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Magnetic measurements of human cerebellar activity- noninvasive study of cerebro-cerebellar interaction

Research Project

Project/Area Number 16590852
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKANAZAWA INSTITUTE OF TECHNOLOGY

Principal Investigator

HASHIMOTO Isao  Kanazawa Institute of Technology, Dept.of Engineering, Researcher, 工学部, 研究員 (40250211)

Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordscerebellar activity / magnetic measurements / cerebro-cerebellar interaction
Research Abstract

The aims of this study are to elucidate physiological mechanisms of the four components in cerebellar activity and functional relations between cerebrum and cerebellum by recording magnetic somatosensory and cerebellar activity simultaneously. Specifically, we attempted to define the cerebellar input from periphery, ascending connection from the cerebellum to cerebral cortex and descending input from the cortex to cerebellum. We obtained the following results.
1.Somatotopic representations in the cerebellum
Somatotopic representations in the cerebellum have been well established in animal studies. We examined whether similar representations are present in humans by delivering electric stimuli over 6 points in peripheral nerves of upper and lower limbs and discrete representations are not found. The results suggest that the spatial resolution of MEG is not sufficient for studying somatotopic representations in the human cerebellum.
2.Steady state response from the cerebellum
By delivering rhythmic 8 Hz and 16 Hz stimulation of the median nerve, steady state response from the cerebellum was elicited to 8 Hz stimulus.
3.Source estimation of the cerebellar response by multi-dipole estimation method
We were able to estimate cerebellar sources in only one third of the cases by multi-dipole estimation method. This is due to strong signals from SI which overshadow the cerebellar response and to low signal-to-noise ratio influenced by environmental magnetic noise.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (32 results)

All 2006 2005 2004 Other

All Journal Article (32 results)

  • [Journal Article] 感覚と運動に関連した脳活動の再構成と可視化2006

    • Author(s)
      岩田和浩, 関原謙介, 根本正史, 井口義信, 田中博昭, 橋本勲
    • Journal Title

      東京都立科学技術大学紀要 19

      Pages: 47-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 示指電気刺激と反対側示指トリガー運動に伴う脳活動の空間フィルターによる再構成2006

    • Author(s)
      岩田和浩, 関原謙介, 根本正史, 井口義信, 田中博昭, 橋本勲
    • Journal Title

      日本生体磁気学会誌 特別号 18 No.1

      Pages: 124-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] High frequency oscillatory activities during selective attention in humans2006

    • Author(s)
      Ozaki I, Yaegashi Y, Baba M, Hashimoto I
    • Journal Title

      Electroenceph Gun Neurophysiol Suppl (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 体性感覚野高周波振動の抑制介在ニューロン仮説をめぐって2006

    • Author(s)
      橋本勲
    • Journal Title

      日本生体磁気学会 論文誌 (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High frequency oscillatory activities during selective attention in humans2006

    • Author(s)
      Ozaki I, Yaegashi Y, Baba M Hashimoto I
    • Journal Title

      Electroenceph Clin Neurophysiol Suppl (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 体性感覚野高周波振動の抑制介在ニューロン仮説をめぐって2006

    • Author(s)
      橋本勲
    • Journal Title

      日本生休磁気学会 論文誌 (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neural mechanisms of ultrafast activities2005

    • Author(s)
      Ozaki I, Hashimoto I
    • Journal Title

      Clin EEG Neurosci 36

      Pages: 271-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Attention induces reciprocal activity in human somatosensory cortex enhancing relevant- and suppressing irrelevant inputs Ifrom fingers2005

    • Author(s)
      Iguchi Y, Hoshi Y, Tanosaki M, Taira M, Hashimoto I
    • Journal Title

      Clin Neurophysiol 116

      Pages: 1077-1087

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 注意の焦点の脳内表現 : 選択的注意によるヒト一次体性感覚野の可塑的変化2005

    • Author(s)
      井口義信, 星詳子, 根本正史, 泰羅雅登, 橋本勲
    • Journal Title

      臨床脳波 47

      Pages: 372-277

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Attention induces reciprocal activity in human somatosensory cortex enhancing relevant- and suppressing irrelevant inputs from fingers.2005

    • Author(s)
      Iguchi Y, Hoshi Y, Tanosaki M, Taira M, Hashimoto I
    • Journal Title

      Clin Neurophysiol 116

      Pages: 1077-1087

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Neural mechanisms of ultrafast activities.2005

    • Author(s)
      Ozaki I, Hashimoto I
    • Journal Title

      Clin EEG Neurosci 36

      Pages: 271-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Attention induces reciprocal activity in human somatosensory cortex enhancing relevant- and suppressing irrelevant inputs from fingers2005

    • Author(s)
      Iguchi Y, Hoshi Y, Tanosaki M, Taira M, Hashimoto I
    • Journal Title

      Clin Neurophysiol 116

      Pages: 1077-1087

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 注意の焦点の脳内表現:選択的注意によるヒト一次体性感覚野の可塑的変化2005

    • Author(s)
      井口義信, 星詳子, 根本正史, 泰羅雅登, 橋本勲
    • Journal Title

      臨床脳波 47

      Pages: 372-377

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Is there training-dependent reorganization of digit representations in area 3b of string players?2004

    • Author(s)
      Hashimoto I, Suzuki A, Kimura T, Iguchi Y, et al.
    • Journal Title

