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Investigation on the immune reactions against complex antigens including gangliosides in the neuroimmunological diseases

Research Project

Project/Area Number 16590854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKinki University

Principal Investigator

KUSUNOKI Susumu  Kinki University, School of Medicine, Professor, 医学部, 教授 (90195438)

Co-Investigator(Kenkyū-buntansha) MITSUI Yoshiyuki  Kinki University, School of Medicine, Associate Professor, 医学部, 助教授 (40268389)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsneuroimmunology / ganglioside / phospholipid / sialic acid / autoimmunity / Guillain-Barre syndrome / Miller Fisher syndrome / glycolipid / Fisher症候群
Research Abstract

Antiganglioside antibodies are frequently present in sera from patients with neuroimmunological diseases as Guillain Barre syndrome (GBS) and Miller Fisher syndrome (MFS). Each ganglioside coexists with phospholipids and other gangliosides in the plasma membrane. We investigated antibody reactivities against complex antigens composed of a ganglioside and a phospholipid or those composed of two species of gangliosides. Anti-GM1 IgG antibodies in GBS had stronger binding activities against a mixture of GM1 and such phospholipids as phosphatidic acid than against GM1 alone. However, such increase was not observed in anti-GQ1b IgG antibodies in MFS. This may be due to the difference in the amount of the negatively-charged sialic acid that each antigen has ; GM1 has one sialic acid whereas GQ1b has four sialic acids. Some GBS patients had the antibodies specific to the ganglioside complex, which is composed of two different gangliosides. Among them, the antibodies specific to GD1a-GD1b complex and/or GD1b-GT1b complex are associated with severe GBS requiring artificial ventilation. In addition, some MFS patients had the antibodies against ganglioside complexes that include GQ1b. For elucidating the pathogenetic roles of the antiganglioside antibodies in neuroimmunological diseases, we should pay attention on the antibody activities against those complex antigens. Investigating antibodies against the complex antigens also may be useful for diagnosis of neuroimmunological diseases as GBS and MFS.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (22 results)

All 2005 2004 Other

All Journal Article (22 results)

  • [Journal Article] Effects of phospholipids on antiganglioside antibody reactivity in GBS.2005

    • Author(s)
      Hirakawa M, Morita D, Tsuji S, Kusunoki S.
    • Journal Title

      J Neuroimmunol 159

      Pages: 129-132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Harmful effects of anti-GalNAc-GD1a antibodies and TNF-alpha on rat dorsal root ganglia.2005

    • Author(s)
      Kamakura K, Kaida K, Kusunoki S, Miyamoto N, Masaki T, Nakamura R, Motoyoshi K, Fukuda J.
    • Journal Title

      J Periph Nerv Sys 10

      Pages: 190-201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Autoantibodies in post-infectious acute cerebellar ataxia.2005

    • Author(s)
      Uchibori A, Sakuta M, Kusunoki S, Chiba A.
    • Journal Title

      Neurology 65

      Pages: 1114-1116

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Effects of phospholipids on antiganglioside antibody reactivity in GBS.2005

    • Author(s)
      Hirakawa M, Morita D, Tsuji S, Kusunoki S
    • Journal Title

      J Neuroimmunol 159

      Pages: 129-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Harmful effects of anti-GalNAc-GD1a antibodies and TNF-alpha on rat dorsal root ganglia.2005

    • Author(s)
      Kamakura K, Kaida K, Kusunoki S, Miyamoto N, Masaki T, Nakamura R, Motoyoshi K, Fukuda J
    • Journal Title

      Periph Nerv Sys 10

      Pages: 190-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Autoantibodies in post-infectious acute cerebellar ataxia.2005

    • Author(s)
      Uchibori A, Sakuta M, Kusunoki S, Chiba A
    • Journal Title

      Neurology 65

      Pages: 1114-1116

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Harmful effects of anti-GalNAc-GD1a antibodies and TNF-alpha on rat dorsal root ganglia.2005

