| Project/Area Number |
16591021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
KAMACHI Yoshiro Nagoya University, University Hospital, Assistant Professor, 医学部附属病院, 講師 (20343204)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Seiji Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (20313992)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | DNA Microarrays / Down syndrome / Transient Myeloproliferative disorder / Acute Megakaryoblastic leukemia |
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| Research Abstract |
Approximately 10% of newborns with Down syndrome develop transient myeloproliferative disorder (TMD), a disorder that is unique to infants with constitutional trisomy 21 or trisomy 21 mosaicism. TMD blasts disappear spontaneously within the first 3 months of life in the majority of cases. Despite the resolution of TMD, 20-30% of these newborns will go on to develop acute megakaryoblastic leukemia (AMKL) within the 3 years. In this study, samples from both TMD and AMKL patients were examined using DNA microarrays to study the pathogenic progression from TMD to AMKL. Because we were able to obtain only three high-quality mRNA from each patient group respectively, we could not find different gene expression pattern between two groups. In order to identify genes contributing to develop AMKL from TMD in DS patients using DNA microarrays, we have to increase available number of cases in future. Further studies are needed to identify genes contributing to develop AMKL from TMD in DS patients.
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