| Project/Area Number |
16590947
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kumamoto University |
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Principal Investigator |
OKADA Seiji Kumamoto University, Center for AIDS Research, Div.of Hematopoiesis, Professor, エイズ学研究センター, 教授 (50282455)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | BCL6 / AP-1 / Dendritic cells / Hematopoietic stem cells |
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| Research Abstract |
The proto-oncogene bcl-6 and c-fos are ubiquitously expressed in various tissues, and play important role for the differentiation, proliferation, apoptosis and oncogeneisis. In this study, I focused on the function of bcl-6 and c-fos for the hematologic cells, using transgenic and gene deficient mice.
1.Function of Bcl-6 on erythroid differentiation
Bcl-6 detected in the TER119highCD71high subset of erythroblasts in the spleen of neonatal mice may be required to retain the erythroblasts in the cell proliferation stage.
2.Function of Bcl-6 on dendritic cell differentiation
Bcl-6 deficient mice showed decreased umber of dendritic cells in spleen. Especially CD8+ subfraction of dendriti cells was completely deficient.
3.Function of c-fos on B cell differentiation
Using H2-c-fos transgenic mice, we showed that c-Fos positively regulated blimp-1 expression and terminal differentiation of activated B cells.
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