| Project/Area Number |
16590853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
FURUTAMA Daisuke Osaka Medical College, Faculty of Medicine, Research Associate, 医学部, 助手 (70291987)
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| Co-Investigator(Kenkyū-buntansha) |
OHSAWA Nakaaki Aino Institute for Aging Research, President, 藍野短期大学・藍野加齢医学研究所, 所長 (90010090)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | slow fiber / fast fiber / gene expression / regeneration / 転写因子 / cis-element / 骨格筋 / 分化 |
|---|
| Research Abstract |
In this study we investigated the molecular mechanisms of muscle fiber type switching, especially slow to fast fiber switching. Using reporter plasmids for slow or fast fiber specific genes, we screened the cis-element for muscle fiber type specific gene expression. For example, the myoglobin gene promoter region must contain the slow fiber specific cis-element(s), whereas the myosin heavy chain 2A gene promoter could contain the fast fiber specific cis-element. We conducted these experiments several times and found the several cis-elements muscle fiber type specific gene expression.
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