T, Matsumoto A, Fujita T, Hayashi M.
  • Journal Title: Mol Pharm Bull 28 Pages: 736-739
• [Journal Article] Neuromyelitis Optica Associated with Myasthenia Gravis : Characteristic phenotype in Japanese population. (2006)
  • Author(s): Furukawa Y, Yoshikawa H, Yachie A, Yamada M.
  • Journal Title: Eur J Neurol (in press)
• [Journal Article] 重症筋無力症の病態 病因と発症のメカニズム (2005)
  • Author(s): 吉川弘明
  • Journal Title: Clinical Neuroscience 23 Pages: 388-391
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 重症筋無力症の治療 (2005)
  • Author(s): 吉川弘明
  • Journal Title: 神経眼科 22 Pages: 336-346
  • NAID: 10018960388
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice (2005)
  • Author(s): Kohno, T., Tsuji, T., Hirayama, K., Iwatsuki, R., Hirose, M., Watabe, K., Yoshikawa, H., Kohno, T., Matsumoto, A., Fujita, T., Hayashi, M
  • Journal Title: Mol Pharm Bull 28 Pages: 736-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 重症筋無力症の治潦 (2005)
  • Author(s): 吉川弘明
  • Journal Title: 神経眼科 22 Pages: 336-346
• [Journal Article] A Novel Immunomodulator, FTY720, Prevents Development of Experimental Autoimmune Myasthenia Gravis in C57BL/6 Mice (2005)
  • Author(s): Kohno T, Yoshikawa H, et al.
  • Journal Title: Biological Pharmaceutical Bulletin (In press)
• [Journal Article] Cytosolic Ca^<2+> alteration mediates both ryanodine receptor and IP3 receptor in TE671/RD cells. (2004)
  • Author(s): Shigeki Edahiro, et. al.
  • Journal Title: Biomedical Research 25 Pages: 255-261
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Comparative study of pre-operative thymic imaging and pathology in patients with myasthenia gravis. (2004)
  • Author(s): Yoshihiro Yasukawa, et. al.
  • Journal Title: □J Clin Neurosci 11 Pages: 610-613
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Anti-ryanodine receptor antibodies and FK506 in myasthenia gravis.□ (2004)
  • Author(s): Masaharu Takamori, et. al.
  • Journal Title: Neurology 62 Pages: 1894-1896
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 重症筋無力症における患者年齢層の変遷と胸腺組織について. (2004)
  • Author(s): 岩佐和夫, 他
  • Journal Title: 神経免疫学 12 Pages: 45-45
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lambert-Eaton症候群 (2004)
  • Author(s): 吉川弘明
  • Journal Title: 脊椎脊髄ジャーナル 17 Pages: 911-915
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 重症筋無力症における免疫療法の現状と展望-tacrolimusを中心に- (2004)
  • Author(s): 吉川弘明
  • Journal Title: 神経治療学 21 Pages: 31-40
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 重症筋無力症に対する新規免疫抑制剤FTY720の薬効・薬理試験:EAMGマウスを用いた検討 (2004)
  • Author(s): 河野武幸, 他
  • Journal Title: 神経免疫学 12 Pages: 45-45
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 重症筋無力症における患者年齢層の変遷と胸腺組織について (2004)
  • Author(s): 岩佐和夫, 他
  • Journal Title: 神経免疫学 12 Pages: 45-45
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cytosolic Ca^2+ alteration mediates both ryanodine receptor and IP3 receptor in TE671/RD cells (2004)
  • Author(s): Edahiro, S., Yoshikawa, H., Iwasa, K., Hashii, M., Yamada, M
  • Journal Title: Biomedical Research 25 Pages: 255-61
  • NAID: 130004903682
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative study of pre-operative thymic imaging and pathology in patients with myasthenia gravis (2004)
  • Author(s): Yasukawa, Y., Yoshikawa, H., Iwasa, K., Yamada, M., Takamori, M
  • Journal Title: J Clin Neurosci 11 Pages: 610-613
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anti-ryanodine receptor antibodies and FK506 in myasthenia gravis (2004)
  • Author(s): Takamori, M., Motomura, M., Kawaguchi, N., Nemoto, Y., Hattori, T., Yoshikawa, H., Otsuka, K
  • Journal Title: Neurology 62 Pages: 1894-1896
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cytosolic Ca^<2+> alteration mediates both ryanodine receptor and IP_3 receptor in TE671/RD cells. (2004)
  • Author(s): Edahiro S, Yoshikawa H, et al.
  • Journal Title: Biomed Res 25 Pages: 255-261
• [Journal Article] Comparative study of pre-operative thymic imaging and pathology in patients with myasthenia gravis. (2004)
  • Author(s): Yasukawa Y, Yoshikawa H
  • Journal Title: J Clin Neurosci 11・6 Pages: 610-613
• [Journal Article] Anti-ryanodine receptor antibodies and FK506 in myasthenia gravis. (2004)
  • Author(s): Takamori M, Yoshikawa H, et al.
