• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of highly sensitive assay for TSH receptor antibody (TRAb) ; simultaneous measurements of TSAb, TSBAb, and TBII

Research Project

Project/Area Number 16590911
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

TAKASU Nobuyuki  University of the Ryukyus, Faculty of Medicine, Professor, 医学部, 教授 (20020927)

Co-Investigator(Kenkyū-buntansha) OHSHIRO Yuzuru  University of the Ryukyus, Faculty of Medicine, Instructor, 医学部, 助手 (40336376)
KOUKI Tsuyoshi  University of the Ryukyus, Faculty of Medicine, Instructor, 医学部, 助手 (80273415)
比嘉 盛丈  琉球大学, 医学部, 助手 (70347152)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsTSAb / TSBAb / TBII / TRAb / Graves' disease / Hashimoto's thyroiditis / hyperthyroidism / hypothyroidism / TSH受容体 / TSH受容体抗体 / 超高感度TSAb
Research Abstract

TSH receptor antibody (TRAb) causes Graves' disease. TSH-binding inhibitor immunoglobulin (TBII) and thyroid stimulating antibody (TSAb) have been measured as TSH receptor antibody (TRAb) to diagnose Graves' disease. TBII is measured as a receptor assay and TSAb as a stimulator assay. TSAb stimulates the thyroid gland and causes Graves' hyperthyroidism. TSAb reflects thyroid stimulating antibody (TSAb)-activity, but TBII does not necessarily do so. TBII may reflect the activity of TSH-stimulation blocking antibody (TSBAb). TSBAb causes hypothyroidism. TBII has been widely used to diagnose Graves' disease.
The aim of this study is to develop highly sTSAb (sensitive thyroid-stimulating antibody)-assay. We also intended to develop highly sensitive assay for TSH receptor antibody (TRAb), which would measure TSAb, TSBAb, and TBII, simultaneously.
We developed a highly sensitive TSAb (sTSAb) assay. We are now developing new assay to measure TSAb, TSBAb, and TBII, simultaneously.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (113 results)

All 2006 2005 2004 2003 Other

All Journal Article (100 results) Book (13 results)

  • [Journal Article] NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-kappaB signal pathway.2006

    • Author(s)
      Okudaira T, Takasu N
    • Journal Title

      Mol Cancer Ther 5 (3)

      Pages: 704-712

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma.2006

    • Author(s)
      Oshiro A, Takasu N
    • Journal Title

      Blood 107 (3)

      Pages: 1087-1091

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cardiac involvement of lung cancer presenting with acute myocardial infarction-like electrocardiographic changes.2006

    • Author(s)
      Kinjo Y, Takasu N
    • Journal Title

      Intern Med 45 (2)

      Pages: 113-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dys function in type 2 diabetic patients : a randomized cross-over study.2006

    • Author(s)
      Shimabukuro M, Takasu N
    • Journal Title

      J Clin Endocrinol Metab 91 (3)

      Pages: 837-842

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.2006

    • Author(s)
      Hasegawa H, Takasu N
    • Journal Title

      Blood 107 (2)

      Pages: 679-688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines.2006

    • Author(s)
      Tomita M, Takasu N
    • Journal Title

      Leuk Res 30 (3)

      Pages: 313-321

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Curcumin (diferuloylmethane) inhibts constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adut T-cell leukemia cells.2006

    • Author(s)
      Tomita M, Takasu N
    • Journal Title

      Int J Cancer 118 (3)

      Pages: 765-772

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transactivation of CCL20 gene by Epstein-Barr virus latent membrane protein 1.2006

    • Author(s)
      Okudaira T, Takasu N
    • Journal Title

      Br J Haematol 132 (3)

      Pages: 293-302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity.2006

    • Author(s)
      Higa M, Takasu N
    • Journal Title

      Diabetes Obes Metab 8 (2)

      Pages: 228-233

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of age on exophthalmos and TRAb in 123 Graves'patients and 560 normal control subjects; clinical usefulness of exophthalmos for the diagnosis of Graves' disease in the elderly in Japanese.2006

    • Author(s)
      Takasu N
    • Journal Title

      Austral J Ageing 132 (3)(In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rifampin-induced hypothyroidism.2006

