The effect of endocrine disruptor for allergic disease using a mouse model exposed by tributyltin
| Project/Area Number |
16591109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Yokohama city university, School of Medicine |
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Principal Investigator |
KAZUO Takahashi Yokohama city university, School of Medicine, Associate professor, 医学部, 準教授 (40264618)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takuma Mie university, School of Medicine, Assistant, 医学部, 助手 (60224515)
千葉 由幸 横浜市立大学, 医学部附属病院, 助手 (20297493)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | tributyltin / Th1 / Th2 imbalance / endocrine disruptor |
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| Research Abstract |
Unfortunately chemical contamination in environment is considerably serious. Many changes of environmental agent are important in increase of allergic disease of these days, and we hypothesize it is caused by a large quantity of chemical contamination. We take up two chemicals, one is tributyltin (TBT), another one is formaldehyde (FA) which is causative agent of the sick house syndrome. TBT is one of environmental endocrine disrupter, and it let Th1/Th2 balance shift to Th2 recently, it is therefore indicated that TBT contributes to increase of allergic disease. It is not easy to analyse of environmental factor, but it is thought that it is necessary we pile up new knowledge, and to continue sounding an alarm bell as environmental issues.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Int Arch Allergy Immunol.2006
Author(s)
Iwamura C, Aihara M, Nakazawa M, Takahashi K, Yoshioka N, Matsukura S, Hirasawa T, Minami M, Ikezawa Z
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Journal Title
Int Arch Allergy Immunol. 141
Pages: 337-345
Description
「研究成果報告書概要(和文)」より
Related Report
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