  • Journal Title: Neurology 62・10 Pages: 1894-1896
• [Journal Article] 重症筋無力症における患者年齢層の変遷と胸腺組織について (2004)
  • Author(s): 岩佐和夫, 古川 浩, 吉川弘明, 山田正仁
  • Journal Title: 神経免疫学 12 Pages: 45-45
• [Presentation] 重症筋無力症の疫学調査 -治療の現状を中心に- (2007)
  • Author(s): 吉川弘明, 他
  • Organizer: 第48回日本神経学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 重症筋無力症重症筋無力症の抗リアノジン受容体抗体におけるIgG subclass解析 (2007)
  • Author(s): 丸田高広, 他
  • Organizer: 第48回日本神経学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 重症筋無力症における新規バイオマーカー:抗骨格筋ジヒドロピリジン受容体抗体の検出 (2007)
  • Author(s): 丸田高広, 他
  • Organizer: 第19回日本神経免疫学会
  • Place of Presentation: 金沢
  • Year and Date: 2007-04-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Current Status and Future Direction of Therapy for MG in Japan(Keynote Lecture) (2006)
  • Author(s): Hiroaki Yoshikawa
  • Organizer: XVI International Neuro-ophthalmology Society Meeting
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2006-11-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IL-12 p40 and its antibody are specific marker for myasthenia gravis with thymoma. Comparative study with IL-12 p70 antibody and ryanodine receptor antibody. New Treatment Strategy of Myasthenia Gravis-Basic researches and Clinical experiences of Tacrolimus in Japan- (2006)
  • Author(s): Hiroaki Yoshikawa
  • Organizer: The 8th International Congress of Neuroimmunology Evening Seminar
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2006-10-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IL-12 p40 and its antibody are specific marker for myasthenia gravis with thymoma. Comparative study with IL-12 p70 antibody and ryanodine receptor antibody. New Treatment Strategy of Myasthenia Gravis Basic researches and Clinical experiences of Tacrolimus in Japan- (2006)
  • Author(s): Yoshikawa, H
  • Organizer: The 8th International Congress of Neuroimmunology Evening Seminar
  • Place of Presentation: Nagoya
  • Year and Date: 2006-10-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 重症筋無力症におけるサイトカインと抗サイトカイン抗体に関する研究 (2006)
  • Author(s): 吉川弘明, 他
  • Organizer: 第47回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 重症筋無力症におけるシェーグレン症候群の合併 (2006)
  • Author(s): 加藤裕子, 他
  • Organizer: 第47回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 重症筋無力症における変性型抗アセチルコリン受容体抗体 (2006)
  • Author(s): 岩佐和夫, 他
  • Organizer: 第47回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 重症筋無力症におけるタクロリムスの長期使用に関する研究 (2006)
  • Author(s): 古川 裕, 他
  • Organizer: 第47回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 特定疾患臨床調査個人票データベースによる重症筋無力症の疫学的研究 (2006)
  • Author(s): 吉川弘明
  • Organizer: 第18回日本神経免疫学会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-03-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Sandwich ELISA法による骨格筋リアノジン受容体抗体定量に関する研究 (2006)
  • Author(s): 丸田高広, 他
  • Organizer: 第18回日本神経免疫学会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-03-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 重症筋無力症末梢血単核球のサイトカイン産生に対する免疫抑制薬の影響 (2006)
  • Author(s): 古川 裕, 他
  • Organizer: 第18回日本神経免疫学会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-03-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Current Status and Future Direction of Therapy for MG in Japan (Keynote Lecture) (2006)
  • Author(s): Yoshikawa, H
  • Organizer: XVI International Neuro-ophthalmology Society Meeting
  • Place of Presentation: Tokyo
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 重症筋無力症IgGが骨格筋培養細胞の遺伝子発現に及ぼす影響 (2005)
  • Author(s): 吉川弘明, 他
  • Organizer: 第46回日本神経学会総会
  • Place of Presentation: 鹿児島
  • Year and Date: 2005-05-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Efficacy of a Novel Immunosuppressant FTY720 as a New Drug for Myasthenia Gravis (2004)
  • Author(s): Takeyuki Kohno, et. al.
  • Organizer: 7th International Congress of Neuroimmunology
  • Place of Presentation: Venice, Italy
  • Year and Date: 2004-10-01
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 重症筋無力症.金澤一郎、河原仁志(編) 誰にでもわかる神経筋疾患119番 (2007)
  • Author(s): 吉川弘明
  • Total Pages: 11
  • Publisher: 日本プランニングセンター
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 全身型重症筋無力症に術前ステロイド治療を行うポイントは.岡本幸市、棚橋紀夫、水澤英洋(編) EBM神経疾患の治療2007-2008 (2007)
  • Author(s): 吉川弘明
  • Total Pages: 4
  • Publisher: 中外医学社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 重症筋無力症.奈良信雄(編) 疾患からまとめた病態生理FIRST AID (2007)
  • Author(s): 吉川弘明、山田正仁
  • Total Pages: 3
  • Publisher: メディカル・サイエンス・インターナショナル
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 周期性四肢麻痺.奈良信雄(編) 疾患からまとめた病態生理FIRST AID (2007)
  • Author(s): 吉川弘明、山田正仁
  • Total Pages: 3
  • Publisher: メディカル・サイエンス・インターナショナル
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 重症筋無力症(分担) 誰にでもわかる神経筋疾患119番 (2006)
  • Author(s): 吉川 弘明
  • Total Pages: 11
  • Publisher: 日本プランニングセンター
• [Book] 重症筋無力症 神経筋疾患診療119番 (2005)
  • Author(s): 吉川弘明
  • Publisher: 日本プランニングセンター(In press)
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://hsc.ad.kanazawa-u.ac.jp/an/
• [Patent(Industrial Property Rights)] ジヒドロピリジン受容体抗体レベルに基づく胸腺腫合併重症筋無力症の診断方法 (2007)
  • Inventor(s): 吉川弘明、丸田高広
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2007-264623
  • Filing Date: 2007-10-10
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 胸腺腫合併重症筋無力症の診断方法 (2006)
  • Inventor(s): 吉川弘明、岩佐和夫、山田正仁
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2006-211045
  • Filing Date: 2006-08-02
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 胸腺腫合併重症筋無力症の診断方法 (2006)
  • Inventor(s): 吉川弘明, 岩佐和夫, 山田正仁
  • Industrial Property Rights Holder: 同左
  • Industrial Property Number: 2006-211045
  • Filing Date: 2006-08-02