    • Author(s)
      Takasu N
    • Journal Title

      J Endocrinol Invest 18 (3)(In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transactivation of the ICAM-1 gene by CD30 in Hodgkin's lymphoma.2006

    • Author(s)
      Uchihara JN, Matsuda T, Okudaira T, Ishikawa C, Masuda M, Horie R, Watanabe T, Ohta T, Takasu N, Mori N.
    • Journal Title

      Int J Cancer 118(5)

      Pages: 1098-1107

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients : a randomized crossover study.2006

    • Author(s)
      Shimabukuro M, Higa N, Chinen I, Yamakawa K, Takasu N.
    • Journal Title

      J Clin Endocrinol Metab 91(3)

      Pages: 837-842

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.2006

    • Author(s)
      Hasegawa H, Yamada Y, Komiyama K, Hayashi M, Ishibashi M, Yoshida T, Sakai T, Koyano T, Kam TS, Murata K, Sugahara K, Tsuruda K, Akamatsu N, Tsukasaki K, Masuda M, Takasu N, Kamihira S.
    • Journal Title

      Blood 107(2)

      Pages: 679-688

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines.2006

    • Author(s)
      Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Mori N.
    • Journal Title

      Leuk Res 30(3)

      Pages: 313-321

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells.2006

    • Author(s)
      Tomita M, Kawakami H, Uchihara JN, Okudaira T, Matsuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshioro K, Mori N.
    • Journal Title

      Int J Cancer 118(3)

      Pages: 765-772

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-kappaB signal pathway.2006

    • Author(s)
      Okudaira T, Tomita M, Uchihara JN, Matsuda T, Ishikawa C, Kawakami H, Masuda M, Tanaka Y, Ohshiro K, Takasu N, Mori N.
    • Journal Title

      Mol Cancer Ther 5(3)

      Pages: 704-712

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cardiac involvement of lung cancer presenting with acute myocardial infarction-like electrocardiographic changes.2006

    • Author(s)
      Kinjo Y, Nagasaki A, Teruya I, Nakachi K, Higa M, Komiya I, Takasu N.
    • Journal Title

      Intern Med 45(2)

      Pages: 113-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma.2006

    • Author(s)
      Oshiro A, Tagawa H, Ohshima K, Karube K, Uike N, Tashiro Y, Utsunomiya A, Masuda M, Takasu N, Nakamura S, Morishima Y, Seto M.
    • Journal Title

      Blood 107(3)

      Pages: 1087-1091

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Protein kinase B/Akt signalling is required for palmitate-induced beta-cell lipotoxicity.2006

    • Author(s)
      Higa M, Shimabukuro M, Shimajiri Y, Takasu N, Shinjyo T, Inaba T.
    • Journal Title

      Diabetes Obes Metab 8(2)

      Pages: 228-233

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transactivation of CCL20 gene by Epstein-Barr virus latent membrane protein 1.2006

    • Author(s)
      Okudaira T, Yamamoto K, Kawakami H, Uchihara JN, Tomita M, Masuda M, Matsuda T, Sairenji T, Iha H, Jeang KT, Matsuyama T, Takasu N, Mori N.
    • Journal Title

      Br J Haematol 132(3)

      Pages: 293-302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Influence of age on exophthalmos and TRAb in 123 Graves' patients and 560 normal control subjects ; clinical usefulness of exophthalmos for the diagnosis of Graves' disease in the elderly in Japanese.2006

    • Author(s)
      Takasu N, et al.
    • Journal Title

      Austral J Ageing (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rifampin-induced hypothyroidism.2006

    • Author(s)
      Takasu N, et al.
    • Journal Title

      J Endocrinol Invest (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transactivation of the ICAM-1 gene by CD30 in Hodgkin's Lymphoma.2006

    • Author(s)
      Uchihara JN, Takasu N
    • Journal Title

      Int J Cancer 118(5)

      Pages: 1098-1107

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.2006

    • Author(s)
      Hasegawa-H, Takasu N
    • Journal Title

      Blood 107(2)

      Pages: 679-688

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Low-dose metformin improves hyperglycaemia related to myotonic dystrophy.2005

    • Author(s)
      Kouki T, Takasu N
    • Journal Title

      Diabet Med 22 (3)

      Pages: 346-347

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rifampin-induced hypothyroidism in patients with Hashimoto's thyroiditis.2005

