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Antithrombotic therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome

Research Project

Project/Area Number 16590849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionTokai University

Principal Investigator

KITAGAWA Yasuhisa  Tokai University, School of Medicine, Assistant Professor, 医学部, 教授 (30124944)

Co-Investigator(Kenkyū-buntansha) KAMETSU Yutaka  Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (30233977)
SEKIYAMA Sari  Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (40276811)
OKUMA Naohiro  Tokai University, School of Medicine, Assistant Professor, 医学部, 講師 (50307005)
松田 博  東海大学, 医学部, 助手 (20317811)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordsantiphospholipid antibody / stroke / anticoagulation therapy / antiplatelet therapy / secondary prevention / anticardiolipin antibody / lupus anticoagulant / Activated plate / 抗リン脂質抗体症候群 / スタチン
Research Abstract

Antiphospholipid antibody was considered to be a risk factor for ischemic stroke. Among the various antiphospholipid antibodies, β2-GPI dependent anticardiolipin antibody and lupus anticoagulant were important. We examined the incidence of these antibodies in 250 ischemic stroke patients. β2-GPI dependent anticardiolipin antibody was 2.8% and lupus anticoagulant was 9.2%. Antithrombotic therapy for secondary prevention of ischemic stroke in patients with antiphospholipid syndrome (APS) remains controversial. We therefore compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with APS
The subjects were 20 ischemic stroke patients with antiphosholipid antibody (10 males and 10 females, mean age 48 years), 13 with primary antiphospholipid syndrome and 7 with SLE-related antiphospholipid syndrome. Diagnosis of APS was based on the 1998 Sapporo Criteria. Patients ware assigned to either single an … More tiplatelet therapy (aspirin 100 mg or ticlopidine 200 mg) or a combination of antiplatelet and anticoagulation therapy (INR : 2.0-3.0 ; mean 2.4±0.3) for the secondary prevention of stroke. There was no significant difference between the two groups in age, gender, NIHSS on admission, mRS at discharge, or rates of hypertension, diabetes mellitus, hyperlipidemia, and cardiac disease. We examined the Kaplan-Meier survival curves in each treatment. The primary outcome was the occurrence of stroke. The mean follow-up time was 3.9±2.0 years. The cumulative incidence of stroke in patients with single antiplatelet treatment was statistically significantly higher than that in patients receiving the combination of antiplatelet and anticoaglation therapy (log-rank test, p-value=0.026). The incidence of hemorrhagic complications was similar in the two groups. The recent APASS study did not show any difference in effectiveness for secondary prevention between single antiplatelet (aspirin) and single anticoagulant (warfarin) therapy. Our results indicate that combination therapy may be more effective in APS-related ischemic stroke. Less

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (13 results)

All 2006 2005 Other

All Journal Article (13 results)

  • [Journal Article] 抗リン脂質抗体症候群2006

    • Author(s)
      北川 泰久
    • Journal Title

      日本臨床 64巻7

      Pages: 196-203

    • NAID

      10016918471

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Prevalence rates of antiphospholipid antibodies in ischemic Stroke patients2006

    • Author(s)
      Okuma. H
    • Journal Title

      Intern Med 45

      Pages: 1017-1018

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 抗リン脂質抗体症候群における脳梗塞の活性化血小板に関する検討2006

    • Author(s)
      石川 達也
    • Journal Title

      第47回日本神経学会総会抄録集

      Pages: 241-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 抗リン脂質抗体陽性脳梗塞に対する抗血栓療法に関する検討2006

    • Author(s)
      北川 泰久
    • Journal Title

      神経治療学 23巻3号

      Pages: 255-255

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antiphospolipid syndrome2006

    • Author(s)
      Kitagawa.Y
    • Journal Title

      Nihon Rinsho 64

      Pages: 196-203

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prevalence rates of antiphospholipid antibodies in ischemic stroke patients2006

    • Author(s)
      Okuma.H
    • Journal Title

      Intern Med 45

      Pages: 1017-1018

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antithrombotic therapy for secondary preventions in ischemic stroke patients with APS.2006

    • Author(s)
      Kitagawa Y
    • Journal Title

      Shinkei Chiryo 23

      Pages: 255-255

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prevalence rates of antiphospholipid antibodies in ischemic stroke patients2006

    • Author(s)
      Okuma. H
    • Journal Title

      Intern Med 45

      Pages: 1017-1018

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 若年層における脳血管障害update、抗リン脂質抗体症候群2005

    • Author(s)
      北川泰久
    • Journal Title

      臨床神経 45巻11号

      Pages: 852-855

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 長寿のための脳血管障害の予防と治療-若年者と高齢者における危険因子の意義2005

    • Author(s)
      北川泰久
    • Journal Title

      臨床成人病 35巻7号

      Pages: 776-783

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical diversity of antiphospholipid protein antibodies in ischemic stroke2005

    • Author(s)
      Kitagawa Y, Matsuda H, Sekiyama S, et al.
    • Journal Title

      Journal of Neurological Science 238巻suppl1

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 脳と循環2005

    • Author(s)
      北川泰久
    • Journal Title

      特殊な原因による脳卒中、抗リン脂質抗体症候群 10巻1号

      Pages: 51-56

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activated platelet function in ischemic stroke patients with antiphosplipid syndrome.

    • Author(s)
      Ishikawak.T
    • Journal Title

      Abstract of 47^<th>Japanese Congress of Neurology

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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