    • Author(s)
      Kamakura K, Kaida K, Kusunoki S, Miyamoto N, Masaki T, Nakamura R, Motoyoshi K, Fukuda J Motoyoshi K, Fukuda J.
    • Journal Title

      Periph Nerv Sys 10

      Pages: 190-201

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Behcet disease presenting with neurological complications immediately after conversion from conventional cyclosporin A to microemulsion formulation.2005

    • Author(s)
      Mitsui Y, Mitsui M, Urakami R, Kihara M, Takahashi M, Kusunoki S
    • Journal Title

      Intern Med 44

      Pages: 149-152

    • NAID

      10014377660

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 抗ガングリオシド抗体研究の新たな展開2005

    • Author(s)
      楠 進
    • Journal Title

      末梢神経 16

      Pages: 50-54

    • NAID

      10019604182

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Harmful effects of anti-GalNAc-GD1a antibodies and TNF-alpha on rat dorsal root ganglia.2005

    • Author(s)
      Kamakura K, Kaida K, Kusunoki S, et al.
    • Journal Title

      J Periph Nerv Sys 10(in press)

      Pages: 190-201

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effects of phospholipids on antiganglioside antibody reactivity in GBS2005

    • Author(s)
      Hirakawa M, Morita D, Tsuji S, Kusunoki S
    • Journal Title

      J Neuroimmunol 159

      Pages: 129-132

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ganglioside complexes : as new target antigens in Guillain-Barre syndrome.2004

    • Author(s)
      Kaida K, Morita D, Kanzaki M, Kamakura K, Motoyoshi K, Hirakawa M, Kusunoki S.
    • Journal Title

      Ann Neurol 56

      Pages: 567-571

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barre syndrome.2004

    • Author(s)
      Kaida K, Kusunoki S, Kanzaki M, Kamakura K, Motoyoshi K, Kanazawa I.
    • Journal Title

      Neurology 62

      Pages: 821-824

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ganglioside complexes : as new target antigens in Guillain-Barre syndrome.2004

    • Author(s)
      Kaida K, Morita D, Kanzaki M, Kamakura K, Motoyoshi K, Hirakawa M, Kusunoki S
    • Journal Title

      Ann Neurol 56

      Pages: 567-571

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barre syndrome.2004

    • Author(s)
      Kaida K, Kusunoki S, Kanzaki M, Kamakura K, Motoyoshi K, Kanazawa I
    • Journal Title

      Neurology 62

      Pages: 821-824

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ganglioside complexes : as new target antigens in Guillain-Barre syndrome2004

    • Author(s)
      Kaida K, Morita D, Kanzaki M, Kamakura K, Motoyoshi K, Hirakawa M, Kusunoki S
    • Journal Title

      Ann Neurol 56

      Pages: 567-571

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling2004

    • Author(s)
      Hitoshi S, Seaberg RM, Koscik C, Alexson T, Kusunoki S, et al.
    • Journal Title

      Genes Dev 18

      Pages: 1806-1811

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barre syndrome2004

    • Author(s)
      Kaida K, Kusunoki S, Kanzaki M, et al.
    • Journal Title

      Neurology 62

      Pages: 821-824

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 肺炎マイコプラズマ菌体脂質成分によるウサギ感作:血中抗体の反応性の検討2004

    • Author(s)
      森田大児, 平川美菜子, 辻省次, 松田和洋, 楠 進
    • Journal Title

      臨床神経学 44

      Pages: 1093-1093

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Abnormal sudomotor axon reflex and antiganglioside antibodies.

    • Author(s)
      Kuzumoto Y, Shioyama M, Kihara M, Kusunoki S.
    • Journal Title

      Muscle Nerve (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Abnormal sudomotor axon reflex and antiganglioside antibodies.

    • Author(s)
      Kuzumoto Y, Shioyama M, Kihara M, Kusunoki S
    • Journal Title

      Muscle Nerve (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Abnormal sudomotor axon reflex and antiganglioside antibodies.

    • Author(s)
      Kuzumoto Y, Shioyama M, Kihara M, Kusunoki S
    • Journal Title

      Muscle Nerve, (in press)

    • Related Report
      2005 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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