    • Author(s)
      Takasu N
    • Journal Title

      N Engl J Med 352 (5)

      Pages: 518-519

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Electrophysiologic Characteristics of Atrial Myocytes in Levo-thyroxine-Treated Rats.2005

    • Author(s)
      Sunagawa M, Takasu N
    • Journal Title

      Thyroid 15 (1)

      Pages: 3-11

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines.2005

    • Author(s)
      Matsuda T, Takasu N
    • Journal Title

      J Virol 79 (3)

      Pages: 1367-1378

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.2005

    • Author(s)
      Hasegawa H, Takasu N
    • Journal Title

      Br J Haematol 128 (2)

      Pages: 253-265

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1.2005

    • Author(s)
      Uchihara JN, Takasu N
    • Journal Title

      Int J Cancer 114 (5)

      Pages: 747-755

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute brain injury with hemiparesis due to hypoglycaemia.2005

    • Author(s)
      Ohshiro, Y, Takasu N
    • Journal Title

      Diabetic Medicine 22 (9)

      Pages: 1288-1289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats.2005

    • Author(s)
      Yamakawa M, Takasu N
    • Journal Title

      Thyroid 15 (7)

      Pages: 653-659

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Forty-year observation of 280 Japanese patients with congenital rubella syndrome.2005

    • Author(s)
      Takasu N
    • Journal Title

      Diabetes Care 22 (9)

      Pages: 2331-2332

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fucoidan extracted from cladosiphon okamuranus tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.2005

    • Author(s)
      Nutr Cancer
    • Journal Title

      Nutr Cancer 52 (2)

      Pages: 189-201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Low-dose metformin improves hyperglycaemia related to myotonic dystrophy.2005

    • Author(s)
      Kouki T, Takasu N, Nakachi A, Tamanaha T, Komiya I, Tawata M.
    • Journal Title

      Diabet Med 22(3)

      Pages: 346-347

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rifampin-induced hypothyroidism in patients with Hashimoto's thyroiditis.2005

    • Author(s)
      Takasu N, Takara M, Komiya I.
    • Journal Title

      N Engl J Med 352(5)

      Pages: 518-519

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Electrophysiologic Characteristics of Atrial Myocytes in Levo-thyroxine-Treated Rats.2005

    • Author(s)
      Sunagawa M, Yamakawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T.
    • Journal Title

      Thyroid 15(1)

      Pages: 3-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines.2005

    • Author(s)
      Matsuda T, Almasan A, Tomita M, Uchihara JN, Masuda M, Ohshiro K, Takasu N, Yagita H, Ohta T, Mori N.
    • Journal Title

      J Virol 79(3)

      Pages: 1367-1378

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sensitivity of adult T-cell leukaemia lymphoma cells to tumor necrosis factor-related apoptosis-inducing ligand.2005

    • Author(s)
      Hasegawa H, Yamada Y, Harasawa H, Tsuji T, Murata K, Sugahara K, Tsuruda K, Ikeda S, Imaizumi Y, Tomonaga M, Masuda M, Takasu N, Kamihira S.
    • Journal Title

      Br J Haematol 128(2)

      Pages: 253-265

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1.2005

    • Author(s)
      Uchihara JN, Krensky AM, Matsuda T, Kawakami H, Okudaira T, Masuda M, Ohta T, Takasu N, Mori N.
    • Journal Title

      Int J Cancer 114(5)

      Pages: 747-755

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute brain injury with hemiparesis due to hypoglycaemia-Reply.2005

    • Author(s)
      Ohshiro Y, Takasu N.
    • Journal Title

      Diabetic Medicine 22(9)

      Pages: 1288-1289

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats.2005

    • Author(s)
      Yamakawa M, Sunagawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T.
    • Journal Title

      Thyroid 15(7)

      Pages: 653-659

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Forty-year observation of 280 Japanese patients with congenital rubella syndrome.2005

    • Author(s)
      Takasu N, Ikema T, Komiya I, Mimura G.
    • Journal Title

      Diabetes Care 28(9)

      Pages: 2331-2332

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fucoidan extracted from cladosiphon okamuranus tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.2005

    • Author(s)
      Haneji K, Matsuda T, Tomita M, Kawakami H, Ohshiro K, Uchihara JN, Masuda M, Takasu N, Tanaka Y, Ohta T, Mori N.
    • Journal Title

