Magnetic measurements of human cerebellar activity- noninvasive study of cerebro-cerebellar interaction
| Project/Area Number |
16590852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | KANAZAWA INSTITUTE OF TECHNOLOGY |
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Principal Investigator |
HASHIMOTO Isao Kanazawa Institute of Technology, Dept.of Engineering, Researcher, 工学部, 研究員 (40250211)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | cerebellar activity / magnetic measurements / cerebro-cerebellar interaction |
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| Research Abstract |
The aims of this study are to elucidate physiological mechanisms of the four components in cerebellar activity and functional relations between cerebrum and cerebellum by recording magnetic somatosensory and cerebellar activity simultaneously. Specifically, we attempted to define the cerebellar input from periphery, ascending connection from the cerebellum to cerebral cortex and descending input from the cortex to cerebellum. We obtained the following results.
1.Somatotopic representations in the cerebellum
Somatotopic representations in the cerebellum have been well established in animal studies. We examined whether similar representations are present in humans by delivering electric stimuli over 6 points in peripheral nerves of upper and lower limbs and discrete representations are not found. The results suggest that the spatial resolution of MEG is not sufficient for studying somatotopic representations in the human cerebellum.
2.Steady state response from the cerebellum
By delivering rhythmic 8 Hz and 16 Hz stimulation of the median nerve, steady state response from the cerebellum was elicited to 8 Hz stimulus.
3.Source estimation of the cerebellar response by multi-dipole estimation method
We were able to estimate cerebellar sources in only one third of the cases by multi-dipole estimation method. This is due to strong signals from SI which overshadow the cerebellar response and to low signal-to-noise ratio influenced by environmental magnetic noise.
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Report
(3 results)
Research Products
(32 results)
