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The effect of endocrine disruptor for allergic disease using a mouse model exposed by tributyltin

Research Project

Project/Area Number 16591109
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionYokohama city university, School of Medicine

Principal Investigator

KAZUO Takahashi  Yokohama city university, School of Medicine, Associate professor, 医学部, 準教授 (40264618)

Co-Investigator(Kenkyū-buntansha) KATO Takuma  Mie university, School of Medicine, Assistant, 医学部, 助手 (60224515)
千葉 由幸  横浜市立大学, 医学部附属病院, 助手 (20297493)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Keywordstributyltin / Th1 / Th2 imbalance / endocrine disruptor
Research Abstract

Unfortunately chemical contamination in environment is considerably serious. Many changes of environmental agent are important in increase of allergic disease of these days, and we hypothesize it is caused by a large quantity of chemical contamination. We take up two chemicals, one is tributyltin (TBT), another one is formaldehyde (FA) which is causative agent of the sick house syndrome. TBT is one of environmental endocrine disrupter, and it let Th1/Th2 balance shift to Th2 recently, it is therefore indicated that TBT contributes to increase of allergic disease. It is not easy to analyse of environmental factor, but it is thought that it is necessary we pile up new knowledge, and to continue sounding an alarm bell as environmental issues.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (14 results)

All 2007 2006 2005 2004

All Journal Article (14 results)

  • [Journal Article] Effects of tributyltin on the emotional behavior of C57BL/6 mice and the development of atopic dermatitis-like lesions in DS-Nh mice2007

    • Author(s)
      Kaoru Ohtaki, Michiko Aihara, Hinako Takahashi, Hiroyuki Fujita, Kazuo Takahashi, Toshiya Funabashi, Tsutomu Hirasawa, Zenro Ikezawa
    • Journal Title

      J Dermatol Sci. 46(in press)

    • NAID

      10024116982

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 環境化学物質とアトピー性皮膚炎2006

    • Author(s)
      高橋一夫
    • Journal Title

      皮膚の科学 5

      Pages: 24-28

    • NAID

      130004934484

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Endocrine disruptors promote Th2 polarization via depletion of intracellular glutathion levels in APC leading to the exacerbation of allergic diseases2006

    • Author(s)
      Takuma Kato, Saeko Tada- Oikawa, Kazuo Takahashi, Kanako Saito, LinangWang, Shosuke Kawanishi, Kagemasa Kuribayashi
    • Journal Title

      Eur. J. immunol 30・4(In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Int Arch Allergy Immunol.2006

    • Author(s)
      Iwamura C, Aihara M, Nakazawa M, Takahashi K, Yoshioka N, Matsukura S, Hirasawa T, Minami M, Ikezawa Z
    • Journal Title

      Int Arch Allergy Immunol. 141

      Pages: 337-345

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Endocrine disruptors promote Th2 polarization via depletion of intracellular glutathion levels in APC leading to the exacerbation of allergic diseases2006

    • Author(s)
      Takuma Kato, Saeko Tada-Oikawa, Kazuo Takahashi, Kanako Saito, LinangWang, Shosuke Kawanishi, Kagemasa Kuribayashi
    • Journal Title

      Eur.J.immunol 30

      Pages: 337-345

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Environmantal pollution and atopic dermatitis2006

    • Author(s)
      Kazuo Takahashi
    • Journal Title

      Skin Researchl 7 Suppl

      Pages: 24-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of tributyltin on the development of atopic dermatitis-like eruptions in DS-Nh mice.2006

    • Author(s)
      Iwamura C, Aihara M, Nakazawa M, Takahashi K, Yoshioka N, Matsukura S, Hirasawa T, Minami M, Ikezawa Z.
    • Journal Title

      Int Arch Allergy Immunol 141

      Pages: 337-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Endocrine disruptors promote Th2 polarization via depletion of intracellular glutathion levels in APC leading to the exacerbation of allergic diseases2006

    • Author(s)
      Takuma Kato, Saeko Tada-Oikawa, Kazuo Takahashi, Kanako Saito, Linang Wang, Shosuke Kawanishi, Kagemasa Kuribayashi
    • Journal Title

      Eur.J.immunol 30・4(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Th1/Th2バランスの観点から金属の免疫系への影響について2005

    • Author(s)
      高橋一夫
    • Journal Title

      アレルギーの臨床 25巻12号

      Pages: 996-997

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] アトピー性皮膚炎と金属2005

    • Author(s)
      高橋一夫
    • Journal Title

      皮膚アレルギーフロンティア 3巻3号

      Pages: 153-156

    • Related Report
      2005 Annual Research Report
  • [Journal Article] かぶれの抗原認識・免疫調節機構の最前線2004

    • Author(s)
      高橋一夫
    • Journal Title

      皮膚アレルギーフロンティア 2・4

      Pages: 7-12

    • Related Report
      2004 Annual Research Report
  • [Journal Article] アレルギー疾患の変容に環境ホルモンはどの程度関与しているだろうか2004

    • Author(s)
      高橋一夫
    • Journal Title

      アレルギー科 18・5

      Pages: 375-380

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 金属とTh1/Th2バランス2004

    • Author(s)
      高橋一夫
    • Journal Title

      臨床免疫 41・1

      Pages: 23-27

    • NAID

      110002403654

    • Related Report
      2004 Annual Research Report
  • [Journal Article] アトピー性皮膚炎と金属・金属アレルギー2004

    • Author(s)
      高橋一夫, 池澤善郎
    • Journal Title

      アレルギー科 17

      Pages: 549-554

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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