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Analysis of Interaction between NK cell and B cell

Research Project

Project/Area Number 16591116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKyorin University

Principal Investigator

KANO Yoko  Kyorin University, School of Medicine, Assistant professor, 医学部, 助教授 (20142416)

Co-Investigator(Kenkyū-buntansha) MIZUKAWA Yoshiko  Kyorin University, School of Medicine, assistant, 医学部, 助手 (50301479)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsDIHS / NK cell / B cell / anticonvulsant / CD122 / CD8^+T細胞
Research Abstract

1.CD69 expressions on CD4+Tcells, CD8+Tcells, NK cells and CD19+Bcells increased in peripheral blood taken from patients with drug-induced hypersensitivity syndrome (DIHS). In addition, CD122 expressions on NK cells decreased in the patients with DIHS as compared with those in control patients.
2.The characteristic of causative drugs was that those drugs have immunomodulatory potentials in common regardless each pharmacological action. In patients with DIHS, it is likely that interaction between NK cells and CD19+B cells is not able to act appropriately because of the defect of CD122 expression on NK cell. Therefore, CD19+ cells would not differentiate properly, which lead to decrease in serum immunoglobulin production in patients with DIHS.
3.Herpesvirus reactivation observed in patients with DIHS is analogous to that in patients after bone marrow transplantation. The mechanisms of the virus reactivation observed in patients with DIHS, therefore, may be similar to those of post bone marrow transplantation. To examine the mechanisms of the development of graft-versus-host disease will contribute to the clarification of the mechanisms of herpesvirus reactivation in patients with DIHS.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (25 results)

All 2006 2005 2004 Other

All Journal Article (24 results) Book (1 results)

  • [Journal Article] Drug-induced hypersensitivity syndrome(DIHS) : a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses2006

    • Author(s)
      Shiohara T, et al.
    • Journal Title

      Allergo Int 55・1

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Drug-induced hypersensitivity syndrome(DIHS) : a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses2006

    • Author(s)
      Shiohara T, Kano Y
    • Journal Title

      Allergo Int 55-1

      Pages: 1-8

    • NAID

      10020557219

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Drug-induced hypersensitivity syndrome(DIHS) : a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug Immune responses2006

    • Author(s)
      Shiohara T, et al.
    • Journal Title

      Allergology International 55・1

      Pages: 1-8

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Virus reactivation and intravenous immunoglobulin (IVIG) therapy of drug-induced hypersensitivity syndrome2005

    • Author(s)
      Kano Y, et al.
    • Journal Title

      Toxicology 209・2

      Pages: 166-167

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diagnosing drug eruptions in daily practice.2005

    • Author(s)
      Kano Y
    • Journal Title

      J Environ Dermatol 12・1

      Pages: 9-18

    • NAID

      10016568999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Are viral infections responsible for the development of drug-induced hypersensitivity syndrome as well as graft-versus-host disease?2005

    • Author(s)
      Shiohara T, et al.
    • Journal Title

      Dermatology 210・1

      Pages: 259-260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Virus reactivation and intravenous immunoglobulin (IVIG) therapy of drug-induced hypersensitivity syndrome2005

    • Author(s)
      Kano Y, Inaoka M, Sakuma K, Shiohara T
    • Journal Title

      Toxicology 209-2

      Pages: 165-167

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Diagnosing drug eruptions in daily practice.2005

    • Author(s)
      Kano Y
    • Journal Title

      J Environ Dermatol 12-1

      Pages: 9-8

    • NAID

      10016568999

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Are viral infections responsible for the development of drug-induced hypersensitivity syndrome as well as graft-versus-host disease?2005

    • Author(s)
      Shiohara T, Kano Y
    • Journal Title

      Dermatology 210-1

      Pages: 259-260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 薬疹とウイルス2005

    • Author(s)
      狩野葉子
    • Journal Title

      日本皮膚科学会雑誌 115・13

      Pages: 2043-2045

    • NAID

      10010138439

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 口唇診療マニュアル 固定薬疹2005

    • Author(s)
      狩野葉子
    • Journal Title

      Monthly Book Derma. 108・12

      Pages: 25-31

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ADH分泌異常症候群と脳炎を合併したdrug-induced hypersensitivity syndromeの1例2005

    • Author(s)
      佐久間 恵一, ほか
    • Journal Title

      臨床皮膚科 59・13

      Pages: 1302-1305

    • Related Report
      2005 Annual Research Report
  • [Journal Article] C型慢性肝炎のIFN療法中に出現した紅斑2005

    • Author(s)
      山崎 究, ほか
    • Journal Title

      臨床皮膚科 59・11

      Pages: 1059-1062

    • Related Report
      2005 Annual Research Report
  • [Journal Article] HHV-6の再活性化がみられたStevens-Johnson症候群2005

    • Author(s)
      狩野葉子
    • Journal Title

      Visual Dermatology 4・10

      Pages: 165-167

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 最近話題の薬疹2004

    • Author(s)
      狩野 葉子
    • Journal Title

      アレルギーの臨床 24(14)

      Pages: 32-36

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 分子標的薬と薬疹2004

    • Author(s)
      狩野 葉子
    • Journal Title

      医学のあゆみ 211(9)

      Pages: 894-895

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Sequential reactivation of herpesvirus in drug-induced hypersensitivity syndrome2004

    • Author(s)
      Kano Y, et al.
    • Journal Title

      Acta Derma Venereol 84(6)

      Pages: 484-485

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 新しい薬疹-その診断と治療-2004

    • Author(s)
      狩野 葉子
    • Journal Title

      MBデルマ 86(4)

      Pages: 34-40

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 発症機序に基づいたDIHSの治療2004

    • Author(s)
      狩野 葉子
    • Journal Title

      皮膚アレルギーフロンティア 2(1)

      Pages: 31-35

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia2004

    • Author(s)
      Kano Y, et al.
    • Journal Title

      Arch Dermatol 140(2)

      Pages: 183-188

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Several herpesvirus can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease

    • Author(s)
      Kano Y, et al.
    • Journal Title

      Br J Dermatol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hypogammaglobulinemia as an early sign of drug-induced hypersensitivity syndrome

    • Author(s)
      Kano Y, et al.
    • Journal Title

      J Am Acad Dermatol (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Several herpesvirus can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease

    • Author(s)
      Kano Y, Hirahara K, Sakuma K, Shiohara T
    • Journal Title

      Br J Dermatol (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Hypogammaglobulinemia as an early sign of drug-induced hypersensitivity syndrome

    • Author(s)
      Kano Y, Seishima M, Shiohara T
    • Journal Title

      J Am Acad Dermatol (In press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] 今日の治療指針2005

    • Author(s)
      狩野葉子(分担執筆)
    • Total Pages
      2
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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