| Project/Area Number |
16591010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IGARASHI Takashi The University of Tokyo, Faculty of Medicine, Professor, 医学部附属病院, 教授 (70151256)
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| Co-Investigator(Kenkyū-buntansha) |
SEKINE Takashi The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (50255402)
INATOMI Jun The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (00311960)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | angiotensin type II receptor blocker / Th1 action / renoprotective medicine / アンギオテンシンII受容体拮抗薬 / アンギオテンシンII受容体 / ARB / 腎機能 |
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| Research Abstract |
The change of Th1/Th2 balance is critical for the development of renal damage in various kind of chronic nephritis. Predominant Th1 activity is often seen in the patients and model mice with active stage of systemic lupus erythematosus (SLE). We gave angiotensin type II receptor blocker, olmesartan, 10mg/kg/day to MRL/lps (spontaneously manifesting lupus) mice (n = 10) aged 9 weeks for 19 weeks. Then, we checked Interferon-γ (INF-γ) and interleukin-4 (IL-4) levels in the supernatant of the cultured T cells from the spleen in mice MRL/lps mice with or without olmesartan administration. This revealed that there was no difference in INF-γ and IL-4 levels in the supernatants between the two groups. However, MRL/lps mice to which olmesartan was administered lived longer, than the MRL/lps mice to which olmesartan was not administered. Although olmesartan do not suppress the Th1 activity in MRL/lps mice, it may have a beneficial effect on various organs such as heart. This beneficial effect may elongate the life span of MRL/lps mice.
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