• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The investigation of the mechanisms of upregulated collagen production of cytokine-induced skin fibrosis model.

Research Project

Project/Area Number 16591093
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKANAZAWA UNIVERSITY

Principal Investigator

TAKEHARA Kazuhiko  Kanazawa University, School of Medicine, Professor, 医学系研究科, 教授 (50142253)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Manabu  Kanazawa University, School of Medicine, Associate Professor, 医学系研究科, 助教授 (90272591)
SHIRASAKI Fumiaki  Kanazawa University, School of Medicine, Lecture, 医学部附属病院, 講師 (10313644)
佐藤 伸一  長崎大学, 医歯薬学総合研究科, 教授 (20215792)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsTGF-β / CTGF / fibrosis / c-myc / collagen / b-FGF / 繊維化 / 中和抗体 / コラーゲン / 線維芽細胞
Research Abstract

We established cytokine induced skin fibrosis model. We injected TGF-β first which induces skin fibrosis and CTGF next which maintain skin fibrosis. In this study, we tried to clarify the detailed mechanism of this fibrosis model using in vitro study culture systems.
(1) TGF-β alone induced collagen m-RNA.
(2) CTGF alone had no effect.
(3) TGF-β plus CTGF induced collagen m-RNA more than TGF-β alone.
(4) TGF-β suppressed c-myc-mRNA in normal fibroblasts.
(5) In scleroderma fibroblasts c-myc-mRNA was enhanced by TGF-β plus CTGF stimulation.
Thus, abnormal response to scleroderma fibroblast may contribute to skin fibrosis in scleroderma.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (3 results)

All 2005 2004

All Journal Article (3 results)

  • [Journal Article] Connective Tissue Growth Factor Causes Persistent Proa2(I) Collagen Gene Expression Induced by Transforming Growth Factor-β in a Mouse Fibrosis Model2005

    • Author(s)
      Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, Inaoki M, Takigawa M, Takehara K
    • Journal Title

      Journal Cellular Physiology 203・2

      Pages: 447-456

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Connective Tissue Growth Factor Causes Persistent Proa2(I) Collagen Gene Expression I nduced by Transforming Growth Factor-βin a Mouse Fibrosis Model2005

    • Author(s)
      Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, Inaoki M, Takigawa M, Takehara K
    • Journal Title

      Journal Cellular Physiology 203(2)

      Pages: 447-456

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Connective tissue growth factor causes persistent proalpha 2(I) Collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model.2004

    • Author(s)
      Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, Inaoki M, Takigawa M, Takehara K
    • Journal Title

      Journal Cellular Physiology (in press)

    • Related Report
      2004 Annual Research Report

URL: 

Published: 2004-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi