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Basic studies for neurophysiological approaches to sensory processing in elderly people and patients with dementia.

Research Project

Project/Area Number 16590821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

HOSHIYAMA Minoru  Nagoya University, School of Medicine, Professor, 医学部, 教授 (30270482)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordssensory processing / memory / clinical neurophysiology / higher brain function / cognition / sensory motor integration / 感覚運動連関 / 大脳誘発誘発電位 / サブリミナル / ヒト / 時間識別覚
Research Abstract

The present studies investigated neurophysiological and neuropathological aspect of aging and dementia related disorders, using non-invasive techniques. The methods I used included elecroencephalography, evoked brain potentials, magnetoencephalography and transcranial magnetic stimulation. I clarified the aging change of temporal discrimination, which is one of the fundamental sensory processes for sensation (Hoshiyama et al. Muscle & Nerve, 2004). Many evidences concerning somatosensory and cognitive function were clarified. In 2005, I developed a new technique to investigate visual processes, using very short presentation time, and investigated neurophysiological (Hoshiyama et al. Human Brain Mapping, in press) and psychological (Hoshiyama et al. Neuroscience Letters) neural processes of visual memory. Circadian change of cognitive function in demented people has been also investigated (Uemura and Hoshiyama, in submission). From the results of the studies, temporal processing of sensory signal was an important factor, and it was disturbed in the elderly people, which could be related to the memory and cognitive dysfunction.
It was considered that the results of the studies provided the possibility of neurophysiological approach to various neurological disorders, which would give us real-time information of neural function of the patients.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (17 results)

All 2006 2005 2004

All Journal Article (17 results)

  • [Journal Article] Priority of face perception during subliminal stimulation using a new color-opponent flicker stimulation.2006

    • Author(s)
      Hoshiyama M, Kakigi R, Takeshima Y, Miki K, Watanabe S.
    • Journal Title

      Neuroscience Letters 402

      Pages: 57-61

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential priming effects of color-opponent subliminal stimulation on visual magnetic responses.2006

    • Author(s)
      Hoshiyama M, Kakigi R, Miki K, Watanabe S, Takeshima Y.
    • Journal Title

      Human Brain Mapping (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Priority of face perception during subliminal stimulation using a new color-opponent flicker stimulation.2006

    • Author(s)
      Hoshiyama M, Kakigi R, Takeshima Y, Miki K, Watanabe S.
    • Journal Title

      Neuroscience Letters 402(1-2)

      Pages: 57-61

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential priming effects of color-opponent subliminal stimulation on visual magnetic responses.2006

    • Author(s)
      Hoshiyama M, Kakigi R, Miki K, Watanabe S, Takeshima Y.
    • Journal Title

      Human Brain Mapping (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional relationship between human rolandic oscillations and motor cortical excitability : an MEG study.2005

    • Author(s)
      Tamura Y, Hoshiyama M, Nakata H, Hiroe N, Inui K, Kaneoka Y, Inoue K, Kakigi R.
    • Journal Title

      European Journal of Neuroscience 21

      Pages: 2555-2562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional relationship between human rolandic oscillations and motor cortical excitability : an MEG study.2005

    • Author(s)
      Tamura Y, Hoshiyama M, Nakata H, Hiroe N, Inui K, Kaneoke Y, Inoue K, Kakigi R.
    • Journal Title

      European Journal of Neuroscience 21(9)

      Pages: 2555-2562

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional relationship between human rolandic oscillations and motor cortical excitability : an MEG study.2005

    • Author(s)
      Tamura Y, Hoshiyama M, Nakata H, Hiroe N, Inui K, Kaneoke Y, Inoue K, Kakigi R.
    • Journal Title

      European Journal of Neuroscience 21

      Pages: 2555-2562

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Temporal discrimination threshold on various parts of the body.2004

    • Author(s)
      Hoshiyama M, Kakigi R, Tamura Y.
    • Journal Title

      Muscle & Nerve 29

      Pages: 243-247

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cognitive processes in two-point discrimination : an ERP study.2004

    • Author(s)
      Tamura Y, Hoshiyama M, Inui K, Nakata H, Wasaka T, Ojima S, Inoue K, Kakigi R.
    • Journal Title

      Clinical Neurophysiology 115 115

      Pages: 1875-1884

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Temporal discrimination threshold on various parts of the body.2004

    • Author(s)
      Hoshiyama M, Kakigi R, Tamura Y.
    • Journal Title

      Muscle & Nerve 29(2)

      Pages: 243-247

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cognitive processes in two-point discrimination : an ERP study.2004

    • Author(s)
      Tamura Y, Hoshiyama M, Inui K, Nakata H, Wasaka T, Ojima S, Inoue K, Kakigi R.
    • Journal Title

      Clinical Neurophysiology 115(8)

      Pages: 1875-1884

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Temporal discrimination threshold on various parts of the body.2004

    • Author(s)
      Hoshiyama M, Kakigi R, Tamura Y
    • Journal Title

      Muscle & Nerve 29

      Pages: 243-247

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Facilitation of A[delta]-fiber-mediated acute pain by repetitive transcranial magnetic stimulation.2004

    • Author(s)
      Tamura Y, Hoshiyama M, et al.
    • Journal Title

      Neurology 62

      Pages: 2176-2181

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cognitive processes in two-point discrimination : ERP study2004

    • Author(s)
      Tamura Y, Hoshiyama M, et al.
    • Journal Title

      Clinical Neurophysiology 115

      Pages: 1875-1884

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Face representation in the human primary somatosensory cortex.2004

    • Author(s)
      Nguyen BT, Tran TD, Hoshiyama M, et al.
    • Journal Title

      Neuroscience Research 50

      Pages: 227-232

    • NAID

      10014233804

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 正中神経刺激による体性感覚誘発電位もRecovery function-短時間 Interstimulus intervalの検討-2004

    • Author(s)
      宝珠山稔, 柿木隆介
    • Journal Title

      臨床脳波 46

      Pages: 424-429

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 調音をともなう発声時のヒト脳磁場反応2004

    • Author(s)
      軍司敦子, 柿木隆介, 宝珠山稔
    • Journal Title

      臨床脳波 46

      Pages: 487-491

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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