| Project/Area Number |
16591054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
SHIMIZU Toshiaki Juntendo University, School of Medicine, Professor (30260889)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Yasuhiro Juntendo University, School of Medicine, Assistant Professor (10420861)
TANAKA Kyoko Juntendo University, School of Medicine, Assistant Professor (70348928)
田中 恭子 順天堂大学, 医学部, 助手 (20407282)
米久保 明得 明治乳業(株), 研究本部・栄養科学研究所, 部長
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| Project Period (FY) |
2004 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,650,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | low birth weight infant / sphingomvelin / development / visual evoked potential / docosahexaenoic acid / breast milk / 極低出生体重児 / DHA / VEP検査 / Fagan発達検査 / Bayley発達検査 / 髄鞘形成 / グレリン / レプチン / IGF-I / Fagan発達評価 |
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| Research Abstract |
Objective ; This study was performed to examine the effects of sphingomyelin, on the mental, motor, and behavioral development of premature infants. Patients and Methods ; Twelve cases were assigned to the test group fed SM-fortified milk (SM 20% of all phospholipids) and 12 cases were assigned to the control group (SM 13%) .We analyzed the composition of plasma phospholipids and red cell membrane fatty acids. VEP and Fagan test , BSID-II and attention and memory test were performed. Results ; The mean levels of DHA and AA were not significantly different between the trial and control groups, the percentage of SM in the total phospholipids in the trial group was significantly higher than that in the control group at 4, 6 and 8 weeks The BRS of the BSID, the scores of the Fagan test, the latency of VEP and sustained attention test at 18 months were significantly higher in the trial group than in the controls. Conclusion ; This study was the first report that nutritional intervention with the administration of SM-fortified milk has positive association of neurobehavioral development of low birth weight infants. However, detailed studies of the association between the longer-term developmental prognosis and the effects of SM are required.
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