| Project/Area Number |
16590873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Gifu University |
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Principal Investigator |
KOZAWA Osamu Gifu University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (90225417)
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| Co-Investigator(Kenkyū-buntansha) |
ISHISAKI Akira Hokkaido University, Graduate School of Dentistry, Associate Professor, 大学院・歯学研究科, 助教授 (20356439)
松野 浩之 岐阜大学, 大学院・医学研究科, 助教授 (40273148)
中島 恵一 岐阜大学, 大学院・医学研究科, 助手 (70362150)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | fibrinolytic system / osteoblasts / osteoclasts / bone metabolism / knock out mouse |
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| Research Abstract |
We investigated the role of fibrinolyitic system in bone metabolism. We obtained the results as follows :
1.Bone marrow cells derived from knockout mouse of urokinase-type plasminogen activator receptor have a more potency of calcification compared with those derived from wild type mouse.
2.In highly active fibrinolysis, bone density in femur is high while bone density in low active fibrinolysis is low.
3.Bone marrow cells derived from knockout mouse of plasminogen have a more potency of osteoclastic activity compared with those derived from wild type mouse.
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