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Development of the noninvasive brain function diagnostic procedure using magnetoencephalography for the purpose of foreseeing the onset of cerebral ischemia

Research Project

Project/Area Number 16590842
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionOsaka City University

Principal Investigator

TSUYUGUCHI Naohiro  Osaka City University, Graduate School of Medicine, Lecturer, 大学院医学研究科, 講師 (50295705)

Co-Investigator(Kenkyū-buntansha) TSUTADA Tsuyoshi  Osaka City University, Graduate School of Medicine, Lecturer, 大学院医学研究科, 講師 (10188550)
TAKAMI Toshihiro  Osaka City University, Graduate School of Medicine, Lecturer, 大学院医学研究科, 講師 (20305626)
ADACHI Yoshiaki  Kanazawa Institute of Technology, Applied Electronic Laboratory, Research associate, 先端電子技術応用研究所, 助手 (80308585)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordspositron emission tomography / magnetoencephalography / cerebral infarction / micro SQUID / micro PET / 脳梗塞 / microPET / micro SQUID / evoked potential / micro PET / evoked field
Research Abstract

Clinical researches of MEG and PET
We performed 015 gas PET, which measured cerebral blood flow(CBF) and oxygen extraction fraction(OEF), and magnetoencephalography which measured evoked magnetic field for cerebrovascular disorder 25 examples. Furthermore, we measured spontaneous magnetic field of brain and analyzed the frequency using spatial filter technique(beam former). The results showed correlation of dipole moment of N20m and OEF. Beam former showed 0 and 6 activity in the ischemic area. Especialy, 0 activity correlated OEF increased lesion.
Fundamental researches of MEG
We developed SQUID magneto meter array of nine channels which did integration on a silicon chip for the purpose of small animal's magnetic field. (the sensor array have nine 2.5mm (I) SQUID magneto meters arranged in the shape of 3 X 3 matrices every 2.75mm, and total size is 10 X 10mm.). We set this magnetometor in small shield box which set in a shield room. We could reproducibility measure visual evoked field and auditory evoked field of rat brain using this instrument, but could not detect somatosensory evoked field.
Fundamental researches of PET
We made a cerebral ischemia model of rat brain and measured carbohydrate metabolism using micro PET. We compared PET image with autoradiograph in small ischemic area of middle cerebral artery, and PET could enough detect its lesion. We measured brain glucose metabolism by electric stimulation of peripheral nerve, but were not able to detect clear change. However, the lesion was depicted in autoradiograph distinctly. It is thought that there is limitation for analysis of rat brain in micro PET with an aspect of quantitative evaluation..

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (15 results)

All 2006 2005 2004

All Journal Article (15 results)

  • [Journal Article] Measurement of Spinal Cord Evoked Fields by Vector SQUID. Biomagnetometer2006

    • Author(s)
      Adachi Y
    • Journal Title

      Biomagnetometer, Electrical Engineering in Japan 157

      Pages: 15-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ベクトルSQUID磁束計による脊髄誘発磁場計測2006

    • Author(s)
      足立善昭
    • Journal Title

      電気学会論文誌 125・2

      Pages: 85-91

    • NAID

      10014302445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 小動物用小型生体磁気計測システムの開発2006

    • Author(s)
      宮本政和
    • Journal Title

      信学技報 IEICE Technical Report SCE2006

      Pages: 31-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Measurement of Spinal Cord Evoked Fields by Vector SQUID.2006

    • Author(s)
      Adachi Y, Miyamoto M, Kawai J, Uehara G.
    • Journal Title

      Biomagnetometer, Electrical Engineering in Japan 157

      Pages: 15-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A Low Noise SQUID Magnetometer Array Probe Designed for Mouse and Rat MCG Measurements.2006

    • Author(s)
      Kawai J, Kawabata M, Shimozu T, Miyamoto M, Adachi Y, Uehara G, Komamura K, Tsuyuguchi N.
    • Journal Title

      Biomag2006/ 15th International conference on biomagnetism

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development of a Biomagnetism Measurement System for Smal Animals.2006

    • Author(s)
      Miyamoto M, Kawai J, Kawabata M, Shimozu T, Adachi Y, Uehara G, Komamura K, Tsuyuguchi N, Haruta Y.
    • Journal Title

      Biomag2006/ 15th International conference on biomagnetism

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Measurement of Spinal Cord Evoked Magnetic Fields by Vector SQUID Biomagnetmeter2006

    • Author(s)
      Yoshiaki Adachi, Masakazu Miyamoto, Jun Kawai, Gen Uehara
    • Journal Title

      Electrical Engineering in Japan 157・2

      Pages: 85-91

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fabrication and Characterization of an Integrated 9-Channel Superconducting Quantum Interference Device Magnetometer Array2005

    • Author(s)
      Kawai J
    • Journal Title

      IEEE Transactions on Applied Superconductivity 15

      Pages: 821-824

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A. 30-channel SQUID vector biomagnetometer system optimized for reclining subjects2005

    • Author(s)
      Adachi Y
    • Journal Title

      IEEE Tran Applied Superconductivity 15

      Pages: 672-675

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A SQUID biomagnetometer system for measurement of a human cervical spinal cord evoked field. Superconductor Science and Technolog2005

    • Author(s)
      Adachi Y
    • Journal Title

      Superconductor Science and Technology 18

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Fabrication and Characterization of an Integrated 9-Channel Superconducting Quantum Interference Device Magnetometer Array.2005

    • Author(s)
      Kawai J, Shimozu T, Kawabata M, Uehara G, Adachi Y, Miyamoto M, Ogata H.
    • Journal Title

      IEEE Transactions on Applied Superconductivity 15

      Pages: 821-824

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A 30-channel SQUID vector biomagnetometer system optimized for reclining subjects.2005

    • Author(s)
      Adachi Kawai J, Uehara G, Fukuoka Y, Miyamoto M, Komori H, Ubo H, Kawabata S.
    • Journal Title

      IEEE Tran Applied Superconductivity 15

      Pages: 672-675

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A SQUID biomagnetometer system for measurement of a human cervical spinal cord evoked field.2005

    • Author(s)
      Adachi Y, Kawai J, Uehara G, Miyamoto M, Kawabata S, Ogata H, Tomizawa S.
    • Journal Title

      Superconductor Science and Technology 18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evolution of diaschisis in a focal stroke model2004

    • Author(s)
      Carmicliael ST
    • Journal Title

      Stroke 35

      Pages: 758-763

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evolution of diaschisis in a focal stroke model.2004

    • Author(s)
      Carmichael ST, Tatsukawa K, Katsman D, Tsuyuguchi N, Kornblum HI.
    • Journal Title

      Stroke 35

      Pages: 758-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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