Development of the noninvasive brain function diagnostic procedure using magnetoencephalography for the purpose of foreseeing the onset of cerebral ischemia
| Project/Area Number |
16590842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Osaka City University |
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Principal Investigator |
TSUYUGUCHI Naohiro Osaka City University, Graduate School of Medicine, Lecturer, 大学院医学研究科, 講師 (50295705)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTADA Tsuyoshi Osaka City University, Graduate School of Medicine, Lecturer, 大学院医学研究科, 講師 (10188550)
TAKAMI Toshihiro Osaka City University, Graduate School of Medicine, Lecturer, 大学院医学研究科, 講師 (20305626)
ADACHI Yoshiaki Kanazawa Institute of Technology, Applied Electronic Laboratory, Research associate, 先端電子技術応用研究所, 助手 (80308585)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | positron emission tomography / magnetoencephalography / cerebral infarction / micro SQUID / micro PET / 脳梗塞 / microPET / micro SQUID / evoked potential / micro PET / evoked field |
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| Research Abstract |
Clinical researches of MEG and PET
We performed 015 gas PET, which measured cerebral blood flow(CBF) and oxygen extraction fraction(OEF), and magnetoencephalography which measured evoked magnetic field for cerebrovascular disorder 25 examples. Furthermore, we measured spontaneous magnetic field of brain and analyzed the frequency using spatial filter technique(beam former). The results showed correlation of dipole moment of N20m and OEF. Beam former showed 0 and 6 activity in the ischemic area. Especialy, 0 activity correlated OEF increased lesion.
Fundamental researches of MEG
We developed SQUID magneto meter array of nine channels which did integration on a silicon chip for the purpose of small animal's magnetic field. (the sensor array have nine 2.5mm (I) SQUID magneto meters arranged in the shape of 3 X 3 matrices every 2.75mm, and total size is 10 X 10mm.). We set this magnetometor in small shield box which set in a shield room. We could reproducibility measure visual evoked field and auditory evoked field of rat brain using this instrument, but could not detect somatosensory evoked field.
Fundamental researches of PET
We made a cerebral ischemia model of rat brain and measured carbohydrate metabolism using micro PET. We compared PET image with autoradiograph in small ischemic area of middle cerebral artery, and PET could enough detect its lesion. We measured brain glucose metabolism by electric stimulation of peripheral nerve, but were not able to detect clear change. However, the lesion was depicted in autoradiograph distinctly. It is thought that there is limitation for analysis of rat brain in micro PET with an aspect of quantitative evaluation..
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Report
(4 results)
Research Products
(15 results)