      Clin Neurophysiol 115

      Pages: 435-447

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Serial N2Om dipoles in somatosensory evoked magnetic fields move along the distal-proximal representation of the digit in human area 3b.2004

    • Author(s)
      Tonosaki M, Hashimoto I
    • Journal Title

      Neurosci Lett 359

      Pages: 175-179

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rapid change of tonotopic maps in the human auditory cortex during pitch discrimination2004

    • Author(s)
      Ozaki I, Jin CY, Suzuki Y, Baba M, Matsunaga M, Hashimoto I
    • Journal Title

      Clin Neurophysiol 115

      Pages: 1592-1604

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional connectivity between forearm and digits representations in human somatosensory area 3b2004

    • Author(s)
      Tanosaki M, Iguchi Y, Kimura T, Takino R, Hashimoto I
    • Journal Title

      Clin Neurophysiol 115

      Pages: 2638-2644

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Disinhibition of the somatosensory cortex in cervical dystoniae-Decreased amplitudes of high-frequency oscillations2004

    • Author(s)
      Inoue K, Hashimoto I, Kawakami H, Takafumi M, Nakamura S
    • Journal Title

      Clin Neurophysiol 115

      Pages: 1624-1630

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ヒト小脳活動の磁場計測2004

    • Author(s)
      橋本勲, 木村友昭, 鈴木篤志, 田野崎真人, 井口義信, 多喜乃亮介, 根本正史, 早川友恵, 関原謙介
    • Journal Title

      臨床脳波 46

      Pages: 191-198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 単一ダイポール法による脳磁場発生源の推定-移動するダイポールと二つの電流源による見かけのダイポールの移動について-2004

    • Author(s)
      尾崎勇, 橋本勲
    • Journal Title

      Clin Neurophysiol 46

      Pages: 65-71

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Is there training- dependent reorganization of digit representations in area 3b of string players?2004

    • Author(s)
      Hashimoto I, Suzuki A, Kimura T, Iguchi Y, Tanosaki M, Takino R, Haruta Y Taira M
    • Journal Title

      Clin Neurophysiol 115

      Pages: 435-447

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Serial N20m dipoles in somatosensory evoked magnetic fields move along the distal-proximal representation of the digit in human area 3b.2004

    • Author(s)
      Tanosaki M, Hashimoto I
    • Journal Title

      Neurosci Lett 359

      Pages: 175-179

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rapid change of tonotopic maps in the human auditory cortex during pitch discrimination.2004

    • Author(s)
      Ozaki I, Jin CY, Suzuki Y, Baba M, Matsunaga M, Hashimoto I
    • Journal Title

      Clin Neurophysiol 115

      Pages: 1592-1604

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Functional connectivity between forearm and digits representations in human somatosensory area 3b.2004

    • Author(s)
      Tanosaki M, Iguchi Y, Kimura T, Takino R, Hashimoto I
    • Journal Title

      Clin Neurophysiol 115

      Pages: 2638-2644

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Disinhibition of the somatosensory cortex in cervical dystonia- Decreased amplitudes of high-frequency oscillations.2004

    • Author(s)
      noue K, Hashimoto I, Kawakami H, Takafumi M, Nakamura S
    • Journal Title

      Clin Neurophysiol 115

      Pages: 1624-1630

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Serial N20m dipoles in somatosensory evoked magnetic fields move along the distal-proximal representation of the digit in human area 3b.2004

    • Author(s)
      Tanosaki M, Hashimoto I.
    • Journal Title

      Neurosci Lett 359

      Pages: 175-179

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Rapid change of tonotopic maps in the human auditory cortex during pitch discrimination.2004

    • Author(s)
      Ozaki I, Jin CY, Suzuki Y, Baba M, Matsunaga M, Hashimoto I.
    • Journal Title

      Clin Neurophysiol 115

      Pages: 1592-1604

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Functional connectivity between forearm and digits representations in human somatosensory area 3b.2004

    • Author(s)
      Tanosaki M, Iguchi Y, Kimura T, Takino R, Hashimoto I.
    • Journal Title

      Clin Neurophysiol 115

      Pages: 2638-2644

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Disinhibition of the somatosensory cortex in cervical dystonia-Decreased amplitudes of high-frequency oscillations.2004

    • Author(s)
      Inoue K, Hashimoto I, Kawakami H, Takafumi M, Nakamura S.
    • Journal Title

      Clin Neurophysiol 115

      Pages: 1624-1630

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 単一ダイポール法による脳磁場発生源の推定-移動するダイポールと二つの電流源による見かけのダイポールの移動について-。2004

    • Author(s)
      尾崎勇, 橋本勲
    • Journal Title

      Clin Neurophysiol 46

      Pages: 65-71

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Attention induces reciprocak activity in human auditory cortex enhancing relevant-and suppressing irrelevant inputs from fingers.

    • Author(s)
      Iguchi Y, Hoshi Y, Tanosaki M, Taira M, Hashimoto I.
    • Journal Title

      Clin Neurophysiol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Attention induces reciprocal activity in human somatosensory cortex enhancing relevant- and suppressing irrelevant inputs from fingers.

    • Author(s)
      Iguchi Y, Hoshi Y, Tanosaki M, Taira M, Hashimoto I.
    • Journal Title

      Clin Neurophysiol (in press)

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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