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Human herpesvirus 6 infection in adult patients after unrelated cord blood transplantation

Research Project

Project/Area Number 16590978
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokyo

Principal Investigator

TOMONARI Akira  The University of Tokyo, Institute of Medical Science, Clinical Associate, 医科学研究所, 助手 (30323645)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Satoshi  The University of Tokyo, Institute of Medical Science, Associate Professor, 医科学研究所, 助教授 (60226834)
TOJO Arinobu  The University of Tokyo, Institute of Medical Science, Professor, 医科学研究所, 教授 (00211681)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsCord blood transplantation / HHV-6 / GVHD / Leukemia / PCR / Encephalitis / Liver dysfunction / Rash / 生着不全 / サイトメガロウイルス
Research Abstract

Human herpesvirus 6 (HHV-6) is classified into variants A and B. HHV-6B cause significant complications after hematopoietic stem cell transplantation (SCT) including encephalitis, pneumonia, and bone marrow suppression. We studied HHV-6 infection in 23 adults after cord blood transplantation (CBT) using a real-time quantitative PCR method on serum samples. In 20 of 23 CBT patients (87%), HHV-6B DNA was found in at least one serum sample. HHV-6B DNAemia was found in 15 patients (65%) at week 2, 16 (70%) at week 3, and three (13%) at week 4. However, HHV-6B DNAemia was not found in all 20 patients examined at week 1. As a control, HHV-6B DNAemia in 21 BMT patients at weeks 2, 3, and 4 was examined. In four of 21 BMT patients (19%), HHV-6B DNAemia was found in a serum sample. The differences of the probability for HHV-6B DNAemia between CBT and BMT were significant at week 2, week 3, and week 2 or 3. In CBT patients, positive HHV-6B DNAemia at week 3 was significantly associated with early skin rash (88% vs 14%). In contrast, positive HHV-6B DNAemia at week 2 was not associated with skin rash.
By using the same methodology, we studied the incidence of HHV-6A infection in 50 adults after CBT. In one patient (2%), HHV-6A DNA was detected in serum samples on days 14, 21, and 28 after CBT. In the remaining 49 patients, HHV-6A DNA was not detected. Fever, skin rash, and liver dysfunction in our patient were considered to be associated with HHV-6A infection. This is the first report studying the incidence and the clinical features of HHV-6A infection in the early period after CBT.
In the present study, we examined the incidences of HHV-6 infection in adults after CBT by a real-time quantitative PCR method on serum samples. Because our study included only small patient number, prospective large-scale studies are needed to determine the role of HHV-6 infection in CBT patients.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (20 results)

All 2006 2005 2004 Other

All Journal Article (20 results)

  • [Journal Article] Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation2006

    • Author(s)
      Tomonari A, et al.
    • Journal Title

      Eur J Haematol (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Unrelated cord blood transplantation after myeloabl ative conditioning in patients with acute leukemia aged between 50 and 55 years.2006

    • Author(s)
      Konuma T, Tomonari A, et al.
    • Journal Title

      Bone Marrow Transplant 37

      Pages: 803-804

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning in patients with acute leukemia aged between 50 and 55 years.2006

    • Author(s)
      Konuma T, Ooi J, Takahashi S, Tomonari A, et al.
    • Journal Title

      Bone Marrow Transplant. 37

      Pages: 803-804

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning in patients with acute leukemia aged between 50 and 55 years.2006

    • Author(s)
      Konuma T, Tomonari A, et al.
    • Journal Title

      Bone Marrow Transplant (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Human herpesvirus 6 variant A infection with fever, skin rash, and liver dysfunction in a patient after unrelated cord blood transplantation.2005

    • Author(s)
      Tomonari A, et al.
    • Journal Title

      Bone Marrow Transplant 36

      Pages: 1109-1110

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning for adult patients with refractory anemia2005

    • Author(s)
      Ooi J, Tomonari A, et al.
    • Journal Title

      Int J Hematol 81

      Pages: 424-427

    • NAID

      10016453573

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation.2005

    • Author(s)
      Tomonari A, et al.
    • Journal Title

      Int J Hematol 81

      Pages: 352-355

    • NAID

      10015652251

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Unrelated cord blood transplantation for a human immunodeficiency virus-1-seropositive patient with acute lymphoblastic leukemia2005

    • Author(s)
      Tomonari A, et al.
    • Journal Title

      Bone Marrow Transplant 36

      Pages: 261-262

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 variant A infection with fever, skin rash, and liver dysfunction in a patient after unrelated cord blood transplantation.2005

    • Author(s)
      Tomonari, et al.
    • Journal Title

      Bone Marrow Transplant. 36

      Pages: 1109-1110

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning for adult patients with refractory anemia2005

    • Author(s)
      Ooi J, Iseki T, Takahashi S, Tomonari A et al.
    • Journal Title

      Int J Hematol. 81

      Pages: 424-427

    • NAID

      10016453573

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation.2005

    • Author(s)
      Tomonari, et al.
    • Journal Title

      Int J Hematol. 81

      Pages: 352-355

    • NAID

      10015652251

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Unrelated cord blood transplantation for a human immunodeficiency virus-1-seropositive patient with acute lymphoblastic leukemia2005

    • Author(s)
      Tomonari, et al.
    • Journal Title

      Bone Marrow Transplant. 36

      Pages: 261-262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Human herpesvirus 6 variant A infection with fever, skin rash, and live dysfunction in a patient after unrelated cord blood transplantation.2005

    • Author(s)
      Tomonari A, et al.
    • Journal Title

      Bone Marrow Transplant 36

      Pages: 1109-1110

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation2005

    • Author(s)
      Tomonari, A, et al.
    • Journal Title

      Int J Hematol (印刷中)

    • NAID

      10015652251

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Single institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematological malignancies.2004

    • Author(s)
      Takahashi S, Tomonari A, et al.
    • Journal Title

      Blood 104

      Pages: 3823-3820

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Unrelated cord blood transplantation with a reduced-intensity conditioning regimen following autologous transplantation for multiple myeloma.2004

    • Author(s)
      Yamada T, Tomonari A, et al.
    • Journal Title

      Int J Hematol 80

      Pages: 377-380

    • NAID

      10014023149

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Unrelated cord blood transplantation for adult patients with acute lymphoblastic leukemia.2004

    • Author(s)
      Ooi J, Tomonari A, et al.
    • Journal Title

      Leukemia 18

      Pages: 1905-1907

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Unrelated cord blood transplantation after myeloablative conditioning in patients over the age of 45 years.2004

    • Author(s)
      Ooi J, Tomonari A, et al.
    • Journal Title

      Br J Haematol 126

      Pages: 711-714

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Ganciclovir-related neutropenia after preemptive therapy for cytomegalovirus infection : comparison between cord blood and marrow transplantation.2004

    • Author(s)
      Tomonari, A, et al.
    • Journal Title

      Ann Hematol 83

      Pages: 573-577

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cord blood transplantation for acute myelogenous leukemia using a conditioning regimen consisting of granulocyte colony-stimulating factor-combined high-dose cytarabine, fludarabine, and total body irradiation

    • Author(s)
      Tomonari, et al.
    • Journal Title

      Eur J Haematol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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