      Nutr Cancer 52(2)

      Pages: 189-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Human T Cell Leukemia Virus Type I-Infected Patients with Hashimoto's Thyroiditis and Graves' Disease.2005

    • Author(s)
      Matsuda T, Tomita M, Uchihara JN, Okudaira T, Ohshiro K, Tomoyose T, Ikema T, Masuda M, Saito M, Osame M, Takasu N, Ohta T, Mori N.
    • Journal Title

      J Clin Endocrinol Metab 90(10)

      Pages: 5704-5710

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Severe hyperkalemia associated with "alternative" nutritional cancer therapy.2005

    • Author(s)
      Nagasaki A, Takamine W, Takasu N.
    • Journal Title

      Clin Nutr 24

      Pages: 864-865

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical usefulness of exophthalmos measurements for the diagnosis of Graves' disease in older Japanese people.2005

    • Author(s)
      Takasu N, Nakamatsu T, Nakachi K.
    • Journal Title

      J Am Geriatr Soc 53(12)

      Pages: 2231-2233

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Serial T1-weighted magnetic resonance imaging changes in a patient with central diabetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis.2005

    • Author(s)
      Ikema T, Takasu N.
    • Journal Title

      Eur J Endocrinol 153(6)

      Pages: 989-990

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute brain injury due to hypoglycemia.2005

    • Author(s)
      Ohshiro Y, Takasu N.
    • Journal Title

      Current Medical Literature ; Neurology 21(4)

      Pages: 65-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Review. [Nongenomic effects of thyroid hormaones]2005

    • Author(s)
      Takasu N.
    • Journal Title

      Nippon Rinsho.2005 63 Suppl10

      Pages: 142-152

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Rifampin-induced hypothyroidism in patients with Hashimoto's thyroiditis.2005

    • Author(s)
      Takasu N
    • Journal Title

      N Engl J Med 352(5)

      Pages: 518-519

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Forty-year observation of 280 Japanese patients with congenital rubella syndrome.2005

    • Author(s)
      Takasu N
    • Journal Title

      Diabetes Care 22(9)

      Pages: 2331-2332

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical usefulness of exophthalmos measurements for the diagnosis of Graves' disease in older Japanese people.2005

    • Author(s)
      Takasu N
    • Journal Title

      J Am Geriatr Soc 53(12)

      Pages: 2231-2233

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Low-dose metformin improves hyperglycaemia related to myotonic dystrophy.2005

    • Author(s)
      Kouki T, Takasu N
    • Journal Title

      Diabet Med 22(3)

      Pages: 346-347

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Electrophysiologic Characteristics of Atrial Myocytes in Levo-thyroxine-Treated Rats.2005

    • Author(s)
      Sunagawa M, Takasu N
    • Journal Title

      Thyrbid 15(1)

      Pages: 3-11

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis and constitutive expression of Apo2L/TRAIL in human T-cell leukemia virus type 1-infected T-cell lines.2005

    • Author(s)
      Matsuda T, Takasu N
    • Journal Title

      J Virol 79(3)

      Pages: 1367-1378

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.2005

    • Author(s)
      Hasegawa H, Takasu N
    • Journal Title

      Br J Haematol 128(2)

      Pages: 253-265

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transactivation of the CCL5/RANTES gene by Epstein-Barr virus latent membrane protein 1.2005

    • Author(s)
      Uchihara JN, Takasu N
    • Journal Title

      Int J Cancer 114(5)

      Pages: 747-755

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Acute brain injury with hemiparesis due to hypoglycaemia-Reply.2005

    • Author(s)
      Ohshiro, Y, Takasu N
    • Journal Title

      Diabetic Medicine 22(9)

      Pages: 1288-1289

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats.2005

    • Author(s)
      Yamakawa M, Takasu N
    • Journal Title

      Thyroid 15(7)

      Pages: 653-659

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Fucoidan extracted from cladosiphon okamuranus tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.2005

    • Author(s)
      Haneji K, Takasu N
    • Journal Title

      Nutr Cancer 52(2)

      Pages: 189-201

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Human T cell leukemia virus type I-infected patients with Hashimoto's thyroiditis and Graves' disease.2005

    • Author(s)
      Matsuda T, Takasu N
    • Journal Title

      J Clin Endocrinol Metab 90(10)

