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Developmental mechanisms of higher cognitive functions: comprehensive analyses of genes involved in hemispheric laterality

Research Project

Project/Area Number 16591038
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKYUSHU UNIVERCITY

Principal Investigator

KIRA Ryutaro  Kyushu University, Graduate School of Medical Sciences, Research Associate, 大学院医学研究院, 助手 (70304805)

Co-Investigator(Kenkyū-buntansha) SAKAI Yasunari  Kyushu University Hospital, Research Associate, 大学病院, 助手 (10380396)
TORISU Hiroyuki  Kyushu University Hospital, Research Associate, 大学病院, 医員 (10398076)
SUGIYAMA Hiroyuki  Kyushu University, Graduate School of Sciences, Professor, 大学院理学研究院, 教授 (20124224)
TAKASHIMA Sachio  International University of Health and Welfare, Professor, 大学院, 教授 (70038743)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsBrain / Laterality / Polymorphism / Cognitive function / Memory / Neuroimaging / 遺伝子発現 / グルタミン酸受容体
Research Abstract

1. Laterality of gene expression in both cerebral or cerebellar hemispheres
We used a high density oligonucleotide microarray, and found several genes showing left-right hemispheric laterality of expression.
2. The relationship between retrieval success of episodic memory and task performance during the recognition of meaningless shapes: an event-related near-infrared spectroscopy study
To elucidate the neural basis of genuine "retrieval success" unaffected by semantic memory, we investigated the correlation between old/new effects and task performance of forty-two right-handed subjects during the recognition of meaningless shapes, by using event-related near-infrared spectroscopy. The old/new effects of the shapes were positively correlated with task performance in the bilateral inferior lateral parietal cortex (ILP), but predominantly in the left ILP. This finding indicated that the ILP was associated with genuine "retrieval success" and its lateralization was consistently left-sided irrespective of the type of stimulus.
3. Association studies between candidate genes and higher cognitive function (memory and verbal function)
We have been investigating a possible association between transcriptional factors and higher cognitive function (Wechsler Memory Scale-Revised and Verbal Fluency Score). Among those with nonsynonymous single nucleotide polymorphisms, we found that only general transcription factor II-I repeat domain containing 1 (GTF2IRD1) Va1652Met genotype exerted a significant influence on verbal fluency, with Met/Met subjects showing better scores compared to Val/Met and Val/Val subjects in 102 university students. The GTF2IRD1, located within 7q11.23, is expressed highly in fetal brain, and the mouse Gtf2ird 1 protein is especially abundant in the neural tube and craniofacial area in developing embryo. Therefore, GTF2IRD1 may affect development of human expressive language.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (17 results)

All 2006 2005 Other

All Journal Article (16 results) Book (1 results)

  • [Journal Article] Persistent diffusion abnormalities in the brainstem of three children with mitochondrial diseases.2006

    • Author(s)
      Sakai Y, Kira R, et al.
    • Journal Title

      AJNR Am Neuroradiol 27

      Pages: 332-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A Novel R275X Mutation of the SLC25A15 Gene in a Japanese Patient with the HHH Syndrome.2006

    • Author(s)
      Torisu T, Kira R, et al.
    • Journal Title

      Brain Dev 28

      Pages: 269-71

    • NAID

      10020330887

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Benign convulsion with mild gastroenteritis and benign familial infantile seizure.2006

    • Author(s)
      Sakai Y, Kira R, et al.
    • Journal Title

      Epilepsy Res 68

      Pages: 269-271

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Moyamoya syndrome in a splenectomized patient with β-thalassemia intermedia.2006

    • Author(s)
      Sanefuji M, Ohga S, KIra R, et al.
    • Journal Title

      J Child Neurol 21

      Pages: 75-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Persistent diffusion abnormalities in the brain stem of three children with mitochondrial diseases.2006

    • Author(s)
      Sakai Y, Kira R, Torisu H, Ihara K, Yoshiura T, Hara T
    • Journal Title

      AJNR Am J Neuroradiol 27

      Pages: 1924-1926

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A Novel R275X Mutation of the SLC25A15 Gene in a Japanese Patient with the HHH Syndrome.2006

    • Author(s)
      Torisu H, Kira R, Kanazawa N, Takemoto M, Sanefuji M, Sakai Y, Tsujino S, Hara T
    • Journal Title

      Brain Dev 28

      Pages: 332-335

    • NAID

      10020330887

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Benign convulsion with mild gastroenteritis and benign familial infantile seizure.2006

    • Author(s)
      Sakai Y, Kira R, Torisu H, Yasumoto S, Saito M, Kusuhara K, Hara T
    • Journal Title

      Epilepsy Res 68

      Pages: 269-271

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Moyamoya syndrome in a splenectomized patient with beta-thalassemia intermedia.2006

    • Author(s)
      Sanefuji M, Ohga S, Kira R, Yoshiura T, Torisu H, Hara T
    • Journal Title

      J Child Neurol 21

      Pages: 75-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Genetic susceptibility to simple febrile seizures : interleukin-1beta promoter polymorphisms are associated with sporadic cases.2005

    • Author(s)
      Kira R, et al.
    • Journal Title

      Neurosci Lett 384

      Pages: 239-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays.2005

    • Author(s)
      Takemoto M, Kira R, et al.
    • Journal Title

      J Neurovirol 11

      Pages: 299-305

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Genetic susceptibility to simple febrile seizures : interleukin-1beta promoter polymorphisms are associated with sporadic cases.2005

    • Author(s)
      Kira R, Torisu H, Takemoto M, Nomura A, Sakai Y, Sanefuji M, Sakamoto K, Matsumoto S, Gondo K, Hara T
    • Journal Title

      Neurosci Lett 384

      Pages: 239-244

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays.2005

    • Author(s)
      Takemoto M, Kira R, Kusuhara K, Torisu H, Sakai Y, Hara T
    • Journal Title

      J Neurovirol 11

      Pages: 299-305

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays2005

    • Author(s)
      Takemoto et al.
    • Journal Title

      Journal of NeuroVirology (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Persistent diffusion abnormalities in the brainstem of three children with mitochondrial diseases.

    • Author(s)
      Sakai Y, Kira R, et al.
    • Journal Title

      AJNR Am J Neuroradiol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Moyamoya syndrome in a splenectomized patient with β-thalassemia intermedia.

    • Author(s)
      Sanefuji M, Ohga S, Kira R, et al.
    • Journal Title

      J Child Neurol (in press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A Novel R275X Mutation of the SLC25A15 Gene in a Japanese Patient with the HHH Syndrome.

    • Author(s)
      Torisu T, Kira R, et al.
    • Journal Title

      Brain Dev (in press)

    • NAID

      10020330887

    • Related Report
      2005 Annual Research Report
  • [Book] 周期性四肢麻痺 今日の小児科治療指針 第14版2006

    • Author(s)
      吉良龍太郎(分担執筆)
    • Publisher
      医学書院 東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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