      Pages: 5704-5710

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Serial T1-weighted magnetic resonance imaging changes in a patient with central diabetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis.2005

    • Author(s)
      Ikema T, Takasu N
    • Journal Title

      Eur J Endocrinol 153(6)

      Pages: 989-990

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients: a randomized cross-over study.2005

    • Author(s)
      Shimabukuro M, Takasu N
    • Journal Title

      J Clin Endocrinol Metab 90(12)

      Pages: 6890-6899

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Severe hyperkalemia associated with "alternative" nutritional cancer therapy.2005

    • Author(s)
      Nagasaki A, Takasu N
    • Journal Title

      Clin Nutr 24(5)

      Pages: 864-865

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Acute brain injury due to hypoglycemia.2005

    • Author(s)
      Ohshiro Y, Takasu N
    • Journal Title

      Current Medical Literature ; Neurology 21(4)

      Pages: 65-68

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Nongenomic effects of thyroid hormones2005

    • Author(s)
      Takasu N
    • Journal Title

      Nippon Rinsho Suppl 10

      Pages: 142-152

    • NAID

      50001056103

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Electrophysiologic Characteristics of Atrial Myocytes in Levo-thyroxine-Treated Rats.2005

    • Author(s)
      Sunagawa M, Yamakawa M, Higa N, Takasu N, Kosugi T
    • Journal Title

      Thyroid 15(1)

      Pages: 3-11

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Resistance to Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis ・・・2005

    • Author(s)
      Matsuda T, Almasan A, Uchihara JN, M Takasu N, Mori N.
    • Journal Title

      J Virol 79(3)

      Pages: 1367-1378

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sensitive thyroid-stimulating antibody assay with high concentrations of polyethylene glycol for the diagnosis of Graves' disease.2004

    • Author(s)
      Takasu N
    • Journal Title

      Clin Exp Pharmacol Physiol. 31 (5-6)

      Pages: 314-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Very late central nervous system relapse in a pati ent with B cell ymphoblastic lymphoma.2004

    • Author(s)
      Nagasaki A, Takasu N
    • Journal Title

      Acta Haematol 112 (4)

      Pages: 212-216

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cilostazol, a phosphodiesterase inhibitor, reduces microalbuminuria in the insulin-resistant Otsuka Long-Evans Tokushima Fatty rat.2004

    • Author(s)
      Tohma T, Takasu N
    • Journal Title

      Metabolism 53 (11)

      Pages: 1405-1410

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese.2004

    • Author(s)
      Nawata H, Takasu N
    • Journal Title

      J Hum Genet 49 (11)

      Pages: 629-634

    • NAID

      10014115522

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A single dose of nateglinide improves post-challenge glucose metabolism and endothelial dysfunction in Type 2 diabetic patients.2004

    • Author(s)
      Shimabukuro M, Takasu N
    • Journal Title

      Diabet Med 21 (9)

      Pages: 983-986

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Primary malignant lymphoma of bone marrow.2004

    • Author(s)
      Nagasaki A, Takasu N
    • Journal Title

      Intern Med 43 (6)

      Pages: 524-525

    • NAID

      130000084677

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fluvastatin improves endothelial dysfunction in overweight postmenopausal women through small dense low-density lipoprotein reduction.2004

    • Author(s)
      Shimabukuro M, Takasu N
    • Journal Title

      Metabolism 53 (6)

      Pages: 733-739

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes.2004

    • Author(s)
      Hasegawa H, Takasu N
    • Journal Title

      Cell Immunol 231 (1-2)

      Pages: 1-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nitroglycerin spray rapidly improves pain in a patient with chronic painful diabetic neuropathy.2004

    • Author(s)
      Higa M, Takasu N
    • Journal Title

      Diabet Med 21 (9)

      Pages: 1053-1054

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute brain injury in hypglycaemia-induced hemiplegia.2004

    • Author(s)
      Shirayama H, Takasu N
    • Journal Title

      Diabet Med 21 (6)

      Pages: 623-624

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sensitive thyroid-stimulating antibody assay with high concentrations of polyethylene glycol for the diagnosis of Graves' disease.2004

    • Author(s)
      Takasu N, Kamijo K, Sato Y, Yoshimura H, Nagata A, Ochi Y.
    • Journal Title

      Clin Exp Pharmacol Physiol 31(5-6)

      Pages: 314-319

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Very late central nervous system relapse in a patient with B cell lymphoblastic lymphoma.2004

    • Author(s)
      Nagasaki A, Miyagi T, Nakazato T, Taira N, Ohshima K, Kikuchi M, Takasu N, Masauda M.
    • Journal Title

      Acta Haematol 112(4)

      Pages: 212-216

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cilostazol, a phosphodiesterase inhibitor, reduces microalbuminuria in the insulin-resistant Otsuka Long-Evans Tokushima Fatty rat.2004

    • Author(s)
      Tohma T, Shimabukuro M, Oshiro Y, Yamakawa M, Shimajiri Y, Takasu N.
    • Journal Title

      Metabolism 53(11)

      Pages: 1405-1410

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese.2004

    • Author(s)
      Nawata H, Shirasawa S, Nakashima N, Araki E, Hashiguchi J, Miyake S, Yamauchi T, Hamaguchi K, Yoshimatsu H, Takeda H, Fukushima H, Sasahara T, Yamaguchi K, Sonoda N, Sonoda T, Matsumoto M, Tanaka Y, Sugimoto H, Tsubouchi H, Inoguchi T, Yanase T, Wake N, Narazaki K, Eto T, Umeda F, Nakazaki M, Ono J, Asano T, Ito Y, Akazawa S, Hazegawa I, Takasu N, Shinohara M, Nishikawa T, Nagafuchi S, Okeda T, Eguchi K, Iwase M, Ishikawa M, Aoki M, Keicho N, Kato N, Yasuda K, Yamamoto K, Sasazuki T.
    • Journal Title

      J Hum Genet 49(11)

      Pages: 629-634

    • NAID

      10014115522

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A single dose of nateglinide improves post-challenge glucose metabolism and endothelial dysfunction in Type 2 diabetic patients.2004

    • Author(s)
      Shimabukuro M, Higa N, Takasu N, Tagawa T, Ueda S.
    • Journal Title

      Diabet Med 21(9)

      Pages: 983-986

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Primary malignant lymphoma of bone marrow.2004

    • Author(s)
      Nagasaki A, Hiroo H, Taira N, Takasu N, Masuda M.
    • Journal Title

      Intern Med 43(6)

      Pages: 524-525

    • NAID

      130000084677

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Fluvastatin improves endothelial dysfunction in overweight postmenopausal women through small dense low-density lipoprotein reduction.2004

    • Author(s)
      Shimabukuro M, Higa N, Asahi T, Oshiro Y, Takasu N.
    • Journal Title

      Metabolism 53(6)

      Pages: 733-739

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Restricted expression of tumor necrosis factor-related apoptosis-inducing ligand receptor 4 in human peripheral blood lymphocytes.2004

    • Author(s)
      Hasegawa H, Yamada Y, Harasawa H, Tsuji T, Murata K, Sugahara K, Tsuruda K, Masuda M, Takasu N, Kamihira S.
    • Journal Title

      Cell Immunol 231(1-2)

      Pages: 1-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Nitroglycerin spray rapidly improves pain in patient with chronic painful diabetic neuropathy.2004

    • Author(s)
      Higa M, Takasu N, Tamanaha T, Nakamura K, Shimabukuro M, Sasara T, Tawata M.
    • Journal Title

      Diabet Med 21(9)

      Pages: 1053-1054

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute brain injury in hypoglycaemia-induced hemiplegia.2004

    • Author(s)
      Shirayama H, Ohshiro Y, Kinjo Y, Taira S, Teruya I, Nakachi K, Tawata M, Takasu N.
    • Journal Title

      Diabet Med 21(6)

      Pages: 623-624

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Sensitive thyroid-stimulating antibody assay with high concent-rations of polyethylene glycol for the diagnosis of Graves' disea2004

    • Author(s)
      Takasu N, Kamijo K, Sato Y, Yoshimura H, Nagata A, Ochi Y
    • Journal Title

      Clin Exp Pharmacol Physiol 31(5-6)

      Pages: 314-319

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cilostazol, a phosphodiesterase inhibitor, reduces microalbuminuria in the insulin-resistant Otsuka Long-Evans Tokushima Fatty rat.2004

    • Author(s)
      Tohma T, Shimabukuro M, Oshiro Y, Yamakawa M, Takasu N
    • Journal Title

      Metabolism 53(11)

      Pages: 1405-1410

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese.2004

    • Author(s)
      Nawata H, Takasu N, et al.
    • Journal Title

      J Hum Genet 49(11)

      Pages: 629-634

    • NAID

      10014115522

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nongenomic effects of thyroid hormones.2003

    • Author(s)
      Takasu N
    • Journal Title

      Nippon Rinsho Suppl 10

    • NAID

      50001056103

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Human T cell leukemia virus type I-infected patients with Hashimoto's thyroiditis and Graves' disease.

    • Author(s)
      Matsuda T, Takasu N
    • Journal Title

      J Clin Endocrinol Metab 90 (10)

      Pages: 5704-5710

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Clinical usefulness of exophthalmos measurements for the diagnosis of Graves' disease in older Japanese people.

    • Author(s)
      Takasu N
    • Journal Title

      J Am Geriatr Soc 53 (12)

      Pages: 2231-2233

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Serial T1-Weighted magnetic resonance imaging changes in a patient with central diabetes insipidus, possibly due to lymphocytic infundibuloneurohypophysitis.

    • Author(s)
      Ikema T, Takasu N
    • Journal Title

      Eur J Endocrinol 153 (6)

      Pages: 989-990

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acute brain injury due to hypoglycemia.

    • Author(s)
      Ohshiro Y, Takasu N
    • Journal Title

      Current Medical Literature; Neurology 21 (4)

      Pages: 65-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Severe hyperkalemia associated with "alternative"nutritional cancer therapy.

    • Author(s)
      Nagasaki A, Takasu N
    • Journal Title

      Clin Nutr 24 (5)

      Pages: 864-865

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Transactivation of the ICAM-1 gene by CD30 in Hodgkin's Lymphoma.

    • Author(s)
      Uchihara JN, Takasu N
    • Journal Title

      Int J Cancer 118 (5)

      Pages: 1098-1107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 慢性甲状腺炎(橋本病).In : 今日の治療指針2005. (山口徹,北原光夫編)2005

    • Author(s)
      高須信行
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 内科医のための薬の禁忌100 第8章 内分泌内科.In : 内科医のための薬の禁忌100.(富野康日己編)2005

    • Author(s)
      高須信行
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 医療禁忌マニュアル、第3版2005

    • Author(s)
      高須信行
    • Publisher
      医歯薬出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] バセドウ病.In : わかりやすい免疫疾 (患宮坂信之編)2005

    • Author(s)
      高須信行
    • Publisher
      日本医師会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 甲状腺ホルモンのNongenomic effect. In : 臨床内分泌学3.2005

    • Author(s)
      高須信行
    • Publisher
      日本臨床社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 食べないのに体重が増加!?…甲状腺機能低下症.In : (花房利昭、伊藤充編)内分泌疾患を探る2005

    • Author(s)
      高須信行
    • Publisher
      永井書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 内分泌内科.In : 医療禁忌診療科別マニュアル、(富野康日己総編集)2005

    • Author(s)
      高須信行
    • Publisher
      医歯薬出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 臨床内分泌学3「甲状腺ホルモンのnongenomic effect」(宮坂信之(編))2005

    • Author(s)
      高須信行
    • Publisher
      日本臨床社
    • Related Report
      2005 Annual Research Report
  • [Book] 単純性甲状腺種.In : 今日の治療指針2004,(山口徹,北原光夫編)2004

    • Author(s)
      高須信行
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 自己免疫性甲状腺疾患パセドウ病・橋本病 : 遺伝子多型とその応用.新しい診断と治療のABC「甲状腺疾患」,(森昌朋編)2004

    • Author(s)
      高須信行
    • Publisher
      最新医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Malmo Study, DPS, DPP, そして沖縄.糖尿病.In : 大規模臨床試験に学ぶ,(日本糖尿病協会編)2004

    • Author(s)
      高須信行
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] TSHとTRH. In : 今日の治療指針2005.(山口徹,北原光夫編)2004

    • Author(s)
      高須信行
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 新しい診断と治療のABC:甲状腺疾患(森昌朋編集)2004

    • Author(s)
      高須 信行
    • Publisher
      最新医学社、大